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  1. 1541
    “…The findings revealed that Tai Chi significantly improved depression in middle-aged and older adults [SMD = -1.21, 95% CI (-1.59, -0.83), I(2) = 87.6%, P < 0.001]. …”
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    Effects of Tai Chi on depression of middle-aged and older adults: an updated systematic review and meta-analysis
  2. 1542
    “…We identified numerous methylation markers, pathways, and diseases associated with recent and cumulative marijuana use in middle-aged adults, providing additional insight into the association between marijuana use and the epigenome. …”
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    Genome-wide DNA methylation association study of recent and cumulative marijuana use in middle aged adults
  3. 1543
    “…We aimed to compare the predictive powers of the homeostatic model assessment for insulin resistance (HOMA-IR) and the metabolic score for insulin resistance (METS-IR) for CKD incidence in middle-aged and older adults. METHODS: This study used longitudinal prospective cohort data from the Korean Genome and Epidemiology Study. …”
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    Comparison of METS-IR and HOMA-IR for predicting new-onset CKD in middle-aged and older adults
  4. 1544
    “…The ε4-allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alz and negatively impacts cognition in middle-aged and older (MA+) adults. This study aimed to determine the impact of the APOE ε4-allele on verbal learning and memory in MA+ autistic adults (ages 40–71 years) compared to matched NT adults. …”
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    APOE ε4-Allele in Middle-Aged and Older Autistic Adults: Associations with Verbal Learning and Memory
  5. 1545
    “…We aimed to evaluate the association between RC levels in young adulthood and LV structure and function in middle age. METHODS: We included 3321 participants from the CARDIA study (Coronary Artery Risk Development in Young Adults) at baseline. …”
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    Remnant Cholesterol in Young Adulthood Is Associated With Left Ventricular Remodeling and Dysfunction in Middle Age: The CARDIA Study
  6. 1546
    “…Older adults had a greater ADL disability prevalence than middle-aged adults (p < 0.001). While older persons experienced a declining trend of ADL limitations (p < 0.001), middle-aged persons had an increasing trend (p < 0.001). …”
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    Prevalence and Trends of Basic Activities of Daily Living Limitations in Middle-Aged and Older Adults in the United States
  7. 1547
    “…On the whole, the present study demonstrates that the nutraceutical formulation can maintain or even increase TL and telomerase activity in middle-aged rats, indicating a potential role of this formula in the prevention and treatment of aging-related diseases.…”
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    A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats
  8. 1548
    “…However, evidence on the cost-effectiveness of drug treatment among young and middle-aged patients remains scarce. This study aimed to compare the cost-effectiveness of drug treatment vs. non-drug treatment for stage 1 hypertensive patients aged <60 years with high CVD risk. …”
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    Cost-effectiveness of drug treatment for young and middle-aged stage 1 hypertensive patients with high risk
  9. 1549
    “…Conclusions: Low fitness level, as captured by a maximal treadmill EST, is an independent risk predictor for MACE among middle-age individuals without known cardiovascular disease. …”
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    Cardiorespiratory Fitness and Risk of Cardiovascular Events and Mortality in Middle Age Patients without Known Cardiovascular Disease
  10. 1550
    “…BACKGROUND: Falls in older people have been characterized extensively in the literature, however little has been reported regarding falls in middle-aged and younger adults. The objective of this paper is to describe the perceived cause, environmental influences and resultant injuries of falls in 1497 young (20–45 years), middle-aged (46–65 years) and older (> 65 years) men and women from the Baltimore Longitudinal Study on Aging. …”
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    Falls in young, middle-aged and older community dwelling adults: perceived cause, environmental factors and injury
  11. 1551
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    The relationship between blood lead, blood pressure, stroke, and heart attacks in middle-aged British men.
  12. 1552
    “…In 110 consecutive, medicolegal autopsies of young and middle-aged women (range 20-54 years) the breasts were examined by an extensive histopathologic method and by correlative specimen radiography. …”
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    Breast cancer and atypia among young and middle-aged women: a study of 110 medicolegal autopsies.
  13. 1553
    “…The aim of the present study is to examine the effect of dietary antioxidants on knee structure in a cohort of healthy, middle-aged subjects with no clinical knee osteoarthritis. …”
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    Effect of antioxidants on knee cartilage and bone in healthy, middle-aged subjects: a cross-sectional study
  14. 1554
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    Circulating Matrix Metalloproteinase-9 Is Associated with Cardiovascular Risk Factors in a Middle-Aged Normal Population
  15. 1555
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    Association of body mass index and height with risk of prostate cancer among middle-aged Japanese men
  16. 1556
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    Is there an independent effect of polycystic ovary syndrome (PCOS) and menopause on the prevalence of subclinical atherosclerosis in middle aged women?
  17. 1557
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    Visual impairment from fibrous dysplasia in a middle-aged African man: a case report
  18. 1558
    “…CONCLUSIONS: Vitamin D deficiency is common in the middle-aged and elderly Chinese population, and a low 25(OH)D level is significantly associated with an increased risk of having metabolic syndrome and insulin resistance. …”
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    Plasma 25-Hydroxyvitamin D Concentration and Metabolic Syndrome Among Middle-Aged and Elderly Chinese Individuals
  19. 1559
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    Lipid and lipoprotein profiles among middle aged male smokers: a study from southern India
  20. 1560
    “…We aimed to investigate the associations of alcohol consumption with diabetes mellitus and impaired fasting glycemia (IFG) among middle-aged and elderly Chinese. METHODS: We examined 1,458 men and 1,831 women aged 50 to 70 from Beijing and Shanghai China in a cross-sectional survey. …”
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    Associations of alcohol consumption with diabetes mellitus and impaired fasting glycemia among middle-aged and elderly Chinese
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