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121por Chandra, Shruti, Arpa, Cristina, Menon, Deepthy, Khalid, Hagar, Hamilton, Robin, Nicholson, Luke, Pal, Bishwanath, Fasolo, Sandro, Hykin, Philip, Keane, Pearse A., Sivaprasad, Sobha“…Neovascular AMD patients initiated on intravitreal anti-VEGF injections in 2008–2009 and continued to be followed up for at least 10 years were included in this study. METHODS: The Moorfields OpenEyes database was searched for all patients who were initiated on anti-VEGF therapy for neovascular AMD in 2008–2009 and the visual acuity (VA) in Early Diabetic Retinopathy Study (ETDRS) letters and injection records were analyzed for those who have had at least 10-year follow-up. …”
Publicado 2020
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122por Han, Ji Eun Diana, Liu, Xiaoxuan, Bunce, Catey, Douiri, Abdel, Vale, Luke, Blandford, Ann, Lawrenson, John, Hussain, Rima, Grimaldi, Gabriela, Learoyd, Annastazia E, Kernohan, Ashleigh, Dinah, Christiana, Minos, Evangelos, Sim, Dawn, Aslam, Tariq, Patel, Praveen J, Denniston, Alastair K, Keane, Pearse A, Balaskas, Konstantinos“…OCT scans will be interpreted by the AI DSS, which provides a diagnosis and referral decision and the primary outcome for the AI diagnostic study is diagnostic accuracy of the referral decision made by the Moorfields-DeepMind AI system. Secondary outcomes relate to inappropriate referral rate, cost-effectiveness analyses and human–computer interaction (HCI) analyses. …”
Publicado 2022
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123por Wagner, Siegfried Karl, Hughes, Fintan, Cortina-Borja, Mario, Pontikos, Nikolas, Struyven, Robbert, Liu, Xiaoxuan, Montgomery, Hugh, Alexander, Daniel C, Topol, Eric, Petersen, Steffen Erhard, Balaskas, Konstantinos, Hindley, Jack, Petzold, Axel, Rahi, Jugnoo S, Denniston, Alastair K, Keane, Pearse A“…PARTICIPANTS: Between 1 January 2008 and 1 April 2018, 353 157 participants aged 40 years or older, who attended Moorfields Eye Hospital NHS Foundation Trust, a tertiary ophthalmic institution incorporating a principal central site, four district hubs and five satellite clinics in and around London, UK serving a catchment population of approximately six million people. …”
Publicado 2022
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124por Abbas, Abdallah, O’Byrne, Ciara, Fu, Dun Jack, Moraes, Gabriella, Balaskas, Konstantinos, Struyven, Robbert, Beqiri, Sara, Wagner, Siegfried K., Korot, Edward, Keane, Pearse A.“…RESULTS: Our study included 1631 eyes from patients attending Moorfields Eye Hospital. The AutoML model (area under the curve [AUC], 0.849) achieved a highly similar performance to the XGBoost model (AUC, 0.847). …”
Publicado 2022
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125por Cole, Yasemin C., Zhang, Yu-Zhi, Gallo, Beatrice, Januszewski, Adam P., Nastase, Anca, Essex, David J., Thaung, Caroline M. H., Cohen, Victoria M. L., Sagoo, Mandeep S., Bowcock, Anne M.“…Tumor DNA from a cohort of 100 UM patients from Moorfields Biobank (UK) that had undergone enucleation were sequenced for known UM driver genes (BAP1, SF3B1, EIF1AX, GNAQ, and GNA11). …”
Publicado 2022
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126por Brady, Louca-Mai, Miller, Jacqueline, McFarlane-Rose, Eleri, Noor, Jasmine, Noor, Rhianne, Dahlmann-Noor, Annegret“…Underpinned by children’s rights and a co-production ethos this paper, co-authored with young evaluators, explores the learning from a co-produced evaluation of eyeYPAG, a young persons’ research advisory group (YPAG) for eye and vision research based at Moorfields Eye Hospital, London, UK. METHODS: A team of young evaluators, supported by the eyeYPAG facilitator, conducted focus groups and online surveys with YPAG members, their parents and carers, researchers, group facilitators and funders. …”
Publicado 2023
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127por Kyari, Fatima, Tafida, Abubakar, Sivasubramaniam, Selvaraj, Murthy, Gudlavalleti VS, Peto, Tunde, Gilbert, Clare E“…Images were graded by Moorfields Eye Hospital Reading Centre. Participants were defined as having diabetes if they were previously diagnosed or RBG>11.1mmol/l or had DR. …”
Publicado 2014
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128por Cillino, Salvatore, Casuccio, Alessandra, Di Pace, Francesco, Cagini, Carlo, Ferraro, Lucia Lee, Cillino, Giovanni“…Secondary outcomes: visual acuity (VA), mean deviation (MD), bleb evaluation, according to Moorfields Bleb Grading System (MBGS); spectral domain OCT (SD-OCT) bleb examination; number of glaucoma medications; frequency of postoperative complications. …”
Publicado 2016
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129por Pontikos, Nikolas, Arno, Gavin, Jurkute, Neringa, Schiff, Elena, Ba-Abbad, Rola, Malka, Samantha, Gimenez, Ainoa, Georgiou, Michalis, Wright, Genevieve, Armengol, Monica, Knight, Hannah, Katz, Menachem, Moosajee, Mariya, Yu-Wai-Man, Patrick, Moore, Anthony T., Michaelides, Michel, Webster, Andrew R., Mahroo, Omar A.“…PARTICIPANTS: Patients and relatives managed in the Genetics Service of Moorfields Eye Hospital in whom a molecular diagnosis had been identified. …”
Publicado 2020
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130por Wilson, Marc, Chopra, Reena, Wilson, Megan Z., Cooper, Charlotte, MacWilliams, Patricia, Liu, Yun, Wulczyn, Ellery, Florea, Daniela, Hughes, Cían O., Karthikesalingam, Alan, Khalid, Hagar, Vermeirsch, Sandra, Nicholson, Luke, Keane, Pearse A., Balaskas, Konstantinos, Kelly, Christopher J.“…DESIGN, SETTING, PARTICIPANTS: This diagnostic study used OCT data from 173 patients with a total of 15 558 B-scans, treated at Moorfields Eye Hospital. The data set included 2 common OCT devices and 2 macular conditions: wet age-related macular degeneration (107 scans) and diabetic macular edema (66 scans), covering the full range of severity, and from 3 points during treatment. …”
Publicado 2021
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131por Korot, Edward, Pontikos, Nikolas, Drawnel, Faye M., Jaber, Aljazy, Fu, Dun Jack, Zhang, Gongyu, Miranda, Marco A., Liefers, Bart, Glinton, Sophie, Wagner, Siegfried K., Struyven, Robbert, Kilduff, Caroline, Moshfeghi, Darius M., Keane, Pearse A., Sim, Dawn A., Thomas, Peter B. M., Balaskas, Konstantinos“…DESIGN, SETTING, AND PARTICIPANTS: In this cohort and survey study, consecutive adult patients attending Moorfields Eye Hospital receiving intravitreal injections for retinal disease between May 2020 and February 2021 were included. …”
Publicado 2021
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132por Taylor, Laura J., Josan, Amandeep S., Stratton, Irene, Jolly, Jasleen K., MacLaren, Robert E.“…Part one includes examining standard visual acuity, low luminance visual acuity, the Moorfields acuity chart visual acuity, mesopic microperimetry and three separate patient reported outcome measures. …”
Publicado 2023
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133por Wright, David M., Chakravarthy, Usha, Das, Radha, Graham, Katie W., Naskas, Timos T., Perais, Jennifer, Kee, Frank, Peto, Tunde, Hogg, Ruth E.“…Reading index was highly ranked for tasks A and B, whereas near visual acuity and Moorfields chart acuity were important for task C. Microperimetry variables ranked highly for all three tasks, but this was partly due to a data artefact (a large proportion of missing values). …”
Publicado 2023
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134por Dunbar, Hannah M. P., Behning, Charlotte, Abdirahman, Amina, Higgins, Bethany E., Binns, Alison M., Terheyden, Jan H., Zakaria, Nadia, Poor, Stephen, Finger, Robert P., Leal, Sergio, Holz, Frank G., Schmid, Matthias, Crabb, David P., Rubin, Gary S., Luhmann, Ulrich F. O.“…The repeatability and discriminatory power of 5 simple chart-based assessments of VF (best-corrected visual acuity [BCVA], low-luminance visual acuity [LLVA], Moorfields Acuity Test [MAT], Pelli-Robson Contrast Sensitivity [CS], and International Reading Speed Test [IReST]) were assessed in a repeated-measures design. …”
Publicado 2022
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135por Veturi, Yoga Advaith, Woof, William, Lazebnik, Teddy, Moghul, Ismail, Woodward-Court, Peter, Wagner, Siegfried K., Cabral de Guimarães, Thales Antonio, Daich Varela, Malena, Liefers, Bart, Patel, Praveen J., Beck, Stephan, Webster, Andrew R., Mahroo, Omar, Keane, Pearse A., Michaelides, Michel, Balaskas, Konstantinos, Pontikos, Nikolas“…DESIGN: Diagnostic study of gene-labeled fundus autofluorescence (FAF) IRD images using deep learning. PARTICIPANTS: Moorfields Eye Hospital (MEH) dataset of 15 692 FAF images obtained from 1800 patients with confirmed genetic diagnosis of 1 of 36 IRD genes. …”
Publicado 2022
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136por Wagner, Siegfried K, Liefers, Bart, Radia, Meera, Zhang, Gongyu, Struyven, Robbert, Faes, Livia, Than, Jonathan, Balal, Shafi, Hennings, Charlie, Kilduff, Caroline, Pooprasert, Pakinee, Glinton, Sophie, Arunakirinathan, Meena, Giannakis, Periklis, Braimah, Imoro Zeba, Ahmed, Islam S H, Al-Feky, Mariam, Khalid, Hagar, Ferraz, Daniel, Vieira, Juliana, Jorge, Rodrigo, Husain, Shahid, Ravelo, Janette, Hinds, Anne-Marie, Henderson, Robert, Patel, Himanshu I, Ostmo, Susan, Campbell, J Peter, Pontikos, Nikolas, Patel, Praveen J, Keane, Pearse A, Adams, Gill, Balaskas, Konstantinos“…FUNDING: National Institute for Health Research Biomedical Research Centre based at Moorfields Eye Hospital NHS Foundation Trust and the University College London Institute of Ophthalmology.…”
Publicado 2023
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137por Benjamin, Laura A., Paterson, Ross W., Moll, Rachel, Pericleous, Charis, Brown, Rachel, Mehta, Puja R., Athauda, Dilan, Ziff, Oliver J., Heaney, Judith, Checkley, Anna M., Houlihan, Catherine F., Chou, Michael, Heslegrave, Amanda J., Chandratheva, Arvind, Michael, Benedict D., Blennow, Kaj, Vivekanandam, Vinojini, Foulkes, Alexander, Mummery, Catherine J., Lunn, Michael P., Keddie, Stephen, Spyer, Moira J., Mckinnon, Tom, Hart, Melanie, Carletti, Francesco, Jäger, Hans Rolf, Manji, Hadi, Zandi, Michael S., Werring, David J., Nastouli, Eleni, Simister, Robert, Solomon, Tom, Zetterberg, Henrik, Schott, Jonathan M., Cohen, Hannah, Efthymiou, Maria“…FUNDING: This work is supported by UCL Queen Square Biomedical Research Centre (BRC) and Moorfields BRC grants (#560441 and #557595). LB is supported by a Wellcome Trust Fellowship (222102/Z/20/Z). …”
Publicado 2021
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138por Arnold, Jason W., Roach, Jeffery, Fabela, Salvador, Moorfield, Emily, Ding, Shengli, Blue, Eric, Dagher, Suzanne, Magness, Scott, Tamayo, Rita, Bruno-Barcena, Jose M., Azcarate-Peril, M. AndreaEnlace del recurso
Publicado 2021
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139por Valente, Sabrina, Ciavarella, Carmen, Astolfi, Gloria, Bergantin, Elisa, Curti, Nico, Buzzi, Marina, Fontana, Luigi, Versura, Piera“…The human MIO-M1 glial cell line (Moorfield/Institute of Ophthalmology, London, UK) was incubated with FF and FD products and evaluated for cell migration with scratch-induced wounding (IncuCyte S3 Essen BioScience), proliferation with cyclin A2 and D1 gene expression, and activation with vimentin and GFAP gene expression. …”
Publicado 2022
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140por Arnold, Jason W., Roach, Jeffery, Fabela, Salvador, Moorfield, Emily, Ding, Shengli, Blue, Eric, Dagher, Suzanne, Magness, Scott, Tamayo, Rita, Bruno-Barcena, Jose M., Azcarate-Peril, M. AndreaEnlace del recurso
Publicado 2021
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