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Mostrando 21 - 40 Resultados de 647 Para Buscar '"NME"', tiempo de consulta: 0.18s Limitar resultados
  1. 21
    “…NME3 is a member of the nucleoside diphosphate kinase (NDPK) family that binds to the mitochondrial outer membrane to stimulate mitochondrial fusion. …”
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    NME3 Regulates Mitochondria to Reduce ROS-Mediated Genome Instability
  2. 22
    “…Elongated peroxisomes were observed in cells with suppressed expression of NME3 and fibroblasts from a patient lacking NME3 due to the homozygous mutation at the initiation codon of NME3. …”
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    Mammalian Homologue NME3 of DYNAMO1 Regulates Peroxisome Division
  3. 23
    “…As a complete lack of Nme7 is semilethal in rats, we compared morphometric, metabolic, and transcriptomic profiles of standard diet-fed heterozygous Nme7+/− on male rats vs. their wild-type Nme7+/+ controls. …”
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    Heterozygous Nme7 Mutation Affects Glucose Tolerance in Male Rats
  4. 24
    por Schlattner, Uwe
    Publicado 2021
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    The Complex Functions of the NME Family—A Matter of Location and Molecular Activity
  5. 25
    “…To identify affecting factors associated with frequency of accompanying NME on MR and positive pathologic result, clinicopathologic features were compared between breast cancers with NME and without NME, and between breast cancers with positive NME and negative NME using the Student t-test or Chi-square test. …”
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    The clinical significance of accompanying NME on preoperative MR imaging in breast cancer patients
  6. 26
    “…NME1 and NME2 have been shown to possess histidine (His) kinase activity. …”
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    The Potential Functional Roles of NME1 Histidine Kinase Activity in Neuroblastoma Pathogenesis
  7. 27
    “…NME7 (non-metastatic cells 7, nucleoside diphosphate kinase 7) is a member of a gene family with a profound effect on health/disease status. …”
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    Semi-Lethal Primary Ciliary Dyskinesia in Rats Lacking the Nme7 Gene
  8. 28
    “…The PA binding function and hexamerization confer NME3 mitochondrial tethering activity. Importantly, nutrient starvation enhances the enrichment efficiency of NME3 at the mitochondrial contact interface, and the tethering ability of NME3 contributes to fusion efficiency. …”
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    NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering
  9. 29
    “…NME2 could, therefore, severe as a risk marker for gastric cancer invasiveness and a potential new target for gene therapy to enhance or induce NME2 expression.…”
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    NME2 Reduces Proliferation, Migration and Invasion of Gastric Cancer Cells to Limit Metastasis
  10. 30
    “…Although most studies have focused on NME1, the NME1 gene also encodes the protein (NME1L) containing N-terminal 25 extra amino acids by alternative splicing. …”
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    Characterization of Functional Domains in NME1L Regulation of NF-κB Signaling
  11. 31
    “…The Awd (abnormal wing discs) gene is the Drosophila homolog of human NME1 and NME2 metastasis suppressor genes. These genes play a key role in tumor progression. …”
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    Vps28 Is Involved in the Intracellular Trafficking of Awd, the Drosophila Homolog of NME1/2
  12. 32
    “…Here, we report ethyl 3-benzoyl-2,7-dimethyl indolizine-1-carboxylate (INLZ) as a novel molecule with high energetic fitness scores at the catalytic site of the NmeNANAS enzyme. INLZ represents a promising scaffold for NmeNANAS enzyme inhibitors, with new prospects for further structural development and activity optimization.…”
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    Design, synthesis, and structural elucidation of novel NmeNANAS inhibitors for the treatment of meningococcal infection
  13. 33
    “…The Nme gene/protein family of nucleoside diphosphate kinases (NDPK) was originally named after its member Nm23-H1/Nme1, the first identified metastasis suppressor. …”
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    Characterization of Nme5-Like Gene/Protein from the Red Alga Chondrus Crispus
  14. 34
    “…Awd, the Drosophila homologue of NME1/2 metastasis suppressors, plays key roles in many signaling pathways. …”
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    The Impact of Drosophila Awd/NME1/2 Levels on Notch and Wg Signaling Pathways
  15. 35
    “…The metastasis suppressor protein NME1 is an evolutionarily conserved and multifunctional enzyme that plays an important role in suppressing the invasion and metastasis of tumour cells. …”
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    Regulation of metastasis suppressor NME1 by a key metabolic cofactor coenzyme A
  16. 36
    “…Here, we have engineered Nme2Cas9 to further increase the activity and targeting scope of compact Nme2Cas9 base editors. …”
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    Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope
  17. 37
    “…Recently, a large meta-analysis of five genome wide association studies (GWAS) has identified that a novel single nucleotide polymorphism (SNP) rs2718058, adjacent to gene NME8 on chromosome 7p14.1, was associated with late-onset Alzheimer's disease (LOAD) in Caucasians. …”
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    NME8 rs2718058 polymorphism with Alzheimer's disease risk: a replication and meta-analysis
  18. 38
    “…NME and STRAP mRNAs are expressed in developing and adult rodent midbrain. …”
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    STRAP and NME1 Mediate the Neurite Growth-Promoting Effects of the Neurotrophic Factor GDF5
  19. 39
    por Qi, Yaxin, Wei, Jun, Zhang, Xiaobo
    Publicado 2021
    “…In this investigation, it was found that transcription factor NME2 (NME/NM23 nucleoside diphosphate kinase 2) was upregulated in gastric cancer stem-like cells that sorted from the solid tumors of patients with gastric cancer and gastric cancer cell lines. …”
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    Requirement of transcription factor NME2 for the maintenance of the stemness of gastric cancer stem-like cells
  20. 40
    “…BACKGROUND: Mitochondrial nucleoside diphosphate kinase (NDPK-D, NME4, NM23-H4) is a multifunctional enzyme mainly localized in the intermembrane space, bound to the inner membrane. …”
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    The mitochondrially-localized nucleoside diphosphate kinase D (NME4) is a novel metastasis suppressor
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