“…Validated hits include Ssa2 and mC21orf2 with ciliation defects; Ift46 with short cilia; Ptpdc1 and Iqub with elongated cilia; and Arl3, Nme7, and Ssna1 with distinct ciliary transport but not length defects. …”
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“…The spectra are consistent with sugars such as 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-L-manno-nonulosonic acid (Pse5Ac7Ac) previously described on flagellins, 5-acetamidino-7-acetamido-3,5,7,9-tetradeoxy-L-glycero-L-manno-nonulosonic acid (Pse5Am7Ac), bacillosamine derivatives and a potential legionaminic acid derivative (Leg5AmNMe7Ac) which were not previously identified in H. pylori. …”
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“…Similarly, a natural substrate of MMP-2, Ace-Gln-Gly ∼ Ile-Ala-Gly-Nme, can be converted to an inhibiting compound by two replacements, Ile by Cys and Gly by the d isomer of Cys, favoring formation of the zinc finger motif.…”
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“…Similarly, DDX26, ERCC5, FZD4, NME4, OPTN, and RB1 were both lost and under-expressed genes, and are thus putative TGCT suppressor genes. …”
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“…The other two bonds in this unit have double-bond character as have the four C—N bonds to the outer NMe(2) groups. In contrast, the three C—N bonds to the central N atom of the (di­methyl­aza­nium­yl)propyl group have single-bond character. …”
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“…The X‐ray crystal structures of two active complexes are reported, 1‐I (R(1)=OEt, R(2)=H) and 2‐I (R(1)=H, R(2)=NMe(2)). They were labelled with the radionuclide (131)I (β(−)/γ emitter, t(1/2) 8.02 d), and their activity in MCF‐7 human breast cancer cells was studied. 1‐[(131)I] and 2‐[(131)I] exhibit good stability in both phosphate‐buffered saline and blood serum. …”
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“…These complexes were prepared by a formal 1,4‐proton migration reaction when the metal triamides [M(N′′)(3)] were treated with the N‐heterocyclic olefin H(2)C=C(NMeCH)(2), which constitutes a new, general way to prepare MIC complexes. …”
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“…Specifically, we focused on seven classes of new molecular entity (NME) classified by the anatomic therapeutic chemical (ATC) classification system. …”
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“…The conformational propensities of the Aib residue on the example of two model peptides Ac-Aib-NHMe (1) and Ac-Aib-NMe(2) (2), were studied by B3LYP and M06-2X functionals, in the gas phase and in the polar solvents. …”
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“…A series of seven N-heterocyclic carbene–borane (NHC–borane) adducts ((R′CNR)(2)C)(HBC(8)H(14)) (R′ = H, R = dipp 4a, Mes 5a, Me 8a; R = Me R′ = Me 9a, Cl, 10a) and ((HC)(2)(NMe)(NR)C)(HBC(8)H(14)) (R = tBu, 6a, Ph 7a) are prepared and converted to corresponding borenium salts. …”
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“…Conversion of [U(BIPM(TMS))(Cl)(μ‐Cl)(2)Li(THF)(2)] (1, BIPM(TMS)=C(PPh(2)NSiMe(3))(2)) into [U(BIPM(TMS))(Cl){CH(Ph)(SiMe(3))}] (2), and addition of [Li{CH(SiMe(3))(PPh(2))}(THF)]/Me(2)NCH(2)CH(2)NMe(2) (TMEDA) gave [U{C(SiMe(3))(PPh(2))}(BIPM(TMS))(μ‐Cl)Li(TMEDA)(μ‐TMEDA)(0.5)](2) (3) by α‐hydrogen abstraction. …”
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“…We found that a selective µ-opioid agonist, [D-Ala(2), NMe-Phe(4), Gly-ol]-enkephanlin (DAMGO), induced an outward current mediated by K(+) channels in GABAergic interneurons. …”
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“…Reaction of [U{C(SiMe(3))(PPh(2))}(BIPM)(μ‐Cl)Li(TMEDA)(μ‐TMEDA)(0.5)](2) (BIPM=C(PPh(2)NSiMe(3))(2); TMEDA=Me(2)NCH(2)CH(2)NMe(2)) with [Rh(μ‐Cl)(COD)](2) (COD=cyclooctadiene) affords the heterotrimetallic U(IV)−Rh(I) (2) complex [U(Cl)(2){C(PPh(2)NSiMe(3))(PPh[C(6)H(4)]NSiMe(3))}{Rh(COD)}{Rh(CH(SiMe(3))(PPh(2))}]. …”
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“…cis- and trans-Isomers of the platinum(II) nitrile complexes [PtCl(2)(NCR)(2)] (R = NMe(2), N(C(5)H(10)), Ph, CH(2)Ph) were examined as catalysts for hydrosilylation cross-linking of vinyl-terminated polydimethylsiloxane and trimethylsilyl-terminated poly(dimethylsiloxane-co-ethylhydrosiloxane) producing high quality silicone rubbers. …”
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“…A series of diiron/tetrairon compounds containing a S- or a Se-function (2a–d, 4a–d, 5a–b, 6), and the monoiron [FeCp(CO){SeC(1)(NMe(2))C(2)HC(3)(Me)}] (3) were prepared from the diiron μ-vinyliminium precursors [Fe(2)Cp(2)(CO)( μ-CO){μ-η(1): η(3)-C(3)(R’)C(2)HC(1)N(Me)(R)}]CF(3)SO(3) (R = R’ = Me, 1a; R = 2,6-C(6)H(3)Me(2) = Xyl, R’ = Ph, 1b; R = Xyl, R’ = CH(2)OH, 1c), via treatment with S(8) or gray selenium. …”
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“…[Image: see text] The stability and the structure of adducts formed between four substituted phosphanes (PX(3), X:H, F, Cl, and NMe(2)) and 11 different carbenes have been investigated by DFT calculations. …”
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“…A computational model predicts our kinetic measurements and reveals the rate-limiting transition where laterally associated αβ-tubulins drive γ-TuRC into a closed conformation. NME7, TPX2, and the putative activation domain of CDK5RAP2 do not enhance γ-TuRC-mediated nucleation, while XMAP215 drastically increases the nucleation efficiency by strengthening the longitudinal γ-/αβ-tubulin interaction.…”
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“…Western blot analysis revealed that quercetin reduced copper-induced increase in p53 upregulated modulator of apoptosis (PUMA) expression and promoted upregulation of nucleoside diphosphate kinase NME1. Levels of p53 and Bax proteins were not affected by both copper and quercetin. …”
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“…By using the source modeling concept, the analytical predictive modeling and simulation of the AE were performed using normal mode expansion (NME). The simulation results showed good agreement with experimental results. …”
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“…The organo-osmium complex [Os(II)(ɳ(6)-p-cym)(PhAzPy-NMe(2))I](+) (FY26) exhibits promising in vitro antitumour activity against mouse hepatocarcinoma Hepa1–6 and other mouse or human cancer cell lines. …”
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