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161por Tan, Yu, Mai, Hui, Huang, Zhiqing, Zhang, Li, Li, Chengwei, Wu, Songxin, Huang, Huang, Tang, Wen, Liu, Yongxi, Jiang, Kuiming“…BACKGROUND: Non-mass enhancement (NME) is a diagnostic dilemma and highly reliant on the experience of the radiologists. …”
Publicado 2021
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162por Jurković, Marta, Ferger, Matthias, Drašković, Isabela, Marder, Todd B., Piantanida, Ivo“…The innovative design of a triarylborane (TB)-dye with one NMe(2)-alkylated (propargylated) group and one NMe(2) group yielded a system that is both an NMe(2) π-donor and an inductive NMe(2)-alkyl cationic acceptor. …”
Publicado 2023
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163por McLellan, Ross, Kennedy, Alan R., Mulvey, Robert E., Orr, Samantha A., Robertson, Stuart D.“…Sodium and potassium dihydropyridine congeners produce similar high yields of [NMe(2)BH(2)](2) but require longer times. Switching the solvent to pyridine induces a remarkable change in the dehydrocoupling product ratio, with (NMe(2))(2)BH favoured over [NMe(2)BH(2)](2) (e.g., 94 %:2 % for 1tLi). …”
Publicado 2017
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164por Yang, Mengdi, Sun, Yi, Sun, Jing, Wang, Zhiyu, Zhou, Yiyi, Yao, Guangyu, Gu, Yifeng, Zhang, Huizhen, Zhao, Hui“…This is the first instance where the genes ENO1, RPLP2, NME1‐NME2 and CAPS1 were associated with disease severity and progression in LUAD patients with BM. …”
Publicado 2018
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165“…P accumulation in the ME exceeded the NME from different P regimes. The ME demonstrated higher root activity compared to the NME grown in various P sources. …”
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166por Yu, Tao, Wu, Rongrong, Yao, Lin, Wang, Kui, Wang, Guiliang, Fan, Zhen, Wu, Nianlong, Fang, Xinggen“…OBJECTIVE: We assessed the neuromechanical efficiency (NME), neuroventilatory efficiency (NVE), and diaphragmatic function effects between pressure support ventilation (PSV) and neutrally adjusted ventilatory assist (NAVA). …”
Publicado 2020
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167“…Cycloaddition also occurred in reactions of [L(X)GaSb](2) (X = NMe(2), OEt, Cl) with Me(3)Si(H)CN(2), yielding distibiranes [L(X)GaSb](2)C(H)SiMe(3) (X = NMe(2)11, OEt 12, Cl 13). …”
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168por Pósa, Vivien, Stefanelli, Alessia, Nunes, Julia H. Bormio, Hager, Sonja, Mathuber, Marlene, May, Nóra V., Berger, Walter, Keppler, Bernhard K., Kowol, Christian R., Enyedy, Éva A., Heffeter, Petra“…One of these derivatives (COTI-NMe(2)) was discovered as an interesting new drug candidate with improved anticancer activity and resistance profile. …”
Publicado 2022
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169“…Introduction/Background: Necrolytic migratory erythema (NME) is a specific cutaneous eruption associated with glucagonoma, an alpha-cell secreting pancreatic neuroendocrine tumor. …”
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170“…Susceptibility to IMI/REL was similar in the US (99.8% of NME [n=846]; 93.8% of P. aeruginosa [n=96]) and Canada (99.7% of NME [n=339]; 96.4% of P. aeruginosa [n=28]). …”
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171“…The extracted PLs using CyNMe2 were recovered by bubbling CO(2) at atmospheric pressure, switching the CyNMe2 into its respective salt. …”
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172“…[Image: see text] A series of stilbene derivatives have been constructed by modifying the stilbene systems with different H, CN, NH(2), NMe(2), and NO(2) groups. In a vacuum, it was found that a redshift in the ultraviolet–visible spectrum occurred because of the enhancement of the donor/acceptor capabilities of this group, with the order of redshift being NO(2) > NMe(2) > CN > NH(2) > H. …”
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173por Alvarez, Alva Lucia, Maisonet, Irma O., Ruiz, Omar, Lumsden, Rebecca S., Ferreira, Ana Paula Evangelista, Avila Flores, Esther M.“…The core dossier approach was also evaluated against the standard submission of a similar small molecule, NME2. In contrast to the core dossier submission of NME1, a second round of questions, and high-complexity questions were received from two markets for NME2. …”
Publicado 2023
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174“…The hub DEGs (TSPO, PPIB, NME1 and NME2) were extracted in this subnetwork. …”
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175“…The abnormal wing discs (awd) gene encodes the Drosophila homolog of NME1/NME2 metastasis suppressor genes. Awd acts in multiple tissues where its function is critical in establishing and maintaining epithelial integrity. …”
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176por Thavalingam, Annoj, Cheng, Zhi, Garcia, Bianca, Huang, Xue, Shah, Megha, Sun, Wei, Wang, Min, Harrington, Lucas, Hwang, Sungwon, Hidalgo-Reyes, Yurima, Sontheimer, Erik J., Doudna, Jennifer, Davidson, Alan R., Moraes, Trevor F., Wang, Yanli, Maxwell, Karen L.“…Here, we report the crystal structures of anti-CRISPR protein AcrIIC2(Nme) alone and in complex with Nme1Cas9. We demonstrate that AcrIIC2(Nme) inhibits Cas9 through interactions with the positively charged bridge helix, thereby preventing sgRNA loading. …”
Publicado 2019
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177por Hoffmann, Mareike D, Mathony, Jan, Upmeier zu Belzen, Julius, Harteveld, Zander, Aschenbrenner, Sabine, Stengl, Christina, Grimm, Dirk, Correia, Bruno E, Eils, Roland, Niopek, Dominik“…Here, we report the first optogenetic tool to control NmeCas9 activity in mammalian cells via an engineered, light-dependent anti-CRISPR (Acr) protein. …”
Publicado 2020
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178“…The largest NME was for cleft-side cphi. The smallest NME value was for cleft-side alare. …”
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179por Seib, Kate L., Jen, Freda E.-C., Tan, Aimee, Scott, Adeana L., Kumar, Ritesh, Power, Peter M., Chen, Li-Tzu, Wu, Hsing-Ju, Wang, Andrew H.-J., Hill, Dorothea M. C., Luyten, Yvette A., Morgan, Richard D., Roberts, Richard J., Maiden, Martin C. J., Boitano, Matthew, Clark, Tyson A., Korlach, Jonas, Rao, Desirazu N., Jennings, Michael P.“…Single molecule, real-time (SMRT) methylome analysis was used to identify the recognition site for three key N. meningitidis methyltransferases: ModA11 (exemplified by M.NmeMC58I) (5′-CGY(m6)AG-3′), ModA12 (exemplified by M.Nme77I, M.Nme18I and M.Nme579II) (5′-AC(m6)ACC-3′) and ModD1 (exemplified by M.Nme579I) (5′-CC(m6)AGC-3′). …”
Publicado 2015
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180“…Neuromuscular exercise (NME) effectively improved pain and the range of motion in shoulder. …”
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