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  1. 15541
    “…Migraine is a major cause of disability worldwide, particularly in young adults and middle-aged women. Xiongshao Zhitong Recipe (XZR) is a traditional Chinese medicine prescription used for treating migraine, but its bioactive components and therapeutic mechanisms remain unclear. …”
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    Xiongshao Zhitong Recipe Attenuates Nitroglycerin-Induced Migraine-Like Behaviors via the Inhibition of Inflammation Mediated by Nitric Oxide Synthase
  2. 15542
    “…The assay was used to measure the mCRP level in 80 middle-aged individuals with initially moderate cardiovascular SCORE risk. …”
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    The monomeric C-reactive protein level is associated with the increase in carotid plaque number in patients with subclinical carotid atherosclerosis
  3. 15543
    “…Pouch use is largely concentrated among younger and middle-aged men who use other nicotine products and have a history of smoking. …”
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    Tobacco-free Nicotine Pouch Use in Great Britain: A Representative Population Survey 2020–2021
  4. 15544
    “…OBJECTIVE: Extracranial vertebral artery dissection (EVAD) is one of the main causes of stroke in young and middle-aged patients. However, the diagnosis is challenging. …”
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    Predictors of ischemic events in patients with unilateral extracranial vertebral artery dissection: A single-center exploratory study
  5. 15545
    por Kucukciloglu, Yasemin, Aydın, Deniz
    Publicado 2022
    “…We aimed to assess the relationship between radiological measurements of subcoracoid impingement and subscapularis tendon lesions in young and middle-aged adults. METHODS: This study was designed as a retrospective cohort study. …”
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    Relationship between Radiological Measurement of Subcoracoid Impingement and Subscapularis Tendon Lesions
  6. 15546
    “…CONCLUSIONS: The pro-fibrotic biomarker MMP7, but not MMP2 or TIMP1, is associated with increased risk of accelerated GFR decline and incident CKD in middle-aged persons from the general population.…”
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    Serum matrix metalloproteinase 7 and accelerated glomerular filtration rate decline in a general non-diabetic population
  7. 15547
    “…CONCLUSIONS: These results indicate that Pg OMVs prompt memory dysfunction, neuroinflammation, and tau phosphorylation and trigger NLRP3 inflammasome in the brain of middle-aged mice. We propose that Pg OMVs play an important role in activating neuroinflammation in the AD-like pathology triggered by Porphyromonas gingivalis, and NLRP3 inflammasome activation is a possible mechanism.…”
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    Outer membrane vesicles of Porphyromonas gingivalis trigger NLRP3 inflammasome and induce neuroinflammation, tau phosphorylation, and memory dysfunction in mice
  8. 15548
    “…This study is aimed at investigating the effects of hypertension, waist-to-height ratio (WHtR), and their dynamic transitions on type 2 diabetes mellitus (T2DM) onset among middle-aged and elderly people in China. METHODS: We analyzed 9843 participants free of T2DM (average age, 59.04 ± 9.26 years) at baseline from the China Health and Retirement Longitudinal Study. …”
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    Effect of Hypertension, Waist-to-Height Ratio, and Their Transitions on the Risk of Type 2 Diabetes Mellitus: Analysis from the China Health and Retirement Longitudinal Study
  9. 15549
    “…We noted a 7.3-fold (95% CI 4.8 to 11.0; p < 0.001) gradient in risk across deciles of the score among 288,289 middle-aged participants of the UK Biobank study. In cross-sectional analyses stratified by age, minimal differences in risk of Alzheimer’s disease and performance on a digit recall test were present according to polygenic score decile at age 50 years, but significant gradients emerged by age 65. …”
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    Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease
  10. 15550
    “…CONCLUSIONS: The typical presentation of a cerebral aneurysm is unruptured with a pre-dominance in middle-aged females. Our findings are congruent with the literature regarding the location of the aneurysm originating in the anterior circulation. …”
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    Single Center Retrospective Analysis of Cerebral Aneurysms from a Patient Sample Data Collection at a Comprehensive Stroke Center
  11. 15551
    “…In this study, among middle-aged and older Chinese, we investigated (i) the association of baseline FGCRS with subsequent cognitive decline and (ii) the association of FGCRS change with concomitant cognitive decline. …”
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    Association of baseline level of cardiovascular risk burden and its temporal changes with cognitive decline
  12. 15552
    “…CASE SUMMARY: One 33-year-old middle-aged man presented with a thymus mass without any clinical symptoms when he underwent regular physical examination. …”
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    Postoperative radiotherapy for thymus salivary gland carcinoma: A case report
  13. 15553
    “…The majority of the patients were male (81.9%), married (98.2%), rural residents (79.2), middle-aged (40–60 years of age) (55.8%), low-income holders (89.4%), and overweight (56.9%). …”
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    Factors Responsible for Prehospital Delay in Patients with Acute Coronary Syndrome in Bangladesh
  14. 15554
    “…RESULTS: The overall prevalence of LBD/osteoporosis in middle‐aged or elderly T2DM patients was 35.7% (n = 434), and the overall incidence of MOFs was 10.5% (n = 116). …”
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    Association of skin autofluorescence with low bone density/osteoporosis and osteoporotic fractures in type 2 diabetes mellitus
  15. 15555
    “…OBJECTIVE: The Cohort Hip and Cohort Knee (CHECK) is a cohort of middle‐aged individuals with hip or knee pain. Radiographs were assigned Kellgren/Lawrence (K/L) scores under different conditions at each follow‐up visit for 10 years. …”
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    Kellgren/Lawrence Grading in Cohort Studies: Methodological Update and Implications Illustrated Using Data From a Dutch Hip and Knee Cohort
  16. 15556
    “…As a result, we propose that the exercise ECG be utilized on a regular basis in middle-aged asymptomatic individuals to measure the frequency of PVCs and stratify the risk of mortality. …”
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    Revisiting exercise-induced premature ventricular complexes as a prognostic factor for mortality in asymptomatic patients: A systematic review and meta-analysis
  17. 15557
    “…Elevated BP accounted for nearly one-third cardiovascular mortality in stroke survivors, and particularly higher in young and middle-aged patients. National strategies targeting elevated BP are warranted to address the high stroke burden in China.…”
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    Prevalence, treatment, and attributed mortality of elevated blood pressure among a nationwide population-based cohort of stroke survivors in China
  18. 15558
    “…OBJECTIVE: We investigated effects of age and sex on five selected Q-Motor outcomes representing the two core Q-Motor tasks speeded finger tapping and grasping and lifting in a community sample of middle-aged to elderly adults. Furthermore, we explored effects of the potentially mediating variables educational attainment, alcohol consumption, smoking status, and depressive symptoms. …”
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    Effects of age and sex on outcomes of the Q-Motor speeded finger tapping and grasping and lifting tests-findings from the population-based BiDirect Study
  19. 15559
    “…We aimed to quantify the risk of birth defects in children born to middle‐aged mothers compared with that in children born to young or older mothers. …”
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    Congenital anomalies and maternal age: A systematic review and meta‐analysis of observational studies
  20. 15560
    “…However, most of the epidemiological evidence has been almost exclusively provided by research conducted in populations of youths or middle-aged adults. We tested the hypothesis that a large dietary share of UPF could be a risk factor also for vulnerable groups, as older adults (≥65 years). …”
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    Ultra-processed food consumption and survival in older Italians from the Moli-sani Study
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