“…[Image: see text] We describe the energetic landscape beyond the solid-state dynamic behavior of a cyclic hexapeptoid decorated with four propargyl and two methoxyethyl side chains, namely, cyclo-(Nme-Npa(2))(2), Nme = N-(methoxyethyl)glycine, Npa = N-(propargyl)glycine. …”
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“…We report the synthesis of the organo-osmium anticancer complex [Os(η(6)-p-cym)(N,N-azpy-NMe(2))Br]PF(6) (1) containing natural abundance (187)Os (1.96%), and isotopically-enriched (98%) [(187)Os]-1. …”
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“…In this study, to clarify the mechanism underlying succinimide formation for the peptide bond cleavage of the Asn residue, we performed quantum chemical calculations on the model compound Ace-Asn-Gly-Nme (Ace = acetyl and Nme = methylamino). The density functional theory with the B3LYP/6-31+G(d,p) level of theory was used to obtain optimized geometries. …”
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“…ICAP-1 controls integrin endocytosis by interacting with NME2, a key regulator of dynamin-dependent clathrin-coated pits fission. …”
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“…The significantly higher serum NME1 concentrations and the serum CLN5/zo-1 index were observed in FGR pregnancy with BS, as compared to the FGR group without BS. …”
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“…The S. muelleri Acr is the most potent NmeCas9 inhibitor identified to date. Although inhibition of NmeCas9 by anti-CRISPRs from H. parainfluenzae and S. muelleri reveals cross-species inhibitory activity, more distantly related type II-C Cas9s are not inhibited by these proteins. …”
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“…METHODS: Based on 13 years of active/prospective surveillance (2005–2018) in children > 7 days and < 16 years of age at the General Hospital of Tijuana, we identified 51 cases of MeM (25% lethality), and 30 non-meningococcal meningitis (NMeM). Association between cases per month of MeM and NMeM, with SAWs seasons (from a 65 years review: Guzman-Morales J, et al. …”
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“…The neuro-mechanical efficiency ratio (NME, ΔPaw/EAdi(max)) was also computed. The evolution over time of these indices in a group of children in the pediatric intensive care unit (PICU) was primarily described. …”
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“…Results: We found an association between SAWs and MeM, but not with NMeM (RR = 2.06, p = 0.02 (95% CI 1.1 to 3.8), which may partially explain the high endemicity of this deadly disease in this part of the globe. …”
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“…Urine peptidome profiling showed that the proteins ITIH1, PDCD1LG2, NME1-NME2, and CSPG4 were significantly differentially expressed between the HH and HL groups, which was tested using ELISA. …”
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“…[Image: see text] The two commercially available zirconium complexes tetrakis(dimethylamido)zirconium, Zr(NMe(2))(4), and tetrabenzylzirconium, ZrBn(4), were investigated for their utility as starting materials in the synthesis of bis(pyridine dipyrrolide)zirconium photosensitizers, Zr(PDP)(2). …”
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“…However, there exists alternative methods superior to NME in terms of evaluating the model’s efficacy. …”
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“…A number of known or putative tumour-suppressor genes including NF1, BRCA1, NME1, NME2 and prohibitin are present on the long arm of chromosome 17, and this region has not been extensively analysed in colorectal tumours. …”
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“…Interestingly, gene SLC41A1 located in the novel PD locus PARK16 has recently been identified as being a Na(+)/Mg(2+) exchanger (NME, Mg(2+) efflux system), a key component of cellular magnesium homeostasis. …”
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“…In general the introduction of an electron-donating group (e.g., Me, NMe(2)) at specific positions on the pyridine ring resulted in increased antiproliferative activity, whereas electron-withdrawing groups (e.g., COMe, COOMe, CONEt(2)) decreased anticancer activity. …”
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“…MetAPs catalyze N-terminal methionine excision (NME), an essential pathway of cotranslational protein maturation. …”
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“…Kinetic studies of the reactions of two previously characterized copper(iii)-hydroxide complexes (LCuOH and (NO(2))LCuOH, where L = N,N′-bis(2,6-diisopropylphenyl)-2,6-pyridine-dicarboxamide and (NO(2))L = N,N′-bis(2,6-diisopropyl-4-nitrophenyl)pyridine-2,6-dicarboxamide) with a series of para substituted phenols ((X)ArOH where X = NMe(2), OMe, Me, H, Cl, NO(2), or CF(3)) were performed using low temperature stopped-flow UV-vis spectroscopy. …”
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“…In order to probe the role of the amino moiety, we turned our attention to UiO-67, UiO-67-NMe(2) and UiO-67-NH(2). In these MOFs, the amino moiety is in close proximity to the zirconium node. …”
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“…Interactions with TUBB, TUBB2A, NME1 and SOD1 were also identified. The AIP variants p.R304* and p.R304Q showed impaired interactions with HSPA8, HSP90AB1, NME1 and SOD1; p.R304* also displayed reduced binding to TUBB and TUBB2A, and AIP-mutated tumors showed reduced TUBB2A expression. …”
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“…The peptide cyclo(FRGDLAFp(NMe)K) was decorated with different chelators (DOTPI, DOTAGA, and DOTA). …”
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