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641por Quigley, Neil Gerard, Steiger, Katja, Richter, Frauke, Weichert, Wilko, Hoberück, Sebastian, Kotzerke, Jörg, Notni, Johannes“…METHODS: Monomeric and trimeric conjugates of cyclo(GLRGDLp(NMe)K(pent-4-ynoic amide)) were synthesized by click chemistry (CuAAC), labeled with Ga-68, and evaluated in MeWo (human melanoma) xenografted SCID mice by means of PET and ex-vivo biodistribution. αvβ8-integrin expression in murine tissues was determined by β8-IHC. …”
Publicado 2020
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642por Seo, Jieun, Byun, Min Soo, Yi, Dahyun, Lee, Jun Ho, Jeon, So Yeon, Shin, Seong A., Kim, Yu Kyeong, Kang, Koung Mi, Sohn, Chul-Ho, Jung, Gijung, Park, Jong-Chan, Han, Sun-Ho, Byun, Jayoung, Mook-Jung, Inhee, Lee, Dong Young, Choi, Murim“…The association analysis for common variants (allele frequency (AF) > 0.05) yielded several novel loci associated with Aβ deposition (PIWIL1-rs10848087), AD-Cm (NME8-rs2722372 and PSEN2-rs75733498), AD-Ct (PSEN1-rs7523) and, Hv (CASS4-rs3746625). …”
Publicado 2020
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643por Mao, Hongmei, Wang, Wenjun, Shi, Lili, Chen, Chen, Han, Chao, Zhao, Jinpeng, Zhuo, Qin, Shen, Shi, Li, Yan, Huo, Junsheng“…The results of the metabolomics analysis showed that the glycerophospholipid metabolism pathway was closely related to calcium supplementation, and more DG (44:6 n3), LysoPC (22:2) and PE (P-34:3) and less Cer (d43:0) and PE-NMe2 (46:3) were produced. CONCLUSIONS: The results clearly indicated that calcium supplementation was beneficial for decreasing bone loss in OVX-LC rats. …”
Publicado 2021
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644por Quigley, Neil Gerard, Steiger, Katja, Hoberück, Sebastian, Czech, Norbert, Zierke, Maximilian Alexander, Kossatz, Susanne, Pretze, Marc, Richter, Frauke, Weichert, Wilko, Pox, Christian, Kotzerke, Jörg, Notni, Johannes“…METHODS: Ga-68-Trivehexin was synthesized by trimerization of the optimized αvβ6-integrin selective cyclic nonapeptide Tyr2 (sequence: c[YRGDLAYp(NMe)K]) on the TRAP chelator core, followed by automated labeling with Ga-68. …”
Publicado 2021
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645por Shahi, Rajendra Bahadur, De Brakeleer, Sylvia, Caljon, Ben, Pauwels, Ingrid, Bonduelle, Maryse, Joris, Sofie, Fontaine, Christel, Vanhoeij, Marian, Van Dooren, Sonia, Teugels, Erik, De Grève, Jacques“…These variants were found in genes associated with known or suspected BC predisposition (PALB2, BARD1, CHEK2, RAD51C and FANCA) or in predisposing genes linked to other cancer types but not well-studied in the context of familial BC (EXO1, RECQL4, CCNH, MUS81, TDP1, DCLRE1A, DCLRE1C, PDE11A and RINT1) and genes associated with different hereditary syndromes but not yet clearly associated with familial cancer syndromes (ABCC11, BBS10, CD96, CYP1A1, DHCR7, DNAH11, ESCO2, FLT4, HPS6, MYH8, NME8 and TTC8). Exome-wide, only a few genes appeared to be enriched for PDAVs in the familial BC patients compared to controls. …”
Publicado 2019
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646por Peixoto, Carolina, Lopes, Marta B., Martins, Marta, Casimiro, Sandra, Sobral, Daniel, Grosso, Ana Rita, Abreu, Catarina, Macedo, Daniela, Costa, Ana Lúcia, Pais, Helena, Alvim, Cecília, Mansinho, André, Filipe, Pedro, Costa, Pedro Marques da, Fernandes, Afonso, Borralho, Paula, Ferreira, Cristina, Malaquias, João, Quintela, António, Kaplan, Shannon, Golkaram, Mahdi, Salmans, Michael, Khan, Nafeesa, Vijayaraghavan, Raakhee, Zhang, Shile, Pawlowski, Traci, Godsey, Jim, So, Alex, Liu, Li, Costa, Luís, Vinga, Susana“…Some are known to be tumor suppressor genes (OPCML-IT2), to be related to resistance to cancer therapies (RAC1P3), or to be involved in several cancer processes such as genome stability (XRCC6P2), tumor growth and metastasis (MIR602) and regulation of gene transcription (NME2P2). We show that the classification of CRC patients based on pre-selected features by regularized logistic regression is a valuable alternative to using DEGs, significantly increasing the models’ predictive performance. …”
Publicado 2023
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647“…The results showed that there were quaternary amine groups in the material, and that the functionalization did not have any obvious effect on the chemical and crystal structures of MIL-101-NH(2). The prepared MIL-101-$NMe_{3}^{+}$-PVDF MMM was used as an adsorbent for DSPE to enrich the seven phenoxy acid herbicides in water. …”
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