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  1. 15601
    “…Despite believing certain COVID-19 myths, older adults with larger households and more fears regarding economic impacts of the pandemic (cluster 1) were more likely to ultimately to get vaccinated than cluster 3 (78% vs 66.4%; p<0.01), potentially due to employment requirements. Middle-aged women who are married or divorced and reported higher risk of gender-based violence in the home (cluster 2) were more likely than young adults (cluster 3) to report wanting to get the vaccine (50.5% vs 41.5%; p=0.014) but not more likely to have gotten it (69.3% vs 66.4%; p=0.41), indicating potential gaps in access and broader need for social support for this group. …”
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    Exploring COVID-19 vaccine hesitancy and uptake in Nairobi’s urban informal settlements: an unsupervised machine learning analysis of a longitudinal prospective cohort study from 2021 to 2022
  2. 15602
    “…Before and after the intervention, temperature sensation and body temperature parameters were measured just before bedtime; electroencephalogram measurements were taken during sleep; and subjective sleep surveys, including Oguri-Shirakawa-Azumi (OSA) sleep inventory (middle-aged and aged version) and visual analogue scale (VAS), were conducted immediately after waking up. …”
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    A two-week exercise intervention improves cold symptoms and sleep condition in cold-sensitive women
  3. 15603
    “…CONCLUSIONS: The findings reveal that a chat-based instant messaging support health education program may be effective for middle-aged and older patients with CKD. The use of a chat-based program with multiple promoting approaches is promising, and users’ evaluation is satisfactory. …”
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    User Evaluation of a Chat-Based Instant Messaging Support Health Education Program for Patients With Chronic Kidney Disease: Preliminary Findings of a Formative Study
  4. 15604
    “…Postoperative neurological dysfunction in elderly patients was similar to that in middle-aged and young patients.…”
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    Comparison of Short-Term Surgery Outcomes and Clinical Characteristics Between Elderly and Non-Elderly Patients with Middle Third Parasagittal and Parafalcine Meningiomas
  5. 15605
    “…We cannot advocate for either restricted- or unrestricted eating frequency to change markers of cardiometabolic health in healthy young to middle-aged adults. PROTOCOL REGISTRATION: CRD42019137938. …”
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    The effects of eating frequency on changes in body composition and cardiometabolic health in adults: a systematic review with meta-analysis of randomized trials
  6. 15606
    “…OBJECTIVES: The aim of this study was to assess the longitudinal association between loneliness, mental and physical ill-health indicators, lifestyle factors and mortality among middle-aged and older adults in Thailand. METHODS: We analyzed prospective cohort data of participants 45 years and older from three consecutive waves in 2015 (n = 5616), 2017 (n = 3600), and in 2020 (n = 2863) of the Health, Aging and Retirement in Thailand (HART) study. …”
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    Longitudinal associations of loneliness with mental ill-health, physical ill-health, lifestyle factors and mortality in ageing adults in Thailand
  7. 15607
    “…METHODS: The expression of IGF2 was examined in the liver of young (2–4 months), middle-aged (9–12 months), and old (24–26 months) C57BL/6 mice. …”
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    IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in d-galactose-induced aging mice
  8. 15608
    “…The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men. METHODS: Three thousand three hundred sixty nine men aged 40–79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. …”
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    Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study
  9. 15609
    “…CONCLUSION: Our findings indicate that measurement of NC may be useful for an earlier identification of unfavorable atherogenic metabolic profile in middle-aged individuals at lower cardiovascular risk level.…”
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    Neck circumference is associated with non-traditional cardiovascular risk factors in individuals at low-to-moderate cardiovascular risk: cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
  10. 15610
    “…Highest long-term CD4 cell counts were observed in middle-aged individuals. During the first 2 years, median CD8 cell counts converged toward median reference values. …”
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    Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1–Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy
  11. 15611
    por Schrijver, Lieske H, Olsson, Håkan, Phillips, Kelly-Anne, Terry, Mary Beth, Goldgar, David E, Kast, Karin, Engel, Christoph, Mooij, Thea M, Adlard, Julian, Barrowdale, Daniel, Davidson, Rosemarie, Eeles, Ros, Ellis, Steve, Evans, D Gareth, Frost, Debra, Izatt, Louise, Porteous, Mary E, Side, Lucy E, Walker, Lisa, Berthet, Pascaline, Bonadona, Valérie, Leroux, Dominique, Mouret-Fourme, Emmanuelle, Venat-Bouvet, Laurence, Buys, Saundra S, Southey, Melissa C, John, Esther M, Chung, Wendy K, Daly, Mary B, Bane, Anita, van Asperen, Christi J, Gómez Garcia, Encarna B, Mourits, Marian J E, van Os, Theo A M, Roos-Blom, Marie-José, Friedlander, Michael L, McLachlan, Sue-Anne, Singer, Christian F, Tan, Yen Y, Foretova, Lenka, Navratilova, Marie, Gerdes, Anne-Marie, Caldes, Trinidad, Simard, Jacques, Olah, Edith, Jakubowska, Anna, Arver, Brita, Osorio, Ana, Noguès, Catherine, Andrieu, Nadine, Easton, Douglas F, van Leeuwen, Flora E, Hopper, John L, Milne, Roger L, Antoniou, Antonis C, Rookus, Matti A
    Publicado 2018
    “…CONCLUSIONS: Prospective analyses did not show that past use of OCP is associated with an increased BC risk for BRCA1 mutation carriers in young middle-aged women (40–50 years). For BRCA2 mutation carriers, a causal association is also not likely at those ages. …”
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    Oral Contraceptive Use and Breast Cancer Risk: Retrospective and Prospective Analyses From a BRCA1 and BRCA2 Mutation Carrier Cohort Study
  12. 15612
    “…Thus, NW can be a primary tool to counteract the obesity and overweight state in middle-aged adults.…”
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    The effects of exercise and diet program in overweight people – Nordic walking versus walking
  13. 15613
    “…METHODS: Analyses were conducted across the life course using the ARIES cohort of mothers (n = 792) and children (n = 906), for whom DNA methylation and genetic profiles and BMI at multiple time points (3 in children at birth, in childhood and in adolescence; 2 in mothers during pregnancy and in middle age) were available. Genetic and DNA methylation scores for BMI were derived using published associations between BMI and DNA methylation and genotype. …”
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    The association of DNA methylation with body mass index: distinguishing between predictors and biomarkers
  14. 15614
    “…Established psychological treatments for PTSD (e.g. cognitive behaviour therapy, psychodynamic therapies) have been tested and assessed mainly with young and middle-aged adults; only very few studies examined them in old age. …”
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    Life review therapy for holocaust survivors (LRT-HS): study protocol for a randomised controlled trial
  15. 15615
    “…Analyses were stratified by age: young adults (aged 19–39 years), middle-aged adults (aged 40–59 years), and older adults (aged 60 years and older). …”
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    Low levels of serum urate are associated with a higher prevalence of depression in older adults: a nationwide cross-sectional study in Korea
  16. 15616
    “…CONCLUSION: Usual physical activity in this middle-aged and older population predicts lower future hospitalisations - time spent in hospital and number of admissions independently of behavioural and sociodemographic factors. …”
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    Usual physical activity and subsequent hospital usage over 20 years in a general population: the EPIC-Norfolk cohort
  17. 15617
    “…METHODS: We are recruiting cognitively normal, middle aged (40–65 years) sedentary adults with FH+. …”
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    The effect of physical activity on cognition relative to APOE genotype (PAAD-2): study protocol for a phase II randomized control trial
  18. 15618
    “…This study aims to determine the factors associated with sarcopenia-related parameters in middle-aged women identified with class II/III obesity (body mass index [BMI] ≥ 35 kg/m(2)). …”
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    What are the factors associated with sarcopenia-related variables in adult women with severe obesity?
  19. 15619
    “…CONCLUSIONS: Our findings indicate a correlation of low fasting levels of 2-h C-peptide as well as higher midnight cortisol levels with higher depression severity in middle-aged patients with T2DM.…”
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    Correlation of lower 2 h C-peptide and elevated evening cortisol with high levels of depression in type 2 diabetes mellitus
  20. 15620
    “…Carriers of a mutation in the responsible genes are at risk of reaching end-stage kidney disease typically in middle age. The frequency of this disease is assumed to be underestimated because of a lack of disease-specific signs. …”
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    Significance of kidney biopsy in autosomal dominant tubulointerstitial kidney disease-UMOD: is kidney biopsy truly nonspecific?
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