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121“…Acromesomelic dysplasia, type Maroteaux is caused by variants in NPR2. It is a severe chondrodysplasia resulting in shortening of the middle and distal segments of the limbs. …”
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122por Tamura, Yasuaki, Ito, Akira, Wakamatsu, Kazumasa, Kamiya, Takafumi, Torigoe, Toshihiko, Honda, Hiroyuki, Yamashita, Toshiharu, Uhara, Hisashi, Ito, Shosuke, Jimbow, Kowichi“…In our approach, NPrCAP provides a unique drug delivery system (DDS) because of its selective incorporation into melanoma cells. …”
Publicado 2022
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123“…We propose that Npr3 acts as a clearance receptor to regulate local concentrations of natriuretic peptides for optimal cGMP production through Npr1 activation, and as a signaling receptor to control cAMP levels through inhibition of adenylyl cyclase. …”
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124por Huang, Yao-Meng, Li, Tong-Xin, Li, Shu-Yu, Zhu, Xiao-Ran, Li, Ying, Liu, Dang-Yang, Li, Wei-Min, Yang, Lin-Quan, Liu, Kun-Shen, Liu, Chao“…In the present study, microinjection of CRISPR associated protein 9/single guide RNA into fertilized C57BL/6N mouse eggs was performed to generate filial generation zero (F0) Npr1 knockout homozygous mice (Npr1(-/-)). F0 mice mated with wild-type (WT) mice to obtain F1 Npr1 knockout heterozygous mice with stable heredity (Npr1(+/-)). …”
Publicado 2023
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125“…We found that loss-of-function mutations in npr-15 activated immunity while suppressing pathogen avoidance behavior. …”
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126“…Transgenic plants expressing AtNPR1 constitutively exhibited resistance against pathogens as well as herbivory. …”
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127por Jimbow, Kowichi, Ishii-Osai, Yasue, Ito, Shosuke, Tamura, Yasuaki, Ito, Akira, Yoneta, Akihiro, Kamiya, Takafumi, Yamashita, Toshiharu, Honda, Hiroyuki, Wakamatsu, Kazumasa, Murase, Katsutoshi, Nohara, Satoshi, Nakayama, Eiichi, Hasegawa, Takeo, Yamamoto, Itsuo, Kobayashi, Takeshi“…During these therapeutic processes, NPrCAP was also expected to provide melanoma-targeted drug delivery system.…”
Publicado 2013
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128por Sogawa, Chizuru, Fujiwara, Yasuhiro, Tsukamoto, Satoshi, Ishida, Yuka, Yoshii, Yukie, Furukawa, Takako, Kunieda, Tetsuo, Saga, Tsuneo“…To determine the role of CNP/NPR-B signaling in male reproduction we investigated phenotype of Npr2-deficient short-limbed-dwarfism (Npr2( slw/slw )) mice, which have been shown to have gastrointestinal (GI) abnormalities. …”
Publicado 2014
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129por Boeckstaens, Mélanie, Merhi, Ahmad, Llinares, Elisa, Van Vooren, Pascale, Springael, Jean-Yves, Wintjens, René, Marini, Anna Maria“…Upon preferred nitrogen supplementation, like glutamine or ammonium addition, TORC1 upregulation enables Npr1 inhibition and Amu1/Par32 dephosphorylation. …”
Publicado 2015
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131por Zhao, Xin-Ying, Wang, Jia-Gang, Song, Shi-Jian, Wang, Qun, Kang, Hui, Zhang, Yan, Li, Sha“…Introducing the SA deficient mutants, npr1-5 and NahG, but not other hormonal mutants, completely suppressed the precocious leaf senescence of PAT14 loss-of-function, further supporting the epistatic relation between PAT14 and the SA pathway. …”
Publicado 2016
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132por Nakad, Rania, Snoek, L. Basten, Yang, Wentao, Ellendt, Sunna, Schneider, Franziska, Mohr, Timm G., Rösingh, Lone, Masche, Anna C., Rosenstiel, Philip C., Dierking, Katja, Kammenga, Jan E., Schulenburg, Hinrich“…Subsequent transcriptional profiling of C. elegans wildtype and npr-1 mutant suggested that npr-1 mediates defense against both pathogens through p38 MAPK signaling, insulin-like signaling, and C-type lectins. …”
Publicado 2016
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133por Hu, Qin, Liu, Qiji, Wang, Shasha, Zhen, Xi, Zhang, Zhimian, Lv, Ruijuan, Jiang, Guihua, Ma, Zhiyong, He, Hong, Li, Daqing, Liu, Xiaoling, Gao, Fei, Li, Jifu, Li, Li, Zhang, Mei, Ji, Xiaoping, Chen, Yuguo, Wang, Daowen, Huang, Dejia, Ma, Aiqun, Huang, Wei, Zhao, Yuxia, Gong, Yaoqin, Zhang, Cheng, Zhang, Yun“…A novel locus rs700926 in natriuretic peptide receptor C (NPR-C) was identified in Shandong and Hubei cohorts. …”
Publicado 2016
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134por Ding, Meiling, Zhang, Bin, Zhang, Shuo, Hao, RongRong, Xia, Yu, Ma, Pengda, Dong, Juane“…Here, we report an NPR protein, SmNPR4, that showed strong expression in hairy root after SA treatment, acting as a negative moderator of SA-induced phenolic acid biosynthesis in S. miltiorrhiza (S. miltiorrhiza). …”
Publicado 2023
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135por Pernomian, Laena, Prado, Alejandro F., Silva, Bruno R., Azevedo, Aline, Pinheiro, Lucas C., Tanus-Santos, José E., Bendhack, Lusiane M.Enlace del recurso
Publicado 2016
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136por Gao, Jing, Bi, Weishuai, Li, Huanpeng, Wu, Jiaojiao, Yu, Xiumei, Liu, Daqun, Wang, Xiaodong“…In our subsequent analysis, barley transgenic line overexpressing wheat wNPR1 (wNPR1-OE) showed enhanced resistance to Magnaporthe oryzae isolate Guy11, whereas AR to Guy11 was suppressed in a barley transgenic line with knocked-down barley HvNPR1 (HvNPR1-Kd). …”
Publicado 2018
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137por Arise, Kiran K., Kumar, Prerna, Garg, Renu, Samivel, Ramachandran, Zhao, Hanqing, Pandya, Krishna, Nguyen, Christian, Lindsey, Sarah, Pandey, Kailash N.“…The transcription factors, cAMP-response element-binding protein (CREB) and heat-shock factor-4a (HSF-4a) facilitated the ANG II-mediated repressive effects on Npr1 transcription. Tyrosine kinase (TK) inhibitor, genistein and phosphatidylinositol 3-kinase (PI-3K) inhibitor, wortmannin reversed the ANG II-dependent repression of Npr1 transcription and receptor function. …”
Publicado 2020
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138por Wang, Yanchun, Jiang, Na, Wang, Bowen, Tao, Haoxia, Zhang, Xin, Guan, Qing, Liu, Chunjie“…NprR is a protein of Bacillus anthracis that exhibits moonlighting functions as either a phosphatase or a neutral protease regulator that belongs to the RNPP family. …”
Publicado 2020
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139por Xue, Xiaojing, Geng, Tiantian, Liu, Haifeng, Yang, Wei, Zhong, Weiran, Zhang, Zhiliang, Zhu, Changxiang, Chu, Zhaohui“…The Si-mediated accumulation of JA/JA-Ile was significantly attenuated in StETR1-, StEIN2-, StOPR3- and StHSP90-VIGS plants but not in StCOI1-, StSID2- and StNPR1-VIGS plants. Overall, we reveal that Si can be used as a putative alternative to fungicides to control LB, and conclude that Si-mediated LB resistance is dependent on the ET/JA-signaling pathways in a StHSP90- and StNPR1-dependent manner.…”
Publicado 2021
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140por Dai, Xing, Wang, Yankai, Yu, Kaili, Zhao, Yonghui, Xiong, Langyu, Wang, Ruozhong, Li, Shengben“…Overexpression of OsNPR1 significantly increases rice resistance to Xoo. …”
Publicado 2023
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