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  1. 15301
    “…Patients were divided into 3 groups by age, young group (<45 years), middle-aged group (45–65 years), and elderly group (>65 years). …”
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    Double-balloon enteroscopy in small bowel diseases: Eight years single-center experience in China
  2. 15302
    “…Regarding T-bet and Eomes transcription factors, CMV seropositivity was associated with a decrease of T-bet(hi) in CD56(dim)CD57(+) NK cells from young individuals, whereas Eomes expression was increased with CMV seropositivity in both CD56(bright) and CD56(dim)CD57(+/−) (from middle age and young individuals, respectively) and was decreased with aging in all NK subsets from the three group of age. …”
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    Effect of CMV and Aging on the Differential Expression of CD300a, CD161, T-bet, and Eomes on NK Cell Subsets
  3. 15303
    “…During the oral glucose tolerance test (OGTT), 30 min insulin and C-peptide levels, 120 min insulin levels and ratio of the increases of insulin and blood glucose levels after 30 min of sugar loading (∆Ins30/∆Glu30) were significantly lower in elderly patients than in middle-aged patients (P<0.05). In addition, the glucagon elevation at 30 min was higher and the glucagon-like peptide-1 (GLP-1) at 30 min was lower in the elderly patients (P<0.05). …”
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    Effects of sitagliptin as initial therapy in newly diagnosed elderly type 2 diabetics: A randomized controlled study
  4. 15304
    “…Participants (N=2344) were white (57%), middle‐aged (47.2±19.0 years), and overweight (26.8±3.4 kg/m(2)) adults with prehypertension (126.7±10.3/76.8±8.7 mm Hg); 15% were on antihypertensive medication. …”
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    Dynamic Resistance Training as Stand‐Alone Antihypertensive Lifestyle Therapy: A Meta‐Analysis
  5. 15305
    “…CONCLUSIONS: Higher FT4, but not TSH and FT3, was associated with increased risk of incident CKD and rapid eGFR decline in middle-aged and elderly Chinese.…”
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    Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation
  6. 15306
    “…Materials and Methods: The sample consisted of a total of 300 Cypriots who visited Kofinou Health Centre in the period between July and September 2015. For the middle-aged citizens, the Greek version of the Hospital Anxiety Depression Scale (HADS) was applied to 150 persons [1], while for the visiting senior citizens (aged over 65 years), the Greek version of the Geriatric Depression Scale (GDS) was used [2]. …”
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    Mental Health in Cypriot Citizens of the Rural Health Centre Kofinou
  7. 15307
    “…A total of eighty computer users were recruited from two age cohorts (young adults: 18–30 yrs, middle-aged adults: 40–55 yrs). Contrast sensitivity under standard and glare conditions, and colour discrimination were measured using standard clinical tests. …”
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    Blue-Light Filtering Spectacle Lenses: Optical and Clinical Performances
  8. 15308
    “…We report the first case of myopericarditis following Campylobacter coli enterocolitis, with illness occurring in an immunocompetent middle-aged female. CASE PRESENTATION: A 51-yo female was admitted to a cardiology unit with a 3-days history of chest pain. …”
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    First case report of myopericarditis linked to Campylobacter coli enterocolitis
  9. 15309
    “…BACKGROUND: UK Biobank is a large prospective cohort study in the UK established by the Medical Research Council (MRC) and the Wellcome Trust to enable approved researchers to investigate the role of genetic factors, environmental exposures and lifestyle in the causes of major diseases of late and middle age. A wide range of phenotypic data has been collected at recruitment and has recently been enhanced by the UK Biobank Genotyping Project. …”
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    Comparison of DNA quantification methodology used in the DNA extraction protocol for the UK Biobank cohort
  10. 15310
    “…Nevertheless, it sheds light on the possibility that upward mobility may be beneficial to reduce stress-related health problems in mid-life over and above the exposure to prior and current class, while downward mobility can be of less importance for middle-age health complaints.…”
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    Intragenerational social mobility and functional somatic symptoms in a northern Swedish context: analyses of diagonal reference models
  11. 15311
    “…CONCLUSIONS: Married adult epileptic patients have better quality of life than that of unmarried adult patients in young and middle-aged age groups. Unmarried adult patients with epilepsy are more anxious and depressed than married adult patients.…”
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    Influence of Marital Status on the Quality of Life of Chinese Adult Patients with Epilepsy
  12. 15312
    “…CONCLUSIONS: In this population-based study of middle-aged to older African-American adults, we report an association between accelerated epigenetic aging and increased WMH burden, independent of known risk factors, including chronologic age. …”
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    Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study
  13. 15313
    “…This single center case series is the first to show successful endoscopic OTSC(®) closure of long lasting GCF in five consecutive middle-aged patients with significant comorbidities. …”
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    Over-the-scope-clip closure of long lasting gastrocutaneous fistula after percutaneous endoscopic gastrostomy tube removal in immunocompromised patients: A single center case series
  14. 15314
    “…PURPOSE: A degenerative meniscus lesion is a slowly developing process typically involving a horizontal cleavage in a middle-aged or older person. When the knee is symptomatic, arthroscopic partial meniscectomy has been practised for a long time with many case series reporting improved patient outcomes. …”
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    Surgical management of degenerative meniscus lesions: the 2016 ESSKA meniscus consensus
  15. 15315
    “…A substantial part of adult outpatients with eczema or dermatitis is adult AD. Middle age, more body location involvement, more suspected bacterial infection, and severe itching are the main clinical feathers of adult AD. …”
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    Prevalence and clinical features of adult atopic dermatitis in tertiary hospitals of China
  16. 15316
    “…BACKGROUND: Despite recommendations, many middle-age adults neglect to check their blood cholesterol levels. …”
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    Application of short message service to control blood cholesterol: a field trial
  17. 15317
    “…CONCLUSIONS: In this sample of middle-aged adults, drawn from the general population, physical activity was inversely associated with BMI and body fat percentage. …”
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    Association between physical activity and body fat percentage, with adjustment for BMI: a large cross-sectional analysis of UK Biobank
  18. 15318
    “…RESULTS: Regarding the clinical profiles at intake, patients were middle-aged (M = 38.56, SD = 10.91), with a higher proportion of women (62.22%). …”
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    Emotional crisis in a naturalistic context: characterizing outpatient profiles and treatment effectiveness
  19. 15319
    “…BACKGROUND: Cervical dystonia (CD) involves painful involuntary contraction of the neck and shoulder muscles and abnormal posture in middle-aged adults. Botulinum neurotoxin type A (BoNT-A) is effective in treating CD but little is known about its associated cost-effectiveness. …”
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    Cost-effectiveness analysis of abobotulinumtoxinA for the treatment of cervical dystonia in the United Kingdom
  20. 15320
    “…Personal or societal based relevant stressors included male child preference, having an unmarried middle aged daughter, lack of empowerment and respect reported by females. …”
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    Adaptation of the Recent Life Changes Questionnaire (RLCQ) to measure stressful life events in adults residing in an urban megapolis in Pakistan
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