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  1. 461
    “…We show that the same phosphomimicking mutations disrupt the NEC-membrane interactions and inhibit NEC-mediated budding in vitro, providing a biophysical explanation for the in vivo phenomenon. …”
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    Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering
  2. 462
    “…Necrotizing enterocolitis (NEC) is a significant cause of mortality and morbidity in preterm infants. …”
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    The Role of Dietary Fats in the Development and Prevention of Necrotizing Enterocolitis
  3. 463
    “…Necrotizing enterocolitis (NEC) is a rare but devastating gastrointestinal disease that predominately affects preterm neonates. …”
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    Recent Potential Noninvasive Biomarkers in Necrotizing Enterocolitis
  4. 464
    “…Necrotizing enterocolitis (NEC) is one of the most prevalent neonatal gastrointestinal disorders. …”
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    Current therapy option for necrotizing enterocolitis: Practicalities and challenge
  5. 465
    “…As understanding of the microbiome has increased, probiotics have been hypothesized as a possible strategy for decreasing rates of NEC, and several studies have noted significant decreases in rates of NEC after initiation of probiotics in preterm infants. …”
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    Routine Administration of a Multispecies Probiotic Containing Bifidobacterium and Lactobacillus to Very Low Birth Weight Infants Had No Significant Impact on the Incidence of Necrotizing Enterocolitis
  6. 466
    por Underwood, Mark A.
    Publicado 2012
    “…Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. …”
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    Paneth cells and necrotizing enterocolitis
  7. 467
    “…BACKGROUND: In the present study, we demonstrate, in rigorous fashion, that human monocyte-derived immature dendritic cells (DCs) can efficiently cross-present tumor-associated antigens when co-cultured with a mixture of human melanoma cells rendered apoptotic/necrotic by γ irradiation (Apo-Nec cells). METHODS: We evaluated the phagocytosis of Apo-Nec cells by FACS after PKH26 and PKH67 staining of DCs and Apo-Nec cells at different times of coculture. …”
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    Monocyte-derived dendritic cells loaded with a mixture of apoptotic/necrotic melanoma cells efficiently cross-present gp100 and MART-1 antigens to specific CD8(+ )T lymphocytes
  8. 468
    “…These limitations of Nec-1 have driven an effort to identify next-generation tools to study RIP1 function, and have led to the identification of 7-Cl-O-Nec-1 (Nec-1s), which has improved pharmacokinetic properties and lacks IDO inhibitory activity. …”
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    Characterization of GSK′963: a structurally distinct, potent and selective inhibitor of RIP1 kinase
  9. 469
    “…Necrotizing enterocolitis (NEC) is an acute devastating neonatal intestinal inflammatory disorder. …”
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    Impact of Docosahexaenoic acid supplementation on proinflammatory cytokines release and the development of Necrotizing enterocolitis in preterm Neonates: A randomized controlled study
  10. 470
    “…Western blotting detected CXCL1 and CXCR2 expression in NEC, HIBI, and NEC + HIBI rat intestinal and brain tissues. …”
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    CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis
  11. 471
    “…Background: Necrotizing enterocolitis (NEC) is still one of the leading causes of neonatal death. …”
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    Occurrence of Neonatal Necrotizing Enterocolitis in Premature Neonates and Gut Microbiota: A Case–Control Prospective Multicenter Study
  12. 472
    “…BACKGROUND: The appropriate use of antibiotics for preterm infants, which are highly susceptible to develop necrotizing enterocolitis (NEC), is not clear. While antibiotic therapy is commonly used in neonates with NEC symptoms and sepsis, it remains unknown how antibiotics may affect the intestine and NEC sensitivity. …”
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    Antibiotics Increase Gut Metabolism and Antioxidant Proteins and Decrease Acute Phase Response and Necrotizing Enterocolitis in Preterm Neonates
  13. 473
    “…Objective. Necrostatin-1 (Nec-1) inhibits receptor-interacting protein 1 (RIP1) kinase and programmed necrosis. …”
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    Protective Effects of Necrostatin-1 against Concanavalin A-Induced Acute Hepatic Injury in Mice
  14. 474
    “…Breast milk is the most effective strategy to protect infants against necrotizing enterocolitis (NEC), a devastating disease which is characterized by severe intestinal necrosis. …”
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    Breast milk protects against the development of necrotizing enterocolitis through inhibition of Toll Like Receptor 4 in the intestinal epithelium via activation of the epidermal growth factor receptor
  15. 475
    “…BACKGROUND: Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants. …”
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    Smad7 Interrupts TGF-β Signaling in Intestinal Macrophages and Promotes Inflammatory Activation of these Cells during Necrotizing Enterocolitis
  16. 476
    “…MAIN OUTCOME MEASURES: Incidences of NEC, overall mortality, mortality following NEC and nosocomial BSI. …”
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    Protective Effect of Dual-Strain Probiotics in Preterm Infants: A Multi-Center Time Series Analysis
  17. 477
    por Wang, Li, Li, Yinghui, Liu, Jian
    Publicado 2016
    “…OBJECTIVE: To summarize abdominal plain X-rays and ultrasound characteristics of 144 cases of Neonatal Necrotizing Enterocolitis (NEC) and to analyze diagnostic value and disease evaluation significance of abdominal ultrasound inspection for NEC. …”
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    Diagnostic value and disease evaluation significance of abdominal ultrasound inspection for neonatal necrotizing enterocolitis
  18. 478
    “…L-arginine concentrations are decreased in preterm infants with necrotizing enterocolitis (NEC). In this multicenter prospective study, we investigated the association of the p.Thr1406Asn polymorphism with NEC in 477 preterm infants (36 cases of NEC) from 4 European neonatal intensive care units (Maastricht, Las Palmas de Gran Canaria, Mantova, and Milan). …”
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    Association between the p.Thr1406Asn polymorphism of the carbamoyl-phosphate synthetase 1 gene and necrotizing enterocolitis: A prospective multicenter study
  19. 479
    “…Necroptosis is a programmed necrosis, regulated by receptor interacting protein kinase 1(RIP1) and receptor interacting protein kinase 3(RIP3), and could be inhibited by necrostatin-1(Nec-1) specifically. This study aims to evaluate the effect of Nec-1 on LPS-treated periodontal ligament stem cells (PDLSCs). …”
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    Necrostatin-1 promotes ectopic periodontal tissue like structure regeneration in LPS-treated PDLSCs
  20. 480
    “…BACKGROUND: Neuroendocrine carcinoma (NEC) arising from the esophagus (EsoNEC) is extreme rare, accounting for approximately 1% of esophageal cancer. …”
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    Clinical outcomes of locally advanced esophageal neuroendocrine carcinoma treated with chemoradiotherapy
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