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Mostrando 61 - 80 Resultados de 647 Para Buscar '"NME"', tiempo de consulta: 0.95s Limitar resultados
  1. 61
    “…In addition, by swapping the PAM-interacting domain of Nme2ABE8e-797 with that of SmuCas9 or introducing point mutations of eNme2-C in Nme2ABE8e-797, we created Nme2ABE8e-797(Smu) and Nme2ABE8e-797(−C), respectively, which exhibited robust activities at a wide range of sites with N4CN PAMs in human cells. …”
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    Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope
  2. 62
    “…CR was defined as meropenem-nonsusceptible (NS). Only NME were analyzed because no CLSI breakpoint exists for IMI/REL against Morganellaceae. …”
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    2152. Activity of Imipenem/Relebactam Against Carbapenem-Resistant Non-Morganellaceae Enterobacterales (NME) in the United States – SMART 2019-2021
  3. 63
    “…The metastasis-suppressor nme gene (also called nm23), first identified in murine melanoma cells, exists as two forms in human: nme1 and nme2. …”
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    Potential prognostic value in human breast cancer of cytosolic Nme1 protein detection using an original hen specific antibody.
  4. 64
    “…Here we showed that Piwi-Like RNA-Mediated Gene Silencing 2 (PIWIL2) can upregulate c-Myc via binding with NME/NM23 nucleoside diphosphate kinase 2 (NME2). …”
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    PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation
  5. 65
    “…Surprisingly, here we found occupancy of the metastasis suppressor non-metastatic 2 (NME2) within the hTERT core promoter in HT1080 fibrosarcoma cells and HCT116 colon cancer cells and NME2-mediated transcriptional repression of hTERT in these cells. …”
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    Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex–dependent fashion
  6. 66
    por Guo, Guangxiu, Dai, Sujuan, Chen, Qing
    Publicado 2020
    “…METHODS: linc00261 and NME1 expression levels were determined in breast cancer tissue and adjacent normal tissue using qRT-PCR. …”
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    Long Noncoding RNA LINC00261 Reduces Proliferation and Migration of Breast Cancer Cells via the NME1-EMT Pathway
  7. 67
    “…Some highly metastatic types of breast cancer show decreased intracellular levels of the tumor suppressor protein NME1, also known as nm23-H1 or nucleoside diphosphate kinase A (NDPK-A), which decreases cancer cell motility and metastasis. …”
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    Bacillus anthracis’ PA(63) Delivers the Tumor Metastasis Suppressor Protein NDPK-A/NME1 into Breast Cancer Cells
  8. 68
    “…This study aimed to understand whether the effect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modified by β-catenin overexpression and cisplatin-based adjuvant chemotherapy. …”
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    Negative Effect of Reduced NME1 Expression on Recurrence-Free Survival in Early Stage Non-Small Cell Lung Cancer
  9. 69
    “…We found that the effects of NME1 require the RORα/ROR2 receptors. Furthermore, increased NF-κB-dependent transcription was partially required for the neurite growth-promoting effects of NME1. …”
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    NME1 Protects Against Neurotoxin-, α-Synuclein- and LRRK2-Induced Neurite Degeneration in Cell Models of Parkinson’s Disease
  10. 70
    “…BACKGROUND: The Nme gene family is involved in multiple physiological and pathological processes such as cellular differentiation, development, metastatic dissemination, and cilia functions. …”
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    Nme Gene Family Evolutionary History Reveals Pre-Metazoan Origins and High Conservation between Humans and the Sea Anemone, Nematostella vectensis
  11. 71
    “…Mechanistically, miR-196 performed it's their function by inhibiting NME4 expression and further activating p-JNK, suppressing TIMP1, and augmenting MMP1/9. …”
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    OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway
  12. 72
    “…OBJECTIVE: There is a heated debate on whether the prognostic value of NME1 is favorable or unfavorable. Thus, we carried out a meta-analysis to evaluate the relationship between NME1 expression and the prognosis of patients with digestive system neoplasms. …”
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    Prognostic Value of NME1 (NM23-H1) in Patients with Digestive System Neoplasms: A Systematic Review and Meta-Analysis
  13. 73
    “…Nucleoside diphosphate kinase 4 (NME4) is abnormally expressed in a variety of cancer types. …”
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    NME4 may enhance non-small cell lung cancer progression by overcoming cell cycle arrest and promoting cellular proliferation
  14. 74
    “…[Image: see text] Three efficient and high-yielding procedures have been developed for the conversion of primary amides into nitriles, mediated by hitherto unexplored P(NMe(2))(3), PCl(3), or P(OPh)(3). The reactions were conducted under operationally simple and mild conditions and displayed broad substrate scope and good functional group tolerance.…”
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    Efficient New Protocols for Converting Primary Amides into Nitriles Initiated by P(NMe(2))(3), PCl(3), or P(OPh)(3)
  15. 75
    “…The restriction endonuclease Type II R.NmeDI from Neisseria meningitidis 2120 (serogroup C, ST-11 complex) was characterized. …”
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    The restriction endonuclease R.NmeDI from Neisseria meningitidis that recognizes a palindromic sequence and cuts the DNA on both sides of the recognition sequence
  16. 76
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    Correction: Nme Gene Family Evolutionary History Reveals Pre-Metazoan Origins and High Conservation between Humans and the Sea Anemone, Nematostella vectensis
  17. 77
    “…In comparison, NME1, a close homolog of NME2, did not bind to vinculin promoter nor regulate its expression. …”
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    Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin
  18. 78
    por Khan, Imran, Steeg, Patricia S.
    Publicado 2017
    “…The NM23/NME gene was identified as a metastasis suppressor. …”
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    The relationship of NM23 (NME) metastasis suppressor histidine phosphorylation to its nucleoside diphosphate kinase, histidine protein kinase and motility suppression activities
  19. 79
    “…However, the role of NME1 in virus-infected cells remains unknown. Here, we showed that NME1 suppresses viral replication in foot-and-mouth disease virus (FMDV)-infected cells. …”
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    Foot-and-mouth disease virus induces lysosomal degradation of NME1 to impair p53-regulated interferon-inducible antiviral genes expression
  20. 80
    por Böhme, Uwe, Herbig, Marcus
    Publicado 2023
    “…We synthesized a series of new antimony(III) compounds by reaction of Sb(OEt)(3) with organic ligands of the type E(CH(2)-CH(2)-OH)(2), with E = NH, NMe, O, S, Se, and Te. The synthesized compounds have the general composition [E(CH(2)-CH(2)-O)(2)]Sb(OEt). …”
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    New Complexes of Antimony(III) with Tridentate O,E,O-Ligands (E = O, S, Se, Te, NH, NMe) Derived from N-Methyldiethanolamine
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