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  1. 15621
    “…While many people use cannabis without harm, adverse outcomes have been noted in a few populations, including middle-aged and older adults. Given that the current literature has neglected to study cannabis use among this population and between sexes, the objective of our study was to identify the prevalence, characteristics, and patterns of cannabis use among middle and older aged males and females prior to legalization in Canada. …”
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    Cannabis use and patterns among middle and older aged Canadians prior to legalization: a sex-specific analysis of the Canadian Tobacco, Alcohol and Drugs Survey
  2. 15622
    “…Analyses were done using 60 healthy individuals, including 23 monozygotic twin pairs, categorized into young (12–31 years) and middle-aged (42–59 years). Aging and CMV discordance were associated with increased immune diversity between monozygotic twins overall, and particularly strongly in various T cell populations. …”
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    Aging and CMV discordance are associated with increased immune diversity between monozygotic twins
  3. 15623
    “…RESULTS: A total of 1624 patients were included in the study: most were female (84.2%) and middle-aged, and mean disease duration was 10.5 years. …”
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    Treatment Satisfaction, Patient Preferences, and the Impact of Suboptimal Disease Control in a Large International Rheumatoid Arthritis Cohort: SENSE Study
  4. 15624
    “…The people with basic insurance had lower chances to face with responsibility-related SUN, while employed individuals were at risk to experience SUN. Although the middle-aged group had higher odds to experience SUN, the responsibility-related SUN were prevalent among elderly, while higher age groups had significant chance to be exposed to acceptability-related SUN. …”
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    Socioeconomic determinants of unmet need for outpatient healthcare services in Iran: a national cross-sectional study
  5. 15625
    “…METHODS: This study examined associations between sleep duration and physical fitness among young to middle-aged adults in Taiwan. A total of 42,781 Taiwanese adults aged 23–45 participated in the National Physical Fitness Examination Survey 2013 (NPFES-2013) in Taiwan between October 2013 and March 2014. …”
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    Associations of sleep duration with physical fitness performance and self-perception of health: a cross-sectional study of Taiwanese adults aged 23–45
  6. 15626
    “…CONCLUSIONS: These findings suggest that serum potassium level appears to predict long-term mortality in healthy middle-aged men, and it might imply future surveillance strategies for individuals with high serum potassium levels. …”
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    Fasting serum potassium and long-term mortality in healthy men
  7. 15627
    “…Iodine deficiency, elevated thyroid antibody levels, and middle age are the main risk factors for OH and GD. …”
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    Hyperthyroidism Prevalence in China After Universal Salt Iodization
  8. 15628
    “…CONCLUSION: MUAC is strongly correlated with ASMI among community-dwelling middle-aged and older adults in China. MUAC can be used as a simple screening instrument to ASMI for diagnosing sarcopenia, especially in men.…”
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    Mid-Upper Arm Circumference as an Alternative Screening Instrument to Appendicular Skeletal Muscle Mass Index for Diagnosing Sarcopenia
  9. 15629
    “…CASE PRESENTATION: A middle-aged female presented to the Emergency Department with wounds to her right hip and flank after suffering a shotgun injury. …”
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    A rare case of retained sabot after close-range shotgun injury
  10. 15630
    “…CONCLUSIONS: Pituicytomas are more common in middle-aged people and the sellar region. The clinical manifestations of pituicytomas are different, but no diagnostic clinical features have been identified other than an abnormally abundant blood supply. …”
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    Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data
  11. 15631
    “…Classes were labelled as “adult child parent relationship & younger informal caregiver”, “adult child parent relationship & middle aged informal caregiver”, “non family relationship & younger informal caregiver”, “couple & male informal caregiver of older age”, “couple & female informal caregiver of older age”, “couple & younger informal caregiver”. …”
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    Sociodemographic aspects and health care-related outcomes: a latent class analysis of informal dementia care dyads
  12. 15632
    por Liu, Haiyu, Zhang, Sai, Zhang, Liang
    Publicado 2021
    “…RESULTS: Hippocampal slices were prepared from young (21–28 days old), middle-aged (13–14 months old), and aged (24–26 months old) C57/BL6 mice. …”
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    Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular Mg(2+), Ca(2+), and K(+)
  13. 15633
    “…METHODS: The National Institute for Longevity Sciences-Longitudinal Study of Aging (NILS-LSA) enrolled community-dwelling middle-aged and older men and women who were randomly selected from Obu-City and Higashiura Town, Aichi, Japan. …”
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    Interaction between cognitive leisure activity and long-chain polyunsaturated fatty acid intake on global cognitive decline in a Japanese longitudinal cohort study: National Institute for Longevity Sciences-Longitudinal Study of Aging
  14. 15634
    “…Whether or not the measurement of PON1 activity in combination with a lipid profile and certain inflammatory markers could improve the prediction of cardiometabolic diseases in middle-aged individuals from the general population should be evaluated in clinical studies.…”
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    Association between inflammatory markers and serum paraoxonase and arylesterase activities in the general population: a cross-sectional study
  15. 15635
    “…METHODS: Participants were divided into three groups according to age: 20–30 years (Young); 45–55 years (Middle-aged); and ≥ 70 years (Old). The Sirt6 and telomerase serum concentrations were determined by ELISA. …”
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    Age-related changes of human serum Sirtuin6 in adults
  16. 15636
    “…RESULTS: The distribution of health-related behaviours and dietary habits was varied by sociodemographic groups. Middle-aged groups (41–60 years) were more likely to smoke (for men, 34.5%), use alcohol (for men, 22.5%), and have short sleep duration (for men, 36.3%; for women, 39.6%). …”
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    Sociodemographic disparity in health-related behaviours and dietary habits among public workers in China: a cross-sectional study
  17. 15637
    “…METHODS: The study included 322 middle-aged cognitively unimpaired participants from the ALFA + study, many within the Alzheimer’s continuum. …”
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    Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum
  18. 15638
    “…OBJECTIVE: As autoimmune encephalitis (AIE) can resemble neurodegenerative dementia syndromes, and patients do not always present as encephalitis, this study evaluates how frequently AIE mimics dementia and provides red flags for AIE in middle-aged and older patients. METHODS: In this nationwide observational cohort study, patients with anti–leucine-rich glioma-inactivated 1 (LGI1), anti–NMDA receptor (NMDAR), anti–gamma-aminobutyric acid B receptor (GABA(B)R), or anti–contactin-associated protein-like 2 (CASPR2) encephalitis were included. …”
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    Autoimmune Encephalitis Resembling Dementia Syndromes
  19. 15639
    “…As most studies investigating the effects of alcohol have focused on young/middle-aged populations, there is a dearth of information regarding the consequences of alcohol use in older consumers. …”
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    A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age
  20. 15640
    “…In detail, the high conditional quantiles of people in the middle age group are shorter than those of others while the low quantiles did not show the same differences. …”
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    Modeling the effect of age on quantiles of the incubation period distribution of COVID-19
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