“…BACKGROUND: This study describes a large-scale manual re-annotation of data samples in the Gene Expression Omnibus (GEO), using variables and values derived from the National Cancer Institute thesaurus. A framework is described for creating an annotation scheme for various diseases that is flexible, comprehensive, and scalable. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this study four and five-feature pharmacophores for selective antagonists at each of the three α(1)-adrenoceptor (AR) subtypes were used to identify novel α(1)-AR subtype selective compounds in the National Cancer Institute and Tripos LeadQuest databases. 12 compounds were selected, based on diversity of structure, predicted high affinity and selectivity at the α(1D)- subtype compared to α(1A)- and α(1B)-ARs. 9 out of 12 of the tested compounds displayed affinity at the α(1A) and α(1D) -AR subtypes and 6 displayed affinity at all three α(1)-AR subtypes, no α(1B)-AR selective compounds were identified. 8 of the 9 compounds with α(1)-AR affinity were antagonists and one compound displayed partial agonist characteristics. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In 1992, an international workshop sponsored by the United States National Cancer Institute concluded that there was an “emerging epidemic” of NHL and emphasized the need to investigate the factors responsible for the increasing incidence of this disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To that end, this review describes methods for interactive comparisons of proprietary new technologies, clinical trial designs, a clinical validation qualification strategy, and an approach for effectively carrying out this work through a public-private partnership that includes test developers, drug developers, clinical trialists, the US Food & Drug Administration (FDA) and the US National Cancer Institute (NCI).…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Rapamycin has proven to be a versatile compound with several seemingly unrelated properties, including antifungal, immunosuppressive, and anticancer. The National Cancer Institute (NCI) Developmental Therapeutics Program demonstrated that rapamycin inhibited cell growth in tumor cell lines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In 2011, The National Cancer Institute (NCI) has announced 24 provocative questions on cancer. …”
Enlace del recurso
Enlace del recurso

“…The gene expression profiles of 37 disc tissue samples obtained from patients with herniated discs and degenerative disc disease collected by the National Cancer Institute Cooperative Tissue Network were analyzed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In 1997, an international collaborative workshop sponsored by the National Cancer Institute (NCI) proposed a set of guidelines for MSI-testing to improve reliability and reproducibility of the analysis as well to allow comparisons between different studies and different laboratories. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A case in point is the set of pharmacogenomic studies that we and our collaborators have done with the 60 human cancer cell lines of the National Cancer Institute’s drug discovery program. Those cells (the NCI-60) have been characterized pharmacologically with respect to their sensitivity to > 70,000 chemical compounds. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The compounds were screened for anticancer activity as per National Cancer Institute (NCI US) protocol on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancers cell lines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The anticancer activities were evaluated on a panel of 60 cell lines by the National Cancer Institute according to its own screening protocol. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…On February 2, 2012, the National Cancer Institute (NCI) sponsored a 2-day workshop with the NCI Thoracic Malignancies Steering Committee and the Food and Drug Administration to bring together leading academicians, clinicians, industry and government representatives to identify challenges and potential solutions in the clinical development of novel targeted therapies for lung cancer. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Data were collected using a validated self-administered questionnaire adopted from the National Cancer Institute in USA, customized by adding and eliminating questions to be in line with the institution (NGHA) characteristics. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…ABBREVIATIONS: MTB - Mycobacterium tuberculosis, NCI - National Cancer Institute, PDB - Protein Databank.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also review the IOM recommendations; highlight the work done by the National Consensus Project in promoting quality PC; and discuss a National Cancer Institute–funded program project currently conducted at a National Comprehensive Cancer Center, "Palliative Care for Quality of Life and Symptoms Concerns in Lung Cancer," which serves as a model to promote high-quality care for patients and their families.…”
Enlace del recurso
Enlace del recurso

“…Our process parallels the National Cancer Institute’s Research-Tested Intervention Programs (RTIPs) guidelines for adapting evidence-based programs for cancer populations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We used the National Cancer Institute (NCI) method to assess usual intake of 21 micronutrients and the percentage of the population under EARs and above Tolerable Upper Intake Levels (UL). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Dental status and oral mucosa were examined using the criteria of the National Cancer Institute Toxicity Criteria Scale. The levels of stimulated and unstimulated saliva flow were analysed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Keynote addresses will be given by academic and industry experts Douglas Lauffenburger (Massachusetts Institute of Technology), Ira Pastan (National Cancer Institute), James Wells (University of California, San Francisco), Ian Tomlinson (GlaxoSmithKline) and Anthony Rees (Rees Consulting AB and Emeritus Professor, University of Bath). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Combined with initiatives like the National Cancer Institute Genomics Cloud Pilots, such data resources will make intensive analysis of large-scale cancer genomics data widely accessible. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso