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  1. 261
    “…Construction in CN3718 of single nanI, nanJ and nanH null mutants, as well as a nanI/nanJ double null mutant and a triple sialidase null mutant, identified NanI as the major secreted sialidase of this strain. …”
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    Sialidases Affect the Host Cell Adherence and Epsilon Toxin-Induced Cytotoxicity of Clostridium perfringens Type D Strain CN3718
  2. 262
    “…RESULTS: The cluster of genes encoding the enzymes N-acetylneuraminate lyase (NanA), epimerase (NanE), and kinase (NanK), necessary for the catabolism of sialic acid (the Nan cluster), are confined 46 bacterial species, 42 of which colonize mammals, 33 as pathogens and 9 as gut commensals. …”
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    Insights into the evolution of sialic acid catabolism among bacteria
  3. 263
    “…Here, we report Pm-NanK:unliganded, Pm-NanK:AMPPNP, Pm-NanK:ManNAc, Hi-NanK:ManNAc, and Hi-NanK:ManNAc-6P:ADP crystal structures. …”
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    Structure and Function of N-Acetylmannosamine Kinases from Pathogenic Bacteria
  4. 264
    “…To verify this hypothesis, NanA and NanB were expressed in E. coli. After confirming their activity in enzyme assays, in vitro models with influenza virus A/Jena/8178/09 (Jena/8178) and the recombinant NanA or NanB (rNanA and rNanB) were established in A549 and MDCK cells to mimic the role of these pneumococcal NAs during co-infection. …”
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    Dual Acting Neuraminidase Inhibitors Open New Opportunities to Disrupt the Lethal Synergism between Streptococcus pneumoniae and Influenza Virus
  5. 265
    “…More specifically, regarding the number of NANs, we derive the optimal closed-form expression, i.e., the closed-form expression that assures the deployment of the maximum number of NANs in the considered region satisfying a given collision constraint on the transmissions of the NANs. …”
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    On the Probabilistic Deployment of Smart Grid Networks in TV White Space
  6. 266
    “…Neuraminidase A (NanA) is an important virulence factor that is anchored to the pneumococcal cell wall and cleaves sialic acid on host substrates. …”
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    Pneumococcal neuraminidase activates TGF-β signalling
  7. 267
    “…Biallelic genetic variants in N-acetylneuraminic acid synthase (NANS), a critical enzyme in endogenous sialic acid biosynthesis, are clinically associated with neurodevelopmental disorders. …”
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    Neurodevelopmental defects in human cortical organoids with N-acetylneuraminic acid synthase mutation
  8. 268
    “…Transcriptional analysis demonstrated expression of nanA depends on the enzymatic function of NanB. …”
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    Neuraminidase B controls neuraminidase A-dependent mucus production and evasion
  9. 269
    “…Remaining groups were given graded doses of AlCl(3) and/or NaN(3), as LD-AlCl(3) (AlCl(3) 40 mg), MD-AlCl(3) (AlCl(3) 45 mg), and HD-AlCl(3) (AlCl(3) 50 mg) representing low dose, medium dose, and high dose of AlCl(3), respectively, and the remaining as LD-NaN(3) (NaN(3) 13 mg), MD-NaN(3) (NaN(3) 15 mg), and HD-NaN(3) (NaN(3) 17 mg) representing low dose, medium dose, and high dose of NaN(3), respectively. …”
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    Comparative Biochemical Profiling of Aluminum Chloride and Sodium Azide Induced Neuroinflammation and Cardiometabolic Disturbance
  10. 270
    “…This Gram-positive anaerobic bacterium can produce up to three sialidases named NanH, NanI, and NanJ. The role of sialidases in histotoxic infections, such as gas gangrene (clostridial myonecrosis), remains equivocal. …”
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    Clostridium perfringens Sialidases: Potential Contributors to Intestinal Pathogenesis and Therapeutic Targets
  11. 271
    por Mukherjee, Kaustav, Bieker, James J.
    Publicado 2022
    “…First, we show that Nan-EKLF limits normal EKLF binding to a subset of its sites. …”
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    EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release
  12. 272
    “…BACKGROUND: In NANS deficiency, biallelic mutations in the N-acetylneuraminic acid synthase (NANS) gene impair the endogenous synthesis of sialic acid (N-acetylneuraminic acid) leading to accumulation of the precursor, N-acetyl mannosamine (ManNAc), and to a multisystemic disorder with intellectual disability. …”
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    The fate of orally administered sialic acid: First insights from patients with N-acetylneuraminic acid synthase deficiency and control subjects
  13. 273
    “…N-Acetyl-d-neuraminic acid lyase (NanA) catalyzes the breakdown of sialic acid (Neu5Ac) to N-acetyl-d-mannosamine (ManNAc) and pyruvate. …”
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    Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum
  14. 274
    “…The percentage of total NAN with respect to the total polyphenol content (TPC) values was calculated for each sample and established into three categories: high percentage NAN varieties (NANV), those varieties showing low percentages of NAN (ANV), and finally those varieties showing medium percentages of NAN (NANAV). …”
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    Non-Anthocyanin Compounds in Minority Red Grapevine Varieties Traditionally Cultivated in Galicia (Northwest Iberian Peninsula), Analysis of Flavanols, Flavonols, and Phenolic Acids
  15. 275
    “…In the present study, it was observed that cell viability decreased in a concentration-dependent manner 12 h after NaN(3) treatment (20, 30 and 50 mmol/l). A decrease in cell viability (to 51±3%) was observed 12 h after treatment with 30 mM NaN(3). …”
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    Neuroprotective effects of hydrogen sulfide on sodium azide-induced oxidative stress in PC12 cells
  16. 276
    “…Injecting dsRNA of Nan and Iav into fourth-instar nymphs significantly knocked down the target genes. …”
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    Knockdown of TRPV Genes Affects the Locomotion and Feeding Behavior of Nilaparvata lugens (Hemiptera: Delphacidae)
  17. 277
    “…BACKGROUNDS: Streptococcus pneumoniae expresses three distinct sialidases, NanA, NanB, and NanC, that are believed to be key virulence factors and thus, potential important drug targets. …”
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    Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases
  18. 278
    “…GBS possesses a protein with homology to the pneumococcal virulence factor, NanA, which has neuraminidase (sialidase) activity and promotes blood-brain barrier penetration. …”
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    Evolutionary inactivation of a sialidase in group B Streptococcus
  19. 279
    “…Sodium azide (NaN(3)) is a chemical of rapidly growing commercial importance. …”
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    Neuroprotective effects of hydrogen sulfide on sodium azide-induced autophagic cell death in PC12 cells
  20. 280
    “…However, NanM is localized in the periplasmic space and cannot facilitate Neu5Ac metabolism by NanA in the cytoplasm in vivo. …”
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    The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate
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