Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis

por Lenz, Jonathan, Liefke, Robert, Funk, Julianne, Shoup, Samuel, Nist, Andrea, Stiewe, Thorsten, Schulz, Robert, Tokusumi, Yumiko, Albert, Lea, Raifer, Hartmann, Förstemann, Klaus, Vázquez, Olalla, Tokusumi, Tsuyoshi, Fossett, Nancy, Brehm, Alexander
Publicado 2021

The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state

por Adhikary, Till, Wortmann, Annika, Schumann, Tim, Finkernagel, Florian, Lieber, Sonja, Roth, Katrin, Toth, Philipp M., Diederich, Wibke E., Nist, Andrea, Stiewe, Thorsten, Kleinesudeik, Lara, Reinartz, Silke, Müller-Brüsselbach, Sabine, Müller, Rolf
Publicado 2015

Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses

por Timofeev, Oleg, Klimovich, Boris, Schneikert, Jean, Wanzel, Michael, Pavlakis, Evangelos, Noll, Julia, Mutlu, Samet, Elmshäuser, Sabrina, Nist, Andrea, Mernberger, Marco, Lamp, Boris, Wenig, Ulrich, Brobeil, Alexander, Gattenlöhner, Stefan, Köhler, Kernt, Stiewe, Thorsten
Publicado 2019

JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions

por Procida, Tara, Friedrich, Tobias, Jack, Antonia P. M., Peritore, Martina, Bönisch, Clemens, Eberl, H. Christian, Daus, Nadine, Kletenkov, Konstantin, Nist, Andrea, Stiewe, Thorsten, Borggrefe, Tilman, Mann, Matthias, Bartkuhn, Marek, Hake, Sandra B.
Publicado 2021

Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK‐STAT signaling in macrophages by perturbing lipid raft structures

por Hammoud, Mohamad K., Dietze, Raimund, Pesek, Jelena, Finkernagel, Florian, Unger, Annika, Bieringer, Tim, Nist, Andrea, Stiewe, Thorsten, Bhagwat, Aditya M., Nockher, Wolfgang Andreas, Reinartz, Silke, Müller‐Brüsselbach, Sabine, Graumann, Johannes, Müller, Rolf
Publicado 2022

CRISPR-Cas9-based target validation for p53-reactivating model compounds

por Wanzel, Michael, Vischedyk, Jonas B, Gittler, Miriam P, Gremke, Niklas, Seiz, Julia R, Hefter, Mirjam, Noack, Magdalena, Savai, Rajkumar, Mernberger, Marco, Charles, Joël P, Schneikert, Jean, Bretz, Anne Catherine, Nist, Andrea, Stiewe, Thorsten
Publicado 2015

Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response

por Giaimo, Benedetto Daniele, Ferrante, Francesca, Vallejo, Diana M, Hein, Kerstin, Gutierrez-Perez, Irene, Nist, Andrea, Stiewe, Thorsten, Mittler, Gerhard, Herold, Susanne, Zimmermann, Tobias, Bartkuhn, Marek, Schwarz, Peggy, Oswald, Franz, Dominguez, Maria, Borggrefe, Tilman
Publicado 2018

Upregulation of mesothelial genes in ovarian carcinoma cells is associated with an unfavorable clinical outcome and the promotion of cancer cell adhesion

por Ojasalu, Kaire, Brehm, Corinna, Hartung, Kristin, Nischak, Maximilian, Finkernagel, Florian, Rexin, Peter, Nist, Andrea, Pavlakis, Evangelos, Stiewe, Thorsten, Jansen, Julia M., Wagner, Uwe, Gattenlöhner, Stefan, Bräuninger, Andreas, Müller‐Brüsselbach, Sabine, Reinartz, Silke, Müller, Rolf
Publicado 2020

Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with infl...

por Bertrams, Wilhelm, Hönzke, Katja, Obermayer, Benedikt, Tönnies, Mario, Bauer, Torsten T., Schneider, Paul, Neudecker, Jens, Rückert, Jens C., Stiewe, Thorsten, Nist, Andrea, Eggeling, Stephan, Suttorp, Norbert, Wolff, Thorsten, Hippenstiel, Stefan, Schmeck, Bernd, Hocke, Andreas C.
Publicado 2022

Cyclophilin inhibitors restrict Middle East respiratory syndrome coronavirus via interferon-λ in vitro and in mice

por Sauerhering, Lucie, Kupke, Alexandra, Meier, Lars, Dietzel, Erik, Hoppe, Judith, Gruber, Achim D., Gattenloehner, Stefan, Witte, Biruta, Fink, Ludger, Hofmann, Nina, Zimmermann, Tobias, Goesmann, Alexander, Nist, Andrea, Stiewe, Thorsten, Becker, Stephan, Herold, Susanne, Peteranderl, Christin
Publicado 2020

The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands

por Stielow, Bastian, Zhou, Yuqiao, Cao, Yinghua, Simon, Clara, Pogoda, Hans-Martin, Jiang, Junyi, Ren, Yanpeng, Phanor, Sabrina Keita, Rohner, Iris, Nist, Andrea, Stiewe, Thorsten, Hammerschmidt, Matthias, Shi, Yang, Bulyk, Martha L., Wang, Zhanxin, Liefke, Robert
Publicado 2021

A single-cell level comparison of human inner ear organoids with the human cochlea and vestibular organs

por van der Valk, Wouter H., van Beelen, Edward S.A., Steinhart, Matthew R., Nist-Lund, Carl, Osorio, Daniel, de Groot, John C.M.J, Sun, Liang, van Benthem, Peter Paul G., Koehler, Karl R., Locher, Heiko
Publicado 2023

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain

por Weber, Lisa Marie, Jia, Yulin, Stielow, Bastian, Gisselbrecht, Stephen S, Cao, Yinghua, Ren, Yanpeng, Rohner, Iris, King, Jessica, Rothman, Elisabeth, Fischer, Sabrina, Simon, Clara, Forné, Ignasi, Nist, Andrea, Stiewe, Thorsten, Bulyk, Martha L, Wang, Zhanxin, Liefke, Robert
Publicado 2022

Monitoring autochthonous lung tumors induced by somatic CRISPR gene editing in mice using a secreted luciferase

por Merle, Nastasja, Elmshäuser, Sabrina, Strassheimer, Florian, Wanzel, Michael, König, Alexander M., Funk, Julianne, Neumann, Michelle, Kochhan, Katharina, Helmprobst, Frederik, Pagenstecher, Axel, Nist, Andrea, Mernberger, Marco, Schneider, André, Braun, Thomas, Borggrefe, Tilman, Savai, Rajkumar, Timofeev, Oleg, Stiewe, Thorsten
Publicado 2022

Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment

por Schumann, Tim, Adhikary, Till, Wortmann, Annika, Finkernagel, Florian, Lieber, Sonja, Schnitzer, Evelyn, Legrand, Nathalie, Schober, Yvonne, Nockher, W. Andreas, Toth, Philipp M., Diederich, Wibke E., Nist, Andrea, Stiewe, Thorsten, Wagner, Uwe, Reinartz, Silke, Müller-Brüsselbach, Sabine, Müller, Rolf
Publicado 2015

Specific allelic variants of SNPs in the MDM2 and MDMX genes are associated with earlier tumor onset and progression in Caucasian breast cancer patients

por Bauer, Marcus, Kantelhardt, Eva Johanna, Stiewe, Thorsten, Nist, Andrea, Mernberger, Marco, Politt, Katharina, Hanf, Volker, Lantzsch, Tilmann, Uleer, Christoph, Peschel, Susanne, John, Jutta, Buchmann, Jörg, Weigert, Edith, Bürrig, Karl-Friedrich, Wickenhauser, Claudia, Thomssen, Christoph, Bartel, Frank, Vetter, Martina
Publicado 2019

Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53

por Schuldner, Maximiliane, Dörsam, Bastian, Shatnyeva, Olga, Reiners, Katrin S., Kubarenko, Andriy, Hansen, Hinrich P., Finkernagel, Florian, Roth, Katrin, Theurich, Sebastian, Nist, Andrea, Stiewe, Thorsten, Paschen, Annette, Knittel, Gero, Reinhardt, Hans C., Müller, Rolf, Hallek, Michael, von Strandmann, Elke Pogge
Publicado 2019

Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer

por Dietze, Raimund, Hammoud, Mohamad K., Gómez-Serrano, María, Unger, Annika, Bieringer, Tim, Finkernagel, Florian, Sokol, Anna M., Nist, Andrea, Stiewe, Thorsten, Reinartz, Silke, Ponath, Viviane, Preußer, Christian, von Strandmann, Elke Pogge, Müller-Brüsselbach, Sabine, Graumann, Johannes, Müller, Rolf
Publicado 2021

Cell type‐selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment

por Reinartz, Silke, Lieber, Sonja, Pesek, Jelena, Brandt, Dominique T., Asafova, Alina, Finkernagel, Florian, Watzer, Bernard, Nockher, Wolfgang Andreas, Nist, Andrea, Stiewe, Thorsten, Jansen, Julia M., Wagner, Uwe, Konzer, Anne, Graumann, Johannes, Grosse, Robert, Worzfeld, Thomas, Müller‐Brüsselbach, Sabine, Müller, Rolf
Publicado 2018

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

por György, Bence, Nist-Lund, Carl, Pan, Bifeng, Asai, Yukako, Karavitaki, K. Domenica, Kleinstiver, Benjamin, Garcia, Sara P., Zaborowski, Mikołaj P., Solanes, Paola, Spataro, Sofia, Schneider, Bernard, Joung, J. Keith, Geleoc, Gwenaelle S.G., Holt, Jeffrey R., Corey, David P.
Publicado 2019