“…We show pharmaceutical innovation has significantly increased over the last several decades despite recent concerns over an innovation crisis and find Pioneers (a NME whose shape and scaffold were not used in any previously FDA-approved drugs) are significantly more likely to be the source of promising new therapies. …”
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“…The design and synthesis of this new photocatalyst, [Ir(dF(CF(3))ppy)(2)(dNMe(3)bpy)]Cl(3), is presented. In contrast to commonly used iridium photocatalysts, this complex is highly water soluble and allows peptides and proteins to be modified in water and aqueous solvents under physiologically relevant conditions, with short reaction times and with low reagent and catalyst loadings. …”
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“…While complexes [Fe(PNP(NMe)‐iPr)(CO)(2)], [Fe(PNP(NEt)‐iPr)(CO)(2)] adopt a trigonal bipyramidal geometry, the bulkier and more electron rich [Fe(PNP(NH)‐tBu)(CO)(2)] is closer to a square pyramidal geometry. …”
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“…The monopotassium reagent reacts with one or half an equivalent of B(2)(NMe(2))(2)Cl(2) to afford NDP‐based diboranes with three or four amino substituents.…”
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“…[K(18‐crown‐6)][P(CF(3))(4)], [K(18‐crown‐6)][P(CF(3))(3)F], and [NMe(4)][P(CF(3))(2)F(2)] were obtained by treatment of trivalent precursors with sources of CF(3) (−) or F(−) units. …”
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“…Here, using a GFP-activation assay, we tested the activities of 29 type II-C orthologs closely related to Nme1Cas9, 25 of which are active in human cells. …”
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“…For a new molecular entity (NME) to become a drug, it is not only essential to have the right biological activity also be safe and efficient, but it is also required to have a favorable pharmacokinetic profile including toxicity (ADMET). …”
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“…Abbreviations: ACTB/β-actin: actin beta; Atg8: autophagy-related 8; CL: cardiolipin; CCCP: carbonyl cyanide m-chlorophenyl hydrazone; DMSO: dimethyl sulfoxide; DOPE: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine; DTT: DL-dithiothreitol; FKBP8: FKBP prolyl isomerase 8; GABARAP: GABA type A receptor associated protein; GABARAPL1: GABA type A receptor associated protein like 1; GABARAPL2: GABA type A receptor associated protein like 2; GFP: green fluorescent protein; IMM: inner mitochondrial membrane; LUV/LUVs: large unilamellar vesicle/s; MAP1LC3A/LC3A: microtubule associated protein 1 light chain 3 alpha; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAP1LC3C/LC3C: microtubule associated protein 1 light chain 3 gamma; NME4/NDPK-D/Nm23-H4: NME/NM23 nucleoside diphosphate kinase 4; O/A: oligomycin A + antimycin A; OMM: outer mitochondrial membrane; PA: phosphatidic acid; PC: phosphatidylcholine; PG: phosphatidylglycerol; PINK1: PTEN induced putative kinase 1; PtdIns4P: phosphatidylinositol-4-phosphate; Rho-PE: lissamine rhodamine phosphatidylethanolamine; SUV/SUVs: small unilamellar vesicle/s…”
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“…The significant advantages of DATs are the fluorescence of their powders (QY up to 98.7%). DAT-NMe(2) 10 expressed bright aggregation-induced emission (AIE) behavior in DMSO and THF as the water content increased. …”
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“…Non-negative Matrix Factorization (NME) is an algorithm that can reduce high dimensional datasets of tens of thousands of genes to a handful of metagenes which are biologically easier to interpret. …”
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“…Herein, we switch the position of the electron-donating NMe(2) group around the core of benzo[g]coumarins (BgCoum) and tune the electronic coupling and the charge-transfer character of the fluorescent excited states. …”
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“…The asymmetric unit contains three (NMe(4))(+) cations, one [Mo(2)S(8)Cu](3−) anion and one DMF solvent mol­ecule, and no obvious inter­actions are observed between these species. …”
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“…The title compound, [Li(2)(C(9)H(14)N)(C(16)H(36)P(3))](n), is a by-product of the reaction of [Cp(C(5)H(4)CH(2)CH(2)NMe(2))ZrCl(2)](n) with (t)Bu(2)P–P(SiMe(3))Li in toluene. …”
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“…This cyclic peptide was later modified by N-methylation of one peptide bond to yield an even greater antagonistic activity in c(RGDf(NMe)V). This peptide was then dubbed Cilengitide and is currently developed as drug by the company Merck-Serono (Germany). …”
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“…This is an essential step in the N-terminal Met excision (NME) that occurs in these proteins from eukaryotic mitochondria or chloroplasts. …”
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“…The title compound, [Al(2)K(2)(C(2)H(6)N)(8)(C(4)H(8)O)](n), formed during the sonochemical reaction between Al(NMe(2))(3) and sodium–potassium alloy in the presence of tetra­hydro­furan (THF). …”
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“…The stability of ketimines is an intermediate of those found for enolimines and enaminones i.e., (E)-2-(benzo[d]oxazol-2(3H)-ylidene)-1-phenylethanones. (13)C CPMAS NMR spectral data reveal that in the crystalline state the ketimine tautomer is predominant in p-NMe(2) substituted congener. On the other hand, enolimine forms were detected there when the substituent has less electron-donating character or when it is an electron-acceptor by character.…”
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“…In addition to APOE, recent large genome-wide association studies have identified variation in over 20 loci that contribute to disease risk: CR1, BIN1, INPP5D, MEF2C, TREM2, CD2AP, HLA-DRB1/HLA-DRB5, EPHA1, NME8, ZCWPW1, CLU, PTK2B, PICALM, SORL1, CELF1, MS4A4/MS4A6E, SLC24A4/RIN3,FERMT2, CD33, ABCA7, CASS4. …”
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