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74581“…These retrocopies demonstrated the potential to encode proteins or short peptides, act as cis- and trans- Natural Antisense Transcripts (NATs), regulate their progenitors’ expression by competing for the same microRNAs, and provide a sequence to lncRNA and novel exons to existing protein-coding genes. …”
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74582por Ku, Yee-Shan, Lin, Xiao, Fan, Kejing, Cheng, Sau-Shan, Chan, Ting-Fung, Chung, Gyuhwa, Lam, Hon-Ming“…Natural antisense transcripts (NATs) have been generally reported as negative regulators of their sense counterparts. …”
Publicado 2022
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74583por Tian, Yanhua, Li, Qingqing, Yang, Zhenlin, Zhang, Shu, Xu, Jiachen, Wang, Zhijie, Bai, Hua, Duan, Jianchun, Zheng, Bo, Li, Wen, Cui, Yueli, Wang, Xin, Wan, Rui, Fei, Kailun, Zhong, Jia, Gao, Shugeng, He, Jie, Gay, Carl M., Zhang, Jianjun, Wang, Jie, Tang, Fuchou“…Here, we performed high-precision single-cell transcriptomic analysis of ~5000 individual cells from primary tumors (PTs) and matched normal adjacent tissues (NATs) from 11 SCLC patients, including one patient with both PT and relapsed tumor (RT). …”
Publicado 2022
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74584por Bai, Youhuang, Dai, Xiaozhuan, Li, Yi, Wang, Lulu, Li, Weimin, Liu, Yanhui, Cheng, Yan, Qin, Yuan“…Here, we analyzed the available RNA-seq data sets derived from 26 pineapple leaf samples at 13 time points and identified 2,888 leaf lncRNAs, including 2,046 long intergenic noncoding RNAs (lincRNAs) and 842 long noncoding natural antisense transcripts (lncNATs). Pineapple leaf lncRNAs are expressed in a highly tissue-specific manner. …”
Publicado 2019
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74585por Huggins, Ian J., Medina, Carlos A., Springer, Aaron D., van den Berg, Arjen, Jadhav, Satish, Cui, Xianshu, Dowdy, Steven F.“…Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. …”
Publicado 2019
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74586por Chen, Rui, Li, Ming, Zhang, Huiyuan, Duan, Lijin, Sun, Xianjun, Jiang, Qiyan, Zhang, Hui, Hu, Zheng“…Strand-specific whole transcriptome sequencing and stringent bioinformatic analysis led to the identification of 3030 long intergenic non-coding RNAs (lincRNAs) and 275 natural antisense transcripts (lncNATs) in soybean roots. In contrast to mRNAs, newly identified lncRNAs exhibited less exons, similar AU content to UTRs, even distribution across the genome and low evolutionary conservation. …”
Publicado 2019
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74587por Lin, Zheguang, Liu, Yibing, Chen, Xiaomei, Han, Cong, Wang, Wei, Ke, Yalu, Su, Xiaoling, Li, Yujiao, Chen, Heng, Xu, Hao, Chen, Guohong, Ji, Ting“…By means of a lncRNA identification pipeline, 6,645 novel lncRNA transcripts, encoded by 3,897 gene loci, were identified, including 2,066 sense lncRNAs, 2,772 lincRNAs, and 1,807 lncNATs. Compared with protein-coding mRNAs, V. destructor lncRNAs are shorter in terms of full length, as well as of the ORF length, contain less exons, and express at lower level. …”
Publicado 2020
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74588por Li, Juzuo, Li, Ning, Zhu, Ling, Zhang, Zhibin, Li, Xiaochong, Wang, Jinbin, Xun, Hongwei, Zhao, Jing, Wang, Xiaofei, Wang, Tianya, Wang, Hongyan, Liu, Bao, Li, Yu, Gong, Lei“…In this study, we characterized and compared the profiles of genome-wide lncRNA profiles (including long intergenic non-coding RNAs [lincRNAs] and long noncoding natural antisense transcripts [lncNATs]) of a null mutant of the rice DNA methyltransferase 1, OsMET1-2 (designated OsMET1-2(−)(/)(−)) and its isogenic wild type (OsMET1-2(+/+)). …”
Publicado 2021
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74589por Wang, Jin-Sook, Sim, Hyo-Jung, Park, Su-Jin, Park, Gye-Ryeng, Kang, Chun, Chung, Yoon-Seok“…The Korea Disease Control and Prevention Agency (KDCA) has further included p24 antigen neutralization and nucleic acid tests (NATs) since 2015. Our study aimed to investigate the effect of this new testing algorithm on the confirmation rate of HIV infection. …”
Publicado 2021
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74590“…RNA-sequencing was conducted in four pairs of ESCC tissues and normal adjacent tissues (NATs). Compared with controls, lncRNA VPS9D1-AS1 was highly expressed in ESCC tissues, cell lines and plasma. …”
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74591por Lembke, Carolina Gimiliani, Nishiyama, Milton Yutaka, Sato, Paloma Mieko, de Andrade, Rodrigo Fandiño, Souza, Glaucia Mendes“…Our custom sugarcane oligonucleotide array provides sensitivity and good coverage of sugarcane transcripts for the identification of a representative proportion of natural antisense transcripts (NATs) and sense-antisense transcript pairs (SATs). …”
Publicado 2012
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74592“…The expression of SOX8 was higher in CRC tissues than that in non-tumor adjacent tissues (NATs, P <.001). High expression of SOX8 was associated with tumor stage (P = .04) and shorter overall survival (OS) after operation of patients (P = .004). …”
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74593por Mainardi, Victoria, Gerona, Solange, Ardao, Gonzalo, Ferreira, Noelia, Ramírez, Gabriel, Arbiza, Juan, Mirazo, Santiago“…CONCLUSIONS: The differential diagnosis of persistently elevated transaminases in transplanted and/or immunocompromised patients should include testing for HEV by appropriate nucleic acid techniques (NATs). Cases of HEV infection with an atypical clinical outcome, such as the one presented herein, highlights the need for increased awareness of chronic hepatitis E and its association with a wide range of extrahepatic manifestations.…”
Publicado 2019
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74594“…Multicellular organoids were established using Primary cells isolated from tumor tissues, histologically normal tissues adjacent to the tumors (NATs) and adipose tissues (source of Mesenchymal Stem Cells) from ovarian and breast cancer patients. …”
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74595por Nolasco, Sofia, Bellido, Javier, Gonçalves, João, Tavares, Alexandra, Zabala, Juan Carlos, Soares, Helena“…These molecules might result from antisense transcription of functional genes originating natural antisense transcripts (NATs) or from transcriptional active pseudogenes. …”
Publicado 2012
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74596por Bazin, Jérémie, Baerenfaller, Katja, Gosai, Sager J., Gregory, Brian D., Crespi, Martin, Bailey-Serres, Julia“…Furthermore, we discovered that natural antisense transcripts (NATs) frequently have actively translated sORFs, including five with low-Pi up-regulation that correlated with enhanced translation of the sense protein-coding mRNA. …”
Publicado 2017
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74597por Miguéis, Graciela da Silva, da Silva, Rosa Helena, Damasceno Júnior, Geraldo Alves, Guarim-Neto, Germano“…The diversity index was 4.5 nats/ind(-1). The body system with the most citations was the code XVIII of ICD 10, corresponding to the species: alfavaca, mentraste, terramicina, angelim, fedegoso. …”
Publicado 2019
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74598“…SETTING: An analysis based on the cross-sectional 2009–2010 National Adult Tobacco Survey (NATS). PARTICIPANTS: 11 766 current smokers aged 18 or above in the USA. …”
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74599“…Around 40 % of the lncRNAs showed sequence similarity with small RNAs (sRNA), while 1.53 % were predicted to be sunflower natural antisense transcripts (NATs), and 9.18 % contained transposable elements (TE). …”
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74600“…METHODS: We used using data from the 2013–2014 National Adult Tobacco Survey (NATS) to estimate prevalence of e-cigarette promotions received by mail or email. …”
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