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  1. 1
    “…Therefore, we produced nanobodies (NBs) named NB-hNME1 that bind to hNME1 specifically, and the inhibitory effect of NB-hNME1 was evaluated for blocking the binding between hNME1 and pST8SIA1. …”
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    The Potential Role of Human NME1 in Neuronal Differentiation of Porcine Mesenchymal Stem Cells: Application of NB-hNME1 as a Human NME1 Suppressor
  2. 2
    “…Nucleoside diphosphate kinases (NDPK/NME/Nm23) are enzymes composed of subunits NME1/NDPK A and NME2/NDPK B, responsible for the maintenance of the cellular (d)NTP pool and involved in other cellular processes, such as metastasis suppression and DNA damage repair. …”
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    The Subcellular Localization and Oligomerization Preferences of NME1/NME2 upon Radiation-Induced DNA Damage
  3. 3
    “…Our aim was to understand how vesicular NME1 and NME2 released by breast cancer cells influence the tumour microenvironment. …”
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    Extracellular Vesicle-Mediated Metastasis Suppressors NME1 and NME2 Modify Lipid Metabolism in Fibroblasts
  4. 4
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    Targeting altered Nme heterooligomerization in disease?
  5. 5
    “…Class switch recombination (CSR) in B cells involves deletion‐recombination at switch (S) region DNA and is important for the diversification of antibody isotypes during an immune response. Here, we identify two NME [NM23/NDPK (nucleoside diphosphate kinase)] isoforms, NME1 and NME2, as novel players in this process. …”
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    NME proteins regulate class switch recombination
  6. 6
    “…The NME (Non-metastatic) family members, also known as NDPKs (nucleoside diphosphate kinases), were originally identified and studied for their nucleoside diphosphate kinase activities. …”
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    NME/NM23/NDPK and Histidine Phosphorylation
  7. 7
    “…[Image: see text] [Rh(κ(2)-PP-DPEphos){η(2)η(2)-H(2)B(NMe(3))(CH(2))(2)(t)Bu}][BAr(F)(4)] acts as an effective precatalyst for the dehydropolymerization of H(3)B·NMeH(2) to form N-methylpolyaminoborane (H(2)BNMeH)(n). …”
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    Dehydropolymerization of H(3)B·NMeH(2) Using a [Rh(DPEphos)](+) Catalyst: The Promoting Effect of NMeH(2)
  8. 8
    “…Metastatic activity was strongly enhanced in both genders of Nme1- and Nme2-null mice, with stronger activity in females across all genotypes. …”
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    Nme1 and Nme2 genes exert metastasis-suppressor activities in a genetically engineered mouse model of UV-induced melanoma
  9. 9
    “…BACKGROUND: NME6 is a member of the nucleoside diphosphate kinase (NDPK/NME/Nm23) family which has key roles in nucleotide homeostasis, signal transduction, membrane remodeling and metastasis suppression. …”
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    NME6 is a phosphotransfer-inactive, monomeric NME/NDPK family member and functions in complexes at the interface of mitochondrial inner membrane and matrix
  10. 10
    por Wanrooij, Paulina H, Chabes, Andrei
    Publicado 2023
    “…These data also suggest a significant physiological role for NME6, as its absence results in the depletion of mitochondrial transcripts and destabilization of the electron transport chain (Grotehans et al, 2023).…”
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    NME6: ribonucleotide salvage sustains mitochondrial transcription
  11. 11
    “…Although it is well accepted that the nucleoside diphosphate kinase NME1 is a metastasis suppressor, its effect on EMT remains poorly documented, as does that of its closely related isoform, NME2. …”
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    Loss of the Metastasis Suppressor NME1, But Not of Its Highly Related Isoform NME2, Induces a Hybrid Epithelial–Mesenchymal State in Cancer Cells
  12. 12
    “…Here we report that these tumors become highly metastatic following hemizygous deletion of the Nme1 and Nme2 metastasis suppressor genes (HPN mice). …”
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    Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients
  13. 13
    Publicado 2001
    Libro
    Programa desarrollo de competencias académicas hacia el NME.
  14. 14
    “…Here, we report that a mitochondrial nucleoside diphosphate kinase, NME6, supplies mitochondria with pyrimidine ribonucleotides that are necessary for the transcription of mitochondrial genes. …”
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    Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression
  15. 15
    “…Nme1, Nme2, Nme3, and Nme4 belong to Group I while vertebrate Nme5, Nme6, Nme7, Nme8, and Nme9 belong to Group II. …”
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    Nme protein family evolutionary history, a vertebrate perspective
  16. 16
    por Kar, Anirban, Chowdhury, Shantanu
    Publicado 2014
    “…Though anti-metastatic function of non-metastatic 2 (NME2) has been implicated in multiple cancers, mechanisms of metastases control by NME2 are not clearly understood. …”
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    Inhibition of telomerase activity by NME2: impact on metastasis suppression?
  17. 17
    “…Additionally, high NME 1 and NME2 levels were related to poor overall survival (OS), while the upregulated expression of NME3, NME5, and NME7 indicated prolonged survival. …”
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    Comprehensive analysis of the NME gene family functions in breast cancer
  18. 18
    “…Recently, isolated γTuRC was found to contain NME7, a poorly characterized member of the NME family. …”
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    NME7 is a functional component of the γ-tubulin ring complex
  19. 19
    “…We also validate at least six variant protospacer adjacent motifs (PAMs), in addition to the preferred consensus PAM (5′-N(4)GATT-3′), for NmeCas9 genome editing in human cells. CONCLUSIONS: Our results show that NmeCas9 is a naturally high-fidelity genome-editing enzyme and suggest that additional Cas9 orthologs may prove to exhibit similarly high accuracy, even without extensive engineering. …”
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    NmeCas9 is an intrinsically high-fidelity genome-editing platform
  20. 20
    “…Nme5(-/-) knockout mice exhibit doming of the skull, hydrocephalus and sperm flagellar defects. …”
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    NME5 frameshift variant in Alaskan Malamutes with primary ciliary dyskinesia
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