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641por Kolarz, Bogdan, Ciesla, Marek, Dryglewska, Magdalena, Rosenthal, Ann K., Majdan, Maria“…OBJECTIVES: miR-155 plays a critical role in the inflammatory process and in diseases such as rheumatoid arthritis (RA). miR155 gene expression is regulated by its gene promoter region CpG island methylation. …”
Publicado 2020
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642por Li, Ming, Shan, Wulin, Hong, Bo, Zou, Jinglu, Li, Hong, Han, Dandan, Zhang, Yang, Li, Lailing, Li, Dan, Lin, Wenchu“…The expression of five miRNAs (miR-92b, miR-146a, miR-375, miR-1224, and miR-1246) was significantly upregulated in plasma after chemoresistance induction. …”
Publicado 2020
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643por Gyvyte, Ugne, Lukosevicius, Rokas, Inciuraite, Ruta, Streleckiene, Greta, Gudoityte, Greta, Bekampyte, Justina, Valentini, Serena, Salteniene, Violeta, Ruzgys, Paulius, Satkauskas, Saulius, Zviniene, Kristina, Kupcinskas, Juozas, Skieceviciene, Jurgita“…In this study, we aimed to investigate the role of two miRNAs strongly downregulated in GIST—miR-375-3p and miR-200b-3p—in the pathogenesis of GIST. …”
Publicado 2020
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644por Ciszkowicz, Ewa, Porzycki, Paweł, Semik, Małgorzata, Kaznowska, Ewa, Tyrka, Mirosław“…The present study clearly demonstrates that miR-93 and miR-375 could be taken into consideration as single blood-based non-invasive molecules to distinguish PCa from BPH patients. …”
Publicado 2020
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645“…Recent studies have shown that miR- 1 and miR-133 are key regulators of cardiac hypertrophy. …”
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646por Knyazeva, Margarita, Korobkina, Ekaterina, Karizky, Alexey, Sorokin, Maxim, Buzdin, Anton, Vorobyev, Sergey, Malek, Anastasia“…Coupled experimental and computational approaches identified reciprocal dysregulation of miR-146b and miR-451 as important attributes of follicular cell malignant transformation and follicular thyroid cancer progression. …”
Publicado 2020
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647por Hoshino, Isamu, Ishige, Fumitaka, Iwatate, Yosuke, Gunji, Hisashi, Shiratori, Fumiaki, Kuwayama, Naoki, Nabeya, Yoshihiro, Takeshita, Nobuyoshi, Matsubara, Hisahiro“…The function of microRNAs (miRs) is associated with the development and progression of various malignancies, with miRs presenting stably in the serum. …”
Publicado 2020
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648“…In comparison to the healthy controls, the expression levels of miR-217 were significantly upregulated, while miR-23b-3p were significantly downregulated in the exosomes and serum collected from PCa patients. …”
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649por Guo, Hongchang, Ma, Ke, Hao, Wenjing, Jiao, Yao, Li, Ping, Chen, Jing, Xu, Chen, Xu, Fu‐jian, Lau, Wayne Bond, Du, Jie, Ma, Xin‐liang, Li, Yulin“…CM‐specific mir15a/mir16‐1 knockout promoted cardiac hypertrophy and dysfunction after TAC. …”
Publicado 2020
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650por Wang, Ruran, Feng, Yanhua, Xu, Huaying, Huang, Haoran, Zhao, Shan, Wang, Yuhong, Li, Hongyan, Cao, Jian, Xu, Guoying, Huang, Shengnan“…The specific targets of two differentially expressed miRNAs in osteogenic or osteoclast differentiation were determined by bioinformatic prediction, and mRNA and protein detection. RESULTS: miR-708-5p and miR-708-3p were highly expressed in the bone tissue of OVX rats and OP patients. miR-708-5p negatively regulated osteoblast differentiation in bone marrow mesenchymal stem cells by targeting SMAD specific E3 ubiquitin protein ligase 2, while miR-708-3p positively regulated osteoclast differentiation in bone marrow monocytes by targeting cerebellar degeneration associated protein 1 antisense RNA. miR-708-5p and miR-708-3p were shown to originate from the same precursor miRNA and to have a synergistic effect on the development of osteoporosis with different temporal and spatial patterns. …”
Publicado 2020
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651“…OBJECTIVE: This study aims to determine the diagnosis and prediction value of serum miR-184 and miR-191 levels in patients with non-small-cell lung cancer (NSCLC). …”
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652“…Also, we found that miRNAs in miR-17/92 clusters are redundantly increased and there is an inverse correlation between Let-7 and miR-17/92 clusters in Fhit-expressing cells. …”
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653por Chouri, Eleni, Wang, Maojie, Hillen, Maarten R., Angiolilli, Chiara, Silva-Cardoso, Sandra C., Wichers, Catharina G. K., van der Kroef, Maarten, Bekker, Cornelis P. J., Cossu, Marta, van Bon, Lenny, Affandi, Alsya J., Carvalheiro, Tiago, Pandit, Aridaman, van Roon, Joel A. G., Beretta, Lorenzo, Burgering, Boudewijn M. T., Radstake, Timothy R. D. J., Rossato, Marzia“…The proteomic analysis identified USP24 as a novel target of miR-139-5p. The expression level of USP24 was inversely correlated with miR-139-5p expression in SSc patients and induced by TLR9 stimulation in healthy pDCs. …”
Publicado 2021
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654por Pietrus, Miłosz, Seweryn, Michał, Kapusta, Przemysław, Wołkow, Paweł, Pityński, Kazimierz, Wątor, Gracjan“…Validation of our results with external data (TCGA) gave us a reasonable gene overlap of which we selected two miRNAs (miR-375 and miR190b) that distinguish the high grade best from the low grade EC. …”
Publicado 2021
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655por Guo, Jinlan, Gan, Quan, Gan, Caibin, Zhang, Xiaoning, Ma, Xinping, Dong, Mingliang“…In this study, we investigated the role of lncRNA MIR205HG in melanomagenesis. Quantitative real-time PCR (qRT-PCR) analysis showed that MIR205HG levels were significantly upregulated in melanoma cell lines compared to normal human melanocytes. …”
Publicado 2021
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656Triple negative aggressive phenotype controlled by miR-135b and miR-365: new theranostics candidatespor Bertoli, Gloria, Cava, Claudia, Corsi, Fabio, Piccotti, Francesca, Martelli, Cristina, Ottobrini, Luisa, Vaira, Valentina, Castiglioni, Isabella“…We therefore identified two miRNAs, namely miR-135b and miR-365, with a central role in regulating the altered functional pathways in basal breast cancer. …”
Publicado 2021
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657MiR-30a and miR-200c differentiate cholangiocarcinomas from gastrointestinal cancer liver metastasespor Park, Jun Won, Jeong, Jong Min, Cho, Kye Soo, Cho, Soo Young, Cheon, Jae Hee, Choi, Dong Ho, Park, Sang Jae, Kim, Hark Kyun“…According to binary decision tree analyses, the overexpression of miR-30a and the underexpression of miR-200 family members (miR-200c and miR-141) differentiated intrahepatic cholangiocarcinomas from extrahepatic adenocarcinomas. …”
Publicado 2021
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658por Kiyoshima, Chihiro, Shirasu, Naoto, Urushiyama, Daichi, Fukagawa, Satoshi, Hirakawa, Toyofumi, Yoshikawa, Kenichi, Izuchi, Daisuke, Miyata, Kohei, Kurakazu, Masamitsu, Yotsumoto, Fusanori, Hiromatsu, Kenji, Nomiyama, Makoto, Eiji, Ohta, Hirose, Shinichi, Ogura, Yoshitoshi, Hayashi, Tetsuya, Hata, Kenichiro, Nabeshima, Kazuki, Yasunaga, Shin'ichiro, Miyamoto, Shingo“…BACKGROUND: This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis. …”
Publicado 2021
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659por Chen, Qihua, Deng, Na, Lu, Ke, Liao, Qiao, Long, Xiaoyan, Gou, Deming, Bi, Fangfang, Zhou, Jinxia“…Hence, elevated miR-133b and miR-221-3p potentially represent good biomarkers for early PD, and a combination of miR-133b, miR-221-3p and miR-4454 has the potential to serve as a non-invasive biomarker for PD diagnosis.…”
Publicado 2021
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660por Pozzo, Enrico, Giarratana, Nefele, Sassi, Gabriele, Elmastas, Merve, Killian, Theo, Wang, Chao-chi, Marini, Vittoria, Ronzoni, Flavio, Yustein, Jason, Uyttebroeck, Anne, Sampaolesi, MaurilioEnlace del recurso
Publicado 2021
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