“…We show that Star-PAP and PIPKIα together regulate 3′-end processing and expression of pre-mRNAs encoding key anti-invasive factors (KISS1R, CDH1, NME1, CDH13, FEZ1, and WIF1) in breast cancer. Consistently, the endogenous Star-PAP level is negatively correlated with the cellular invasiveness of breast cancer cells. …”
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“…The mRNA expression of ARPC1B, ARPC3, TUBA8, TUBA1C, CTNNA2, ACTN3, MET, HGF, NME1 and ARF6, which are involved in the adherens junction pathway and in remodeling of adherens junctions, was analyzed using quantitative real-time polymerase chain reaction. …”
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“…This finding is supported by the computational results, which show that the rate-determining step drops from 24.6 kcal mol(–1) to 18.3 kcal mol(–1) when (p-NO(2)C(6)H(4))CH[double bond, length as m-dash]CH(2) is used and slightly increases to 25.5 kcal mol(–1) using (p-NMe(2)C(6)H(4))CH[double bond, length as m-dash]CH(2) as the substrate.…”
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“…Chemical Double Mutant Cycles (DMCs) were used to measure fifteen different aromatic stacking interactions as a function of substituent (NMe(2), OMe, Me, Cl and NO(2)). When both aromatic rings have electron-withdrawing nitro substituents, the interaction is attractive (–2.8 kJ mol(–1)) due to reduced π-electron repulsion. …”
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“…We investigated the tautomeric equilibrium resulting from protonation of Fe(P(Et)N(Me)P(Et))(CO)(3) (P(Et)N(Me)P(Et) = (Et(2)PCH(2))(2)NMe) at Fe or N. Protonation of Fe(P(Et)N(Me)P(Et))(CO)(3) by [(Et(2)O)(2)H](+)[B(C(6)F(5))(4)](–) occurs at the metal to give the iron hydride [Fe(P(Et)N(Me)P(Et))(CO)(3)H](+)[B(C(6)F(5))(4)](–). …”
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“…Among the catalysts used for the reduction of water to hydrogen, MoS(2) has been identified as one of the most promising materials as it can be engineered to provide not only a large surface area but also an abundance of unsaturated and reactive coordination sites. Using Mo[NMe(2)](4) and H(2)S as precursors, a desired thickness of amorphous MoS(2) can be deposited on TiO(2) nanotubes by atomic layer deposition. …”
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“…When the prepared complexes were reacted with anhydrous [(C(18)H(37))(2)N(H)Me](+)[B(C(6)F(5))(4)](−), desired ion-pair complexes, in which (C(18)H(37))(2)NMe coordinated to the Hf center, were cleanly afforded. …”
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“…Clinically, NAE resembles other necrolytic erythemas like necrolytic migratory erythema (NME), acrodermatitis enteropathica (AE) and pellagra. …”
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“…The results showed that 7 genes related to growth and metabolism, namely, ANPEP, ENPEP, UPP1, SLC2A2, SLC6A19, NME4, and LOC106034733, were significantly expressed in group H, which was consistent with the phenotype results. …”
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“…Alkali metal cations in solution had no effect on the IVCT bands of [(I(2)P(2−))(I(2)P(3−))Al](2−) complexes containing –PhNMe(2) or –PhF(5) substituents. Minor localization of charge in [(I(2)P(2−))(I(2)P(3−))Al](2−) was observed when –PhOMe substituents are included.…”
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“…One catalyst, two reaction set‐ups, three monomers and unlimited macromolecular microstructural designs: The iron guanidine complex [FeCl(2)(TMG5NMe(2)asme)] (1) polymerizes lactide faster than the industrially used Sn(Oct)(2) and shows high activity towards glycolide and ϵ‐caprolactone. …”
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“…More interestingly, NOTCH2 and NME1 could be potential targets for m6A regulation of AD. …”
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“…When the catalyst is modified by the addition of a chelating bisphosphine ligand (dppp), an organic base (Cy(2)NMe), sodium acetate, and aryl triflates are used as electrophiles, the α-arylation pathway is promoted preferentially. …”
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“…Also using SbI(3) and [H(2)NMe(2)](3)[SbI(6)], a compound featuring a single octahedral [SbI(6)](3−) unit, as limiting cases, we show that structure‐property relationships can be established in group 15 halogenido metalates in a similar way as in metal halide perovskites, thus providing a framework for understanding new and known compounds in this emerging class of materials.…”
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“…Two oxoiron(IV) isomers (( R ) 2a and ( R ) 2b) of general formula [Fe(IV)(O)((R)PyNMe(3))(CH(3)CN)](2+) are obtained by reaction of their iron(II) precursor with NBu(4)IO(4). …”
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“…Because of the analysis, the factors affecting the success of the clinical trials were varied according to each clinical phase and the drug types: New Molecular Entity (NME)/Biologics, and the success ratio in the quality variable affected the overall clinical trial phases. …”
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“…The iodine(I) complexes were synthesized from their analogous silver(I) complexes (2a–5a) via a silver(I) to iodine(I) cation exchange reaction, incorporating functionally related substituents as 3-acetaminopyridine in 1b; 3-acetylpyridine (3-Acpy; 2), 3-aminopyridine (3-NH(2)py; 3), and 3-dimethylaminopyridine (3-NMe(2)py; 4), as well as the strongly electron-withdrawing 3-cyanopyridine (3-CNpy; 5), to probe the possible limitations of iodine(I) complex formation. …”
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“…Estrogen regulation of other genes, including the anti-metastatic NME1 gene, is also altered. Overall, our results suggest that the balance coding/non-coding SRA transcripts not only characterizes particular tumor phenotypes but might also, through regulating the expression of specific genes, be involved in breast tumorigenesis and tumor progression.…”
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“…In the presence of strongly electron withdrawing (–CN) and strongly electron donating (–NMe(2)) substituents large Stokes shifts (up to 130 nm, 7828 cm(−1)) were observed in DMSO. …”
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“…In this study, we show that this domain within CDK5RAP2 associates with the γ-tubulin ring complex (γ-TuRC) to stimulate its microtubule-nucleating activity and is therefore referred to as the γ-TuRC–mediated nucleation activator (γ-TuNA). γ-TuNA but not its γ-TuC–binding-deficient mutant stimulates microtubule nucleation by purified γ-TuRC in vitro and induces extensive, γ-TuRC-dependent nucleation of microtubules in a microtubule regrowth assay. γ-TuRC bound to γ-TuNA contains NME7, FAM128A/B, and actin in addition to γ-tubulin and GCP2–6. …”
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