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  1. 15121
    “…We aimed to identify multimorbidity patterns and examined the associations of multimorbidity patterns and the number of chronic diseases with the risk of mortality among Chinese middle-aged and older adults. METHODS: We used data from the China Kadoorie Biobank and included 512,723 participants aged 30 to 79 years. …”
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    Multimorbidity patterns and association with mortality in 0.5 million Chinese adults
  2. 15122
    “…PURPOSE: The aim of this study is to measure the trajectory of healthy ageing among Chinese middle-aged and older population, and explore the disparity of the trajectory, as well as contributing factors, between urban and rural areas in China. …”
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    Urban-rural disparities in the healthy ageing trajectory in China: a population-based study
  3. 15123
    “…We analysed the role of SEP and the presence of chronic or rare conditions on 5-year survival (until 31 December 2016) using accelerated failure time models with Weibull distribution, reporting time ratios (TRs; 95% CI). RESULTS: In middle-aged, subjects with low SEP (either individual or contextual) had a prevalence of chronic conditions comparable with the prevalence in high SEP individuals 10 years older. …”
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    Socioeconomic inequalities in health status and survival: a cohort study in Rome
  4. 15124
    “…After exposure to ionizing radiation (0.1–2 Gy) at 7 weeks of age, the heterozygotes, but not WT littermates, displayed dose‐dependent mammary carcinogenesis with 0.8 Gy(−1) excess in hazard ratio during their middle age; the relative susceptibility of the heterozygotes was more prominent when rats were irradiated at 3 weeks of age. …”
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    Brca1 (L63X) (/+) rat is a novel model of human BRCA1 deficiency displaying susceptibility to radiation‐induced mammary cancer
  5. 15125
    “…DESIGN: Prospective cohort study. SETTING: Middle‐aged women in a cohort based on regular health screening examinations. …”
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    Metabolically healthy and unhealthy obesity and risk of vasomotor symptoms in premenopausal women: cross‐sectional and cohort studies
  6. 15126
    “…The patient population was late‐middle‐aged (59.0 ± 14.5 years), majority women (61.5%), and about half reported having a bachelor's degree. 58.1% of participants self‐identified as White, 25.7% as African American or Black, 6.8% as Spanish, Latino, or Hispanic, 3.0% as Asian or Pacific Islander, and 0.5% as Native American. …”
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    Cardiology clinic patient attitudes toward and potential personal utility of genetic testing: Findings from a unique multiracial clinical sample
  7. 15127
    “…Further analysis in the same participants showed that Cu/Zn-ratio might be a stronger risk indicator for pneumonia than serum C-reactive protein. In middle-aged and older Finnish men, increased serum Cu/Zn-ratio and Cu concentrations are each linearly associated with an increased risk of incident pneumonia. …”
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    Serum copper-to-zinc ratio and risk of incident pneumonia in caucasian men: a prospective cohort study
  8. 15128
    “…AIP was an independent risk factor for CAD in the middle-aged groups. However, the predictive value of AIP for detecting CAD was not better than that of the traditional blood lipid parameters such as LDL-C.…”
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    Correlation between atherogenic index of plasma and coronary artery disease in males of different ages: a retrospective study
  9. 15129
    “…Relative to the young horses (~ 3.9 years old), middle-aged horses (~ 14.8 years old) exhibited reduced leukocyte TERT gene expression, and increased POT1 and miR-223 abundance (all p < 0.05). …”
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    Exercise regulates shelterin genes and microRNAs implicated in ageing in Thoroughbred horses
  10. 15130
    “…However, little is known about ways to alleviate this. METHODS: Here, 37 middle-aged healthy participants were recruited, among which 32 were intravenously administrated with expanded NK cells and 5 with normal saline. …”
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    Characterization of age-related immune features after autologous NK cell infusion: Protocol for an open-label and randomized controlled trial
  11. 15131
    “…CONCLUSION: Common genetic variants are associated with eGFR decline in middle-aged adults with relatively low comorbidity burdens. …”
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    Polygenic association of glomerular filtration rate decline in world trade center responders
  12. 15132
    “…To clarify the best surgical procedure in middle-aged patients, we considered outcomes and major complications leading to surgical revision following an anatomically reduced fracture fixed with locking plate and reverse shoulder arthroplasty (RSA) in the treatment of type B/C fractures in patients between 50 and 75 years of age. …”
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    Anatomically reduced fixation should always be considered when treating B and C proximal epiphyseal humeral fractures
  13. 15133
    “…Accomplishing a urinary Na/K ratio of 2 would be desirable to achieve the DRIs dietary goals for both Na and K simultaneously in middle-aged Japanese men and women accustomed to Japanese dietary habits. …”
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    Investigation of the urinary sodium-to-potassium ratio target level based on the recommended dietary intake goals for the Japanese population: The INTERMAP Japan
  14. 15134
    “…This study has shown that among the black middle-aged adults we interviewed, the knowledge and salience of this message is low. …”
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    A qualitative exploration of English black adults’ views of strength and balance activities in mid-life
  15. 15135
    “…BACKGROUND: Comparison of 4 cannulated lag screws (3 inverted triangular cannulated screws + anti-rotating screws;4 CLS), dynamic hip screws + derotational screws (DHS + DS), and femoral neck fixation system (FNS) in the treatment of Biomechanical properties of middle-aged Pauwels type III femoral neck fractures. …”
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    Finite element comparative analysis of three different internal fixation methods in the treatment of Pauwels type III femoral neck fractures
  16. 15136
    “…CASE PRESENTATION: A middle-aged male presented with fever, productive cough, multifocal skin abscesses and multiple osteolytic lesions with pathological fractures. …”
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    Disseminated nontuberculous mycobacterial infection with cryptic immunodeficiency mimicking malignancy: a case report
  17. 15137
    “…This study examines the effect of IAP on the cognitive function of middle-aged and elderly rural women in India. METHODS: The study utilized the data from the Longitudinal Ageing Study in India (LASI 2017–18, Wave-1). …”
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    Exposure to indoor air pollution and the cognitive functioning of elderly rural women: a cross-sectional study using LASI data, India
  18. 15138
    “…Multivariate logistic regression analysis showed that older age (for the elderly group: OR = 5.096; for the middle-aged group: OR = 2.784), high BMI status (morbidly obese: OR = 3.465; obese: OR = 1.992), having hypertension (OR = 1.647), consuming fish more than twice per week (OR = 1.496), and abdominal obesity (OR = 1.464) were the five most important risk factors for hyperglycemia. …”
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    Hyperglycemia screening based on survey data: an international instrument based on WHO STEPs dataset
  19. 15139
    “…METHODS: We included 3495 individuals (aged 46.4 ± 5.4 years) from the Malmo Preventive Project (MPP), Sweden, born between 1921 and 1949, and 1401 young to middle-aged individuals (aged 28.6 ± 6.7 years) from the Malmo Offspring Study (MOS) with complete data on BW and gestational age. …”
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    Can birth weight predict offspring’s lung function in adult age? Evidence from two Swedish birth cohorts
  20. 15140
    “…PURPOSE: Knee osteoarthritis (OA) is the most common form of clinical arthritis in middle-aged and older individuals. Undenatured or native type II (TII) collagen derived from the chicken sternum has a good therapeutic effect on relieving severe pain of OA. …”
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    Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial
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