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581por Gardner, Benedict M., King, David M., Tuna, Floriana, Wooles, Ashley J., Chilton, Nicholas F., Liddle, Stephen T.“…Complex 2 is also formed by treatment of [U(Tren(TIPS)){OP(NMe(2))(3)}] (3) with Ph(3)PS, whereas treatment of 3 with elemental sulfur gives the diuranium(iv)-persulfido complex [{U(Tren(TIPS))}(2)(μ-η(2):η(2)-S(2))] (4). …”
Publicado 2017
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582por Cukier, HN, Kunkle, BK, Hamilton, KL, Rolati, S, Kohli, MA, Whitehead, PL, Jaworski, J, Vance, JM, Cuccaro, ML, Carney, RM, Gilbert, JR, Farrer, LA, Martin, ER, Beecham, GW, Haines, JL, Pericak-Vance, MA“…RESULTS: Rare variants were found in known AD risk genes including AKAP9, CD33, CR1, EPHA1, INPP5D, NME8, PSEN1, SORL1, TREM2 and UNC5C. Three families had five variants of interest in linkage regions with LOD>2. …”
Publicado 2017
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583“…A panel of 12 genes (e.g., HSP90β, ERG1, GPC3, TKT, ACLY, and NME1 for HCC; SPT2, T4S3, CNX43, TTD1, HBD01 for CC) were detected and partly described for the first time as potential discrimination markers. …”
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584por Zhao, Xing-Cheng, Yang, Shao-Hua, Yan, Yi-Quan, Zhang, Xin, Zhang, Lin, Jiao, Bo, Jiang, Shuai, Yu, Zhi-Bin“…We have also identified 8 important genes (NME4, PNPLA7, GGT5, PTGS2, IGF1R, NT5C2, ENTPD1 and PTEN), a number of gene ontology categories and biological pathways that may be associated with military pilot hypertension. …”
Publicado 2018
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585por Velazquez-Salinas, Lauro, Pauszek, Steven J., Stenfeldt, Carolina, O’Hearn, Emily S., Pacheco, Juan M., Borca, Manuel V., Verdugo-Rodriguez, Antonio, Arzt, Jonathan, Rodriguez, Luis L.“…In this study, we report the distinctive genomic and biological characteristics of an epidemic (NJ0612NME6) strain of VSV compared with an endemic (NJ0806VCB) strain. …”
Publicado 2018
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586por Charron, Yves, Willert, Jürgen, Lipkowitz, Bettina, Kusecek, Barica, Herrmann, Bernhard G., Bauer, Hermann“…Previously we have shown that the responder function is accomplished by a dominant negative form of sperm motility kinase (SMOK(TCR)), while the distorter functions are accomplished by the Rho G protein regulators TAGAP, FGD2 and NME3 proposed to function in two oppositely acting pathways. …”
Publicado 2019
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587por Martens, Arthur, Kreuzer, Marvin, Ripp, Alexander, Schneider, Marius, Himmel, Daniel, Scherer, Harald, Krossing, Ingo“…However, the addition of [NMe(4)]F, in order to release Me(3)SiF and form CBD, led to the unexpected deprotonation of the cation. …”
Publicado 2019
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588por Yu, Tianliang, Acharya, Aneesha, Mattheos, Nikos, Li, Simin, Ziebolz, Dirk, Schmalz, Gerhard, Haak, Rainer, Schmidt, Jana, Sun, Yu“…Three leader genes (PSMD10, SOS1, WASF3), eight cross-talk genes (PSMD10, PSMD6, EIF2S1, GSTP1, DNAJC3, SEC61A1, MAPT, and NME1), and one signaling pathway (IL-17 signaling) emerged as peri-implantitis and T2DM linkage mechanisms. …”
Publicado 2019
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589por Wang, Wang, Shen, Mengcheng, Fischer, Conrad, Basu, Ratnadeep, Hazra, Saugata, Couvineau, Pierre, Paul, Manish, Wang, Faqi, Toth, Sandra, Mix, Doran S., Poglitsch, Marko, Gerard, Norma P., Bouvier, Michel, Vederas, John C., Penninger, Josef M., Kassiri, Zamaneh, Oudit, Gavin Y.“…We designed and synthesized a potent APLN-17 analog, APLN-NMeLeu9-A2, that is resistant to NEP cleavage. This stable APLN analog ameliorated Ang II-mediated adverse aortic remodeling and AAA formation in an established model of AAA, high-fat diet (HFD) in Ldlr(−/−) mice. …”
Publicado 2019
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590por Dolebo, Asrat Tera, Khayatzadeh, Negar, Melesse, Aberra, Wragg, David, Rekik, Mourad, Haile, Aynalem, Rischkowsky, Barbara, Rothschild, Max F., Mwacharo, Joram M.“…The genes involved in male reproduction were FOXJ1 (sperm function and successful fertilization) and NME5 (spermatogenesis). We also observed genes such as PKD2L2, MAGED1 and KDM3B, which have been associated with diverse fertility traits in both sexes of other species. …”
Publicado 2019
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591por Kunitomi, Haruko, Kobayashi, Yusuke, Wu, Ren-Chin, Takeda, Takashi, Tominaga, Eiichiro, Banno, Kouji, Aoki, Daisuke“…Gene expression microarray analysis identified 8 genes correlated with tumor progression (LZTFL1, TAPT1, SEL1L, PAQR6, NME7, TMEM109, CCDC58, and ANKRD40) that were commonly influenced in HEC50B and SPAC-S by LAMC1 silencing. …”
Publicado 2019
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592por Batema, Guido D., Korstanje, Ties J., Guillena, Gabriela, Rodríguez, Gema, Lutz, Martin, van Klink, Gerard P. M., Gossage, Robert A., van Koten, Gerard“…Post-modification of a series of NCN-pincer platinum(II) complexes [PtX(NCN-R-4)] (NCN = [C(6)H(2)(CH(2)NMe(2))(2)-2,6](–), R = C(O)H, C(O)Me and C(O)Et), X = Cl(–) or Br(–)) at the para-position using the McMurry reaction was studied. …”
Publicado 2021
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593por Sant’Anna-Silva, Ana Carolina B., Perez-Valencia, Juan A., Sciacovelli, Marco, Lalou, Claude, Sarlak, Saharnaz, Tronci, Laura, Nikitopoulou, Efterpi, Meszaros, Andras T., Frezza, Christian, Rossignol, Rodrigue, Gnaiger, Erich, Klocker, Helmut“…Several enzymes linked to accumulated metabolites in the malignant cells were found upregulated in tumor tissue datasets, particularly NME1 and SHMT2 mRNA expression. High expression of the two genes was associated with shorter disease-free survival in prostate cancer cohorts. …”
Publicado 2021
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594“…The eight major genes including RPS18, RPL30, NME2, USP33, GAB2, RPS3A, RPS25, and CEP57 were found in the interacting network pathway. …”
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595por Caise, Alexa, Griffin, Liam P., Heilmann, Andreas, McManus, Caitilín, Campos, Jesús, Aldridge, Simon“…Trapping experiments reveal that a key structural component is the central two‐way Ge=Ge donor‐acceptor bond: reactions with IMe(4) and W(CO)(5)(NMe(3)) give the base‐ or acid‐stabilized digermynes (Ar(NiPr2)Ge(IMe(4)))(2) (4) and (Ar(NiPr2)Ge{W(CO)(5)})(2) (5), respectively. …”
Publicado 2021
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596Molecular Analysis of Prognosis and Immune Pathways of Pancreatic Cancer Based on TNF Family Members“…The risk score formula was composed of RHOD, UBE2C, KLHDC7b, MSLN, ADAM8, NME3, GNG2, and MCOLN3. GSE57495 and GSE62452 datasets verified that patients in the high-risk group had a worse prognosis than those in the low-risk group. …”
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597por Cesari, Cristiana, Funaioli, Tiziana, Berti, Beatrice, Femoni, Cristina, Iapalucci, Maria Carmela, Vivaldi, Federico Maria, Zacchini, Stefano“…[Image: see text] The molecular nanocluster [Ni(36–x)Pd(5+x)(CO)(46)](6–) (x = 0.41) (1(6–)) was obtained from the reaction of [NMe(3)(CH(2)Ph)](2)[Ni(6)(CO)(12)] with 0.8 molar equivalent of [Pd(CH(3)CN)(4)][BF(4)](2) in tetrahydrofuran (thf). …”
Publicado 2021
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598por Ma, Dennis, Hernandez, Grace A., Lefebvre, Austin E. Y. T., Alshetaiwi, Hamad, Blake, Kerrigan, Dave, Kushal R., Rauf, Maha, Williams, Justice W., Davis, Ryan T., Evans, Katrina T., Longworth, Aaron, Masoud, Madona Y. G., Lee, Regis, Edwards, Robert A., Digman, Michelle A., Kessenbrock, Kai, Lawson, Devon A.“…Finally, we demonstrate a new role for the metabolic enzyme NME1 in promoting breast cancer metastasis, providing proof-of-principle that our culture-transplant system can be used for authentic propagation and engineering of patient tumor cells for functional studies of metastasis.…”
Publicado 2021
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599“…Based on the BDDCS class to which a drug is assigned, it is possible to predict the role of metabolic enzymes and transporters on the drug disposition of a new molecular entity (NME) prior to its administration to animals or humans. …”
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600por Yan, Li, Hu, Chunyan, Ji, Yangyang, Zou, Lifen, Zhao, Yang, Zhu, Yi, Wang, Xiaoshen“…Nine of 52 SMPs (ABCC5, ATP1B3, CLEC11A, FLNA, FSTL3, MMP1, NME1, OAS3, and PHLDB2) were included in the nomogram to effectively and accurately predict the LSCC patients' survival. …”
Publicado 2022
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