“…INTERPRETATION: In this population-based study, we found that acute appendicitis seems to be a warning sign for colon cancer (reverse causality) in both middle-aged and younger adults. The risk of presenting with cancer colon was higher during the first six months after acute appendicitis. …”
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“…PURPOSE: Despite evidence suggesting a decline in the physical activity of middle-aged adults, 40–64-year-olds participation in group exercise is actually increasing. …”
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“…The adjusted sub‐hazard ratios for middle‐aged with colorectal cancer, pancreatic cancer, hepatocellular cancer, gastric cancer, and esophageal cancer were 2.55 (95% CI: 2.15–3.03), 1.77 (95% CI: 1.06–2.97), 2.64 (95% CI: 1.60–4.36), 2.15 (95% CI: 1.32–3.51), and 2.28 (95% CI: 1.17–4.44), respectively. …”
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“…RESULTS: Three subgroups were identified: cluster 1, primarily middle-aged adults with high rates of smoking, alcohol use, short sleep duration, and low diet quality; cluster 2, mostly young non-white adults with low income, low health insurance coverage, and limited healthcare access; and cluster 3, mostly older males who were the least physically active, but with high insurance coverage and healthcare access. …”
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“…These causes were more common among middle-aged and older people and thus bore the most burden. …”
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“…METHODS AND RESULTS: Data were from 7024 UK Biobank middle-aged adults with established CAD at enrolment. …”
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“…BACKGROUND: Periodontitis is the most common type of periodontal condition, primarily affecting middle-aged people and resulting in tooth loss; when combined with diabetes, it becomes a debilitating condition. …”
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“…METHOD: Participants included 736 Dutch middle-aged to older adults from the SMART-MR cohort (mean age 58 ± 9.4 years, 18% women). …”
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“…The hypothesis that the polygenic variants associated with hypo-HDL-C interact with lifestyle factors was examined in 58,701 middle-aged Korean adults who participated in the Korean Genome and Epidemiology Study (KoGES). …”
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“…BACKGROUND AND OBJECTIVES: We aimed to investigate the white matter (WM) microstructural/cytostructural disintegrity patterns related to higher systolic blood pressure (SBP), and whether they mediate SBP effects on cognitive performance in middle-aged adults. METHODS: Using the UK Biobank study of community-dwelling volunteers aged 40–69 years, we included participants without a history of stroke, dementia, demyelinating disease or traumatic brain injury. …”
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“…CONCLUSION: Increased cardiovascular risk as evidenced by FRS was associated with poorer cognitive performance in all cognitive domains among dementia-free middle-aged and older rural Indians. It is imperative to design and implement appropriate interventions (pharmacological and lifestyle-based) for cardiovascular risk reduction and thereby, prevent or mitigate accelerated cognitive impairment in ageing individuals.…”
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“…BACKGROUND: Nature therapy can significantly benefit the physiology and psychology of middle-aged and older people, but previous studies have focused on forest environments. …”
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“…RESULTS: There was a high–early rate of pneumonia within 30 days post-fracture for young, middle-aged, and elderly adults with intellectual disabilities (n = 6,183); this rate was 2.2- to 6.1-fold higher than the rate among the w/oFx (n = 12,366) and GP+Fx (n = 363,995) cohorts (all P < 0.05). …”
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“…KEY CLINICAL MESSAGE: Middle‐aged male athletes, with or without underlying coronary artery disease, exhibiting exercise induced blood pressure (BP) variability and diabetes can have an increased risk of developing atrial fibrillation (AF). …”
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“…Age was correlated first with a decrease from dogs <1 year of age to middle-age (⩾3 to <8 years) dogs and later with an increase of ADC values in dogs ⩾8 years. …”
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“…Herein, we present a unique case of atraumatic OXINIUM™ wear in a middle-aged female after uneventful primary total knee arthroplasty (TKA), highlighting atypical clinical features and addressing the surgical management of this unexpected implant failure. …”
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“…METHODS: We studied 27,141 middle-aged adults from the Malmö Diet and Cancer study (MDCS) with a mean follow up of 21 years. …”
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“…METHOD: Between 1974 and 1992, a total of 22 044 middle-aged individuals participated in a health screening, which included a spirometry as well as recording of respiratory symptoms and smoking habits. …”
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“…We hypothesized that right common carotid artery (RCCA) diameter would be independently associated with cardiac disease and improve risk discrimination. METHODS: In a middle-aged, biracial population (baseline n = 11225), we examined associations between 1 standard deviation increments of baseline RCCA diameter with prevalent myocardial infarction (MI) and incident cardiac events (MI or cardiac death) using logistic regression and Cox proportional hazards models, respectively. …”
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“…BACKGROUND: Obstructive sleep apnea (OSA) is a prevalent and serious medical condition characterized by repeated complete or partial obstructions of the upper airway during sleep and is prevalent in 2% to 4% of working middle-aged adults. Nasal continuous positive airway pressure (CPAP) is the gold-standard treatment for OSA. …”
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