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601por Timechko, Elena E., Yakimov, Alexey M., Paramonova, Anastasia I., Usoltseva, Anna A., Utyashev, Nikita P., Ivin, Nikita O., Utyasheva, Anna A., Yakunina, Albina V., Kalinin, Vladimir A., Dmitrenko, Diana V.“…Proteins that overlap across different tissue types and different studies have been highlighted: DPYSL, SYT1, STMN1, APOE, NME1, and others. The most common biological processes for them were the positive regulation of neurofibrillary tangle assembly, the regulation of amyloid fibril formation, lipoprotein catabolic process, the positive regulation of vesicle fusion, the positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, removal of superoxide radicals, axon extension, and the regulation of actin filament depolymerization. …”
Publicado 2023
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602por Kaur, Gurvinder, Helmer, Rebecca A., Martinez-Marin, Dalia, Sennoune, Souad R., Washburn, Rachel L., Martinez-Zaguilan, Raul, Dufour, Jannette M., Chilton, Beverly S.“…Perforin-delivered granzyme A (GzmA) activation of DNase, Nme1, showed damaged nuclear single-stranded DNA (γH2AX immunostaining). …”
Publicado 2023
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603por Wong, Jeffrey Y. K., Ekanayake, Arunika I., Kharchenko, Serhii, Kirberger, Steven E., Qiu, Ryan, Kelich, Payam, Sarkar, Susmita, Li, Jiaqian, Fernandez, Kleinberg X., Alvizo-Paez, Edgar R., Miao, Jiayuan, Kalhor-Monfared, Shiva, John, J. Dwyer, Kang, Hongsuk, Choi, Hwanho, Nuss, John M., Vederas, John C., Lin, Yu-Shan, Macauley, Matthew S., Vukovic, Lela, Pomerantz, William C. K., Derda, Ratmir“…More importantly, a conjugate of PFS-SICRFFCGG and peptide apelin-17 analogue (N(3)-PEG(6)-NMe17A2) showed retention in circulation similar to SA-21; in contrast, apelin-17 analogue was cleared from the circulation after 2 min. …”
Publicado 2023
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604por Hosseini, Shahrbanou, Brenig, Bertram, Winitchakorn, Sunattinee, Kanmanee, Chanidapha, Srinual, Orranee, Tapingkae, Wanaporn, Gatphayak, Kesinee“…However, genes involved in antioxidant defense (GSTO1), apoptosis process (DUSP8), and tumor suppressor (KIAA1324, FBXO47, NME6) were upregulated in mycotoxins-exposed animals, suggesting activation of the antioxidant defense in response to mycotoxicity. …”
Publicado 2023
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6052512. A Decade in Review: An Analysis of the Qualified Infectious Disease Product (QIDP) Designation“…METHODS: We analyzed the FDA Database entitled, “Compilation of CDER New Molecular Entity (NME) Drug and New Biologic Approvals” for antimicrobial therapies approved after 2012. …”
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606por Schott, Jonathan M., Crutch, Sebastian J., Carrasquillo, Minerva M., Uphill, James, Shakespeare, Tim J., Ryan, Natalie S., Yong, Keir X., Lehmann, Manja, Ertekin-Taner, Nilufer, Graff-Radford, Neill R., Boeve, Bradley F., Murray, Melissa E., Khan, Qurat ul Ain, Petersen, Ronald C., Dickson, Dennis W., Knopman, David S., Rabinovici, Gil D., Miller, Bruce L., González, Aida Suárez, Gil-Néciga, Eulogio, Snowden, Julie S., Harris, Jenny, Pickering-Brown, Stuart M., Louwersheimer, Eva, van der Flier, Wiesje M., Scheltens, Philip, Pijnenburg, Yolande A., Galasko, Douglas, Sarazin, Marie, Dubois, Bruno, Magnin, Eloi, Galimberti, Daniela, Scarpini, Elio, Cappa, Stefano F., Hodges, John R., Halliday, Glenda M., Bartley, Lauren, Carrillo, Maria C., Bras, Jose T., Hardy, John, Rossor, Martin N., Collinge, John, Fox, Nick C., Mead, Simon“…ORs at variants near INPP5D and NME8 did not overlap between PCA and typical AD. …”
Publicado 2016
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607Publicado 2017“…METHODS: Gene recombination technology was used to construct pLentis-CMV-NME1-IRES2-PURO lentiviral vectors using a nuclear localization signal sequence, and the recombinant plasmid was verified using restriction enzyme analysis and sequencing. …”
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608“…The formation of supramolecular assemblies between [Pt(bzimpy-Et){C[triple bond, length as m-dash]CC(6)H(4)(CH(2)NMe(3)-4)}]Cl(2) (1) and mPPE-Ala and the FRET properties of the ensemble have been revealed from the UV-vis absorption, steady-state emission and time-resolved emission decay studies. …”
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609por Amini, Hashem, Ban, Željka, Ferger, Matthias, Lorenzen, Sabine, Rauch, Florian, Friedrich, Alexandra, Crnolatac, Ivo, Kenđel, Adriana, Miljanić, Snežana, Piantanida, Ivo, Marder, Todd B.“…A bis‐triarylborane tetracation (4‐Ar(2)B‐3,5‐Me(2)C(6)H(2))‐C≡C−C≡C‐(3,5‐Me(2)C(6)H(2)‐4‐BAr(2) [Ar=(2,6‐Me(2)‐4‐NMe(3)‐C(6)H(2))(+)] (2(4+)) shows distinctly different behaviour in its fluorimetric response than that of our recently published bis‐triarylborane 5‐(4‐Ar(2)B‐3,5‐Me(2)C(6)H(2))‐2,2′‐(C(4)H(2)S)(2)–5′‐(3,5‐Me(2)C(6)H(2)‐4‐BAr(2)) (3(4+)). …”
Publicado 2020
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610por Pan, Guoqiang, Ma, Yuehan, Suo, Jian, Li, Wei, Zhang, Yang, Qin, Shanshan, Jiao, Yan, Zhang, Shaopeng, Li, Shuang, Kong, Yuan, Du, Yu, Gao, Shengnan, Wang, Daguang“…CONCLUSION: Through the statistical analysis of metabolomics, we found that TG (54:2), G3P, α-aminobutyric acid, α-CEHC, dodecanol, glutamyl alanine, 3-methylalanine, sulfite, CL (63:4), PE-NMe (40:5), TG (53:4), retinol, 3-hydroxysterol, tetradecanoic acid, MG (21:0/0:0/0:0), tridecanoic acid, myristate glycine and octacosanoic acid may be biomarkers for peritoneal metastasis of gastric cancer.…”
Publicado 2020
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611por Vicente, Ascensión, Bravo-González, Luis-Alberto, López-Romero, Ana, Muñoz, Clara Serna, Sánchez-Meca, Julio“…Anterior cranial base length (SN), posterior cranial base length (SBa), total cranial base length (BaN), effective length of the maxilla (CoA), sagittal relationship between subspinale and supramentale (ANB), anterior facial height (NMe), and posterior facial height (SGo) values were significantly lower in the DS population than among control subjects. …”
Publicado 2020
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612por Kaur, Parmish, Mai, Lukas, Muriqi, Arbresha, Zanders, David, Ghiyasi, Ramin, Safdar, Muhammad, Boysen, Nils, Winter, Manuela, Nolan, Michael, Karppinen, Maarit, Devi, Anjana“…The C‐substituents on the N‐C‐N backbone (Me, NMe(2), NEt(2), where Me=methyl, Et=ethyl) and the N‐substituents from symmetrical iso‐propyl (iPr) to asymmetrical tertiary‐butyl (tBu) and Et were systematically varied to study the influence of the substituents on the physicochemical properties of the resulting compounds. …”
Publicado 2021
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613“…The metastasis suppressor protein NM23-H1 (NME1), whose ability to suppress the metastasis activities of different tumors has been widely described and was previously reported to alter phosphatidylinositol signaling. …”
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614“…The other involves the estrogen receptor (ESR1), which induces PEBP1 through the kinase NME1. Our model was derived in the specific context of breast cancer, but the observed responses to drug treatments were consistent in other cell lines. …”
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615por Wu, Wenqi, Liu, Su, Tian, Linyan, Li, Cheng, Jiang, Yanan, Wang, Jinhuan, Lv, Yangyang, Guo, Jing, Xing, Donghui, Zhai, Yixin, Sun, Huimeng, Li, Yuhang, Zhang, Luying, He, Xiang, Luo, Kaiping, Zhan, Hongjie, Zhao, Zhigang“…Results: A risk score model based on fourteen candidate MAGs (CCDC78, CD300LG, CTAG2, DYNLL2, MAPKAPK2, MREG, NME8, PGK2, RALBP1, SIGLEC1, SLC1A1, SLC39A12, TMEM63A, and WRAP73) was established. …”
Publicado 2023
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616por Faggion, Sara, Boschi, Elena, Veroneze, Renata, Carnier, Paolo, Bonfatti, Valentina“…A total of 18 candidate genes previously associated with BT (MX1), reproduction traits (TCF21, NME5, PTGFR, KCNQ1, UMODL1), and fat metabolism (CTSD, SYT8, TNNI2, CD81, EGR1, GIPC2, MIGA1, NEGR1, CCSER1, MTMR2, LPL, ERFE) were identified in the post-GWAS analysis. …”
Publicado 2023
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617por Kim, Minji, Lee, Mi-Hee, Hong, Soo-Jong, Yu, Jinho, Cho, Joongbum, Suh, Dong In, Kim, Hyung Young, Kim, Hye-Young, Jung, Sungsu, Lee, Eun, Lee, Sooyoung, Jeong, Kyunguk, Shim, Jung Yeon, Kim, Jeong Hee, Chung, Hai Lee, Jang, Yoon Young, Kwon, Ji-Won, Seo, Ju-Hee, Kim, Ju Hee, Ahn, Ji Young, Song, Kun-Baek, Song, Kyu-Sang, Kim, So Yeon, Kim, Seon Young, Kil, Hong Ryang, Chung, Eun Hee“…Rare genotypes (RPGR, HYDIN, NME5) were found as well. Chest computed tomography revealed bronchiectasis in 33 out of 41 patients. …”
Publicado 2023
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618“…Reverse transcription-quantitative polymerase chain reaction was performed to detect the expression levels of specific genes, including microRNA (miR)-620, ATP-binding cassette sub-family B member 1 (ABCB1), ABCC10, cytidine monophosphate kinase, deoxycytidine monophosphate deaminase (DCTD), nucleoside diphosphate kinase 1 (NME1), ribonucleoside-diphosphate reductase large subunit (RRM1) and RRMB2. …”
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619“…The serum levels of four autoantibodies including anti-ATCAY, HIST1H3F, NME7 and PAIP2 IgG were significantly different among NC, MCI and/or AD groups. …”
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620por Alonso-González, Carolina, González-Abalde, Cristina, Menéndez-Menéndez, Javier, González-González, Alicia, Álvarez-García, Virginia, González-Cabeza, Alicia, Martínez-Campa, Carlos, Cos, Samuel“…Among them, melatonin elevated the levels of PTEN and NME1, and decreased the levels of SNAI2, ERBB2, AKT, SERPINE1, SFN, PLAU, ATM and N3RC1. …”
Publicado 2022
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