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  1. 14981
    “…We will recruit 42 middle-aged and elderly patients with KOA aged ≥ 50 years and randomly divided into power cycling group, neuromuscular exercise group, and control group, and intervention will last for 12 weeks. …”
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    Effects of Internet of Things-based power cycling and neuromuscular training on pain and walking ability in elderly patients with KOA: protocol for a randomized controlled trial
  2. 14982
    “…BACKGROUND: Osteoarthritis (OA) is a chronic degenerative disease that is one of the main causes of disability in middle-aged and elderly people. Adipose stem cell (ASC)-derived exosomes (ASC-Exo) could repair cartilage damage and treat OA. …”
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    Exosomes derived from miR-338-3p-modified adipose stem cells inhibited inflammation injury of chondrocytes via targeting RUNX2 in osteoarthritis
  3. 14983
    “…CONCLUSIONS: Chronic productive cough is associated with a higher risk of death, while chronic dry cough has no impact on mortality risk of death in middle-aged and older adults. This highlights the importance of careful evaluation of patients with chronic cough.…”
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    Impact of productive and dry chronic cough on mortality in the Canadian Longitudinal Study on Aging (CLSA)
  4. 14984
    por Vali, Shaik Waseem, Lindahl, Paul A.
    Publicado 2022
    “…Spectra of young and middle-aged HFE kidneys were dominated by the central quadrupole doublet and were largely devoid of ferritin. …”
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    Low-temperature Mössbauer spectroscopy of organs from (57)Fe-enriched HFE((−/−)) hemochromatosis mice: an iron-dependent threshold for generating hemosiderin
  5. 14985
    “…Herein we demonstrated that the B-1 cell precursor population (B-1p) from bone marrow of middle-aged mice is higher than from young mice. Also, these aged cells are more resistant to irradiation and have downregulation of microRNA15a/16. …”
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    Age-related accumulation of B-1 cell progenitors in mice reflects changes in miR15a/16-1 expression and radioresistance capacity
  6. 14986
    “…That’s embarrassing to myself…” (Young men FGD). Our middle-aged participants also reported: “If I go to that clinic [mental health or counseling clinic], I am hoping and praying that I won’t bump into somebody that I know from the community” (Middle-aged women FGD). …”
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    2047 Mental illness public stigma, culture, and acculturation among Vietnamese Americans
  7. 14987
    “…The association between HTGW and hyperuricemia was more prominent among females (OR = 2.36; 95% CI: 1.77 to 3.15) than males (OR = 1.29; 95% CI: 0.82 to 2.04), with evidence of a multiplicative interaction (P = 0.006). CONCLUSIONS: Middle-aged and older females with the HTGW phenotype may at the highest risk of hyperuricemia. …”
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    Sex-related differences in the hypertriglyceridemic-waist phenotype in association with hyperuricemia: a longitudinal cohort study
  8. 14988
    “…The width dimensions of the genu and splenium increase till middle age and subsequently decreases in line with brain atrophy (p = 0.0000& p = 0.004). …”
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    MRI-based morphometric analysis of corpus callosum dimensions of adults in Southeast Nigeria
  9. 14989
    “…In the age analysis, mortality rate was higher in middle-aged and older adults than in other age groups. …”
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    Mortality trend analysis of ischemic heart disease in China between 2010 and 2019: a joinpoint analysis
  10. 14990
    “…This systematic review investigated efficacy of APM in the management of symptomatic meniscal damages in middle aged patients. Current available randomised controlled trials (RCTs) which compared APM performed in isolation or combined with physical therapy versus sham arthroscopy or isolated physical therapy were considered in the present systematic review. …”
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    No evidence in support of arthroscopic partial meniscectomy in adults with degenerative and nonobstructive meniscal symptoms: a level I evidence-based systematic review
  11. 14991
    “…BACKGROUND: Isolated rapid‐eye‐movement sleep behavior disorder (iRBD) is in most cases a prodrome of neurodegenerative synucleinopathies, affecting 1% to 2% of middle‐aged and older adults; however, accurate ambulatory diagnostic methods are not available. …”
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    Ambulatory Detection of Isolated Rapid‐Eye‐Movement Sleep Behavior Disorder Combining Actigraphy and Questionnaire
  12. 14992
    “…RESULTS: On average, patients were middle-aged (mean± SD: 52.5±13.2 years), obese (BMI, 35.4±7.9 kg/m²), and male (71.7%). …”
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    P109 Predicting major adverse cardiovascular events using symptom subtypes of severe obstructive sleep apnoea
  13. 14993
    “…Patients were subsequently categorized into those with PT, IT, and combined TMDs (CT) and also stratified by attendance period, sex, and age groups (adolescents/young adults [AY] and middle-aged/older adults [MO]) for statistical analyses using Chi-square/Mann-Whitney U tests and logistic regression analyses (α = 0.05). …”
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    The influence of the COVID-19 pandemic, sex, and age on temporomandibular disorders subtypes in East Asian patients: a retrospective observational study
  14. 14994
    “…This study aimed to examine the separate and combined association of SUA and fasting plasma glucose (FPG) or diabetes mellitus (DM) with cognition in a sample of Chinese middle-aged and elderly population. METHODS: A total of 6,509 participants aged 45 years or older who participated in the China Health and Retirement Longitudinal Study (CHARLS, 2011) were included. …”
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    Association of serum uric acid and fasting plasma glucose with cognitive function: a cross-sectional study
  15. 14995
    “…Replication study results highlighted: persistent debilitation from physical ill health and/or medication side effects; demographic factors (ie, middle-aged, single or never married); and personal coping strategies (ie, smoking) as risk factors for suicidal ideation. …”
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    Longitudinal investigation of the presence of different trajectories and associated health and socio-economic determinants, for participants who report suicidal ideation within a community-based public health survey
  16. 14996
    “…For instance, 37% of symptomatic infections occurred in Île-de-France, but 45% of sick leaves. Middle-aged workers bore disproportionately high sick leave burden, owing predominantly to greater incidence of contact sick leaves. …”
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    Sick leave due to COVID-19 during the first pandemic wave in France, 2020
  17. 14997
    por Si, Zhihua, Li, Lin, Han, Jingzhe
    Publicado 2023
    “…CONCLUSION: Patients with HSE who had normal CSF were typically middle-aged women with normal immune function. They showed typical HSE clinical features, such as fever, headache and epilepsy, that did not differ from those of other HSE patients. …”
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    Analysis of Metagenomic Next-Generation Sequencing (mNGS) in the Diagnosis of Herpes Simplex Virus (HSV) Encephalitis with Normal Cerebrospinal Fluid (CSF)
  18. 14998
    “…CONCLUSIONS: The association of eGFR with mortality risk appeared to be varied by its measures and by diabetes status among middle‐aged and older Chinese, which needs to be considered in clinical practice.…”
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    Glomerular filtration rate estimated by differing measures and risk of all‐cause mortality among Chinese individuals without or with diabetes: A nationwide prospective study
  19. 14999
    “…In the multivariable logistic analysis, females (P < 0.001), youth (age <40 years) (P < 0.001), ≥ 2 comorbidities (P = 0.009), and severe infection in the acute phase (P = 0.006) were risk factors for developing long COVID. Middle age (40–60 years) was a risk factor for persistent long COVID one year after hospital discharge (P = 0.013). …”
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    A one-year follow-up study of systematic impact of long COVID symptoms among patients post SARS-CoV-2 omicron variants infection in Shanghai, China
  20. 15000
    “…Objective  Identify the prevalence and association of moderate to severe OSA with HT and ND pattern in hypertensive and non-hypertensive otherwise healthy middle-aged individuals in residing at high altitude (Bogotá:2640 mt) Methods  Adult individuals with diagnosis of moderate to severe OSA underwent 24 hour- ambulatory blood pressure monitoring (ABPM) between 2015 and 2017. …”
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    Is it Mandatory to do a 24 hour ABPM in all Patients with Moderate to Severe Obstructive Sleep Apnoea?
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