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21“…Here we report the characterization of a homopentameric ionotropic acetylcholine receptor (AChR), ACR-16, from Necator americanus and Ancylostoma ceylanicum, the first known characterization of human hookworm ion channels. …”
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22por Jenkins, Timothy P., Pritchard, David I., Tanasescu, Radu, Telford, Gary, Papaiakovou, Marina, Scotti, Riccardo, Cortés, Alba, Constantinescu, Cris S., Cantacessi, Cinzia“…RESULTS: In the present study, we investigated, for the first time, qualitative and quantitative changes in the faecal bacterial composition of human volunteers with remitting multiple sclerosis (RMS) prior to and following experimental infection with the human hookworm, Necator americanus (N+), and following anthelmintic treatment, and compared the findings with data obtained from a cohort of RMS patients subjected to placebo treatment (PBO). …”
Publicado 2021
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23por Gandasegui, Javier, Grau-Pujol, Berta, Cambra-Pelleja, María, Escola, Valdemiro, Demontis, Maria Antonietta, Cossa, Anelsio, Jamine, José Carlos, Balaña-Fouce, Rafael, van Lieshout, Lisette, Muñoz, José, Martínez-Valladares, María“…In this study, we optimized the stool sample processing methodology and resistance allele frequency assessment in Trichuris trichiura and Necator americanus anthelmintic-related SNPs by pyrosequencing, and standardized it for large-scale benzimidazole efficacy screening use. …”
Publicado 2021
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24por Mugambi, Robert Muriuki, Agola, Eric L., Mwangi, Ibrahim N., Kinyua, Johnson, Shiraho, Esther Andia, Mkoji, Gerald M.“…BACKGROUND: Hookworm infection is a major concern in sub-Saharan Africa, particularly in children and pregnant women. Necator americanus and Ancylostoma duodenale are responsible for this condition. …”
Publicado 2015
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25por Zuccherato, Luciana Werneck, Furtado, Luis Fernando, Medeiros, Celi da Silva, Pinheiro, Carina da Silva, Rabelo, Élida M.“…Ascaris lumbricoides and Necator americanus are soil-transmitted parasites with global geographic distribution, and they represent some of the most common and neglected infections in the world. …”
Publicado 2018
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26por Asojo, Oluwatoyin A, Homma, Kohei, Sedlacek, Meghan, Ngamelue, Michelle, Goud, Gaddam N, Zhan, Bin, Deumic, Vehid, Asojo, Oluyomi, Hotez, Peter J“…RESULTS: The crystal structures of Na-GST-1 and Na-GST-2, two major GSTs from Necator americanus the main human hookworm parasite, have been solved at the resolution limits of 2.4 Å and 1.9 Å respectively. …”
Publicado 2007
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27por Agyapong, Odame, Asiedu, Seth O., Kwofie, Samuel K., Miller, Whelton A., Parry, Christian S., Sowah, Robert A., Wilson, Michael D.“…The present work utilized pharmacoinformatics techniques to predict African natural compounds ZINC95486082, ZINC95486052 and euphohelionon as potential inhibitory molecules of the hookworm Necator americanus β tubulin gene. A library of 3390 compounds was screened against a homology-modelled structure of β tubulin. …”
Publicado 2021
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28por Curti, Elena, Seid, Christopher A, Hudspeth, Elissa, Center, Lori, Rezende, Wanderson, Pollet, Jeroen, Kwityn, Cliff, Hammond, Molly, Matsunami, Rise K, Engler, David A, Hotez, Peter J, Elena Bottazzi, Maria“…Infection by the human hookworm Necator americanus is a leading cause of anemia and disability in the developing countries of Africa, Asia, and the Americas. …”
Publicado 2014
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29por Rey-Burusco, M. Florencia, Ibáñez-Shimabukuro, Marina, Gabrielsen, Mads, Franchini, Gisela R., Roe, Andrew J., Griffiths, Kate, Zhan, Bin, Cooper, Alan, Kennedy, Malcolm W., Córsico, Betina, Smith, Brian O.“…We have therefore examined [Necator americanus FAR-1 (Na-FAR-1)] from the blood-feeding intestinal parasite of humans, N. americanus. …”
Publicado 2015
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30por El Atab, Ola, Darwiche, Rabih, Truax, Nathanyal J., Schneiter, Roger, Hull, Kenneth G., Romo, Daniel, Asojo, Oluwatoyin A.Enlace del recurso
Publicado 2020
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31por Colella, Vito, Khieu, Virak, Worsley, Andrew, Senevirathna, Dammika, Muth, Sinuon, Huy, Rekol, Odermatt, Peter, Traub, Rebecca J.Enlace del recurso
Publicado 2021
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32por Hughes, Angus, Ng-Nguyen, Dinh, Clarke, Naomi E., Dyer, Clare E. F., Hii, Sze Fui, Clements, Archie C. A., Anderson, Roy M., Gray, Darren J., Coffeng, Luc E., Kaldor, John M., Traub, Rebecca J., Vaz Nery, Susana“…RESULTS: The predominant STH species was the hookworm Necator americanus (overall cluster-adjusted prevalence of 13.7%), and its prevalence was heterogeneously distributed across surveyed schools (0% to 56.3%). …”
Publicado 2023
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33por Pearson, Mark S., Bethony, Jeffrey M., Pickering, Darren A., de Oliveira, Luciana M., Jariwala, Amar, Santiago, Helton, Miles, Aaron P., Zhan, Bin, Jiang, Desheng, Ranjit, Najju, Mulvenna, Jason, Tribolet, Leon, Plieskatt, Jordan, Smith, Tracey, Bottazzi, Maria Elena, Jones, Kathryn, Keegan, Brian, Hotez, Peter J., Loukas, Alex“…An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection.…”
Publicado 2009
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34por Gabrielsen, Mads, Rey-Burusco, M. Florencia, Griffiths, Kate, Roe, Andrew J., Cooper, Alan, Smith, Brian O., Kennedy, Malcolm W., Corsico, Betina“…Na-FAR-1 is an unusual α-helix-rich fatty acid- and retinol-binding protein from Necator americanus, a blood-feeding intestinal parasitic nematode of humans. …”
Publicado 2012
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35por George, Santosh, Suwondo, Peter, Akorli, Jewelna, Otchere, Joseph, Harrison, Lisa M., Bilguvar, Kaya, Knight, James R., Humphries, Debbie, Wilson, Michael D., Caccone, Adalgisa, Cappello, Michael“…In Ghana, previous studies have demonstrated significant variability in albendazole effectiveness among people infected with the hookworm Necator americanus, although the mechanisms underlying deworming response have not been defined. …”
Publicado 2022
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36por Seid, Christopher A, Curti, Elena, Jones, R Mark, Hudspeth, Elissa, Rezende, Wanderson, Pollet, Jeroen, Center, Lori, Versteeg, Leroy, Pritchard, Sonya, Musiychuk, Konstantin, Yusibov, Vidadi, Hotez, Peter J, Bottazzi, Maria Elena“…Over 400 million people living in the world's poorest developing nations are infected with hookworms, mostly of the genus Necator americanus. A bivalent human hookworm vaccine composed of the Necator americanus Glutathione S-Transferase-1 (Na-GST-1) and the Necator americanus Aspartic Protease-1 (Na-APR-1 (M74)) is currently under development by the Sabin Vaccine Institute Product Development Partnership (Sabin PDP). …”
Publicado 2015
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37por Chapman, Paul R, Webster, Rebecca, Giacomin, Paul, Llewellyn, Stacey, Becker, Luke, Pearson, Mark S, De Labastida Rivera, Fabian, O'Rourke, Peter, Engwerda, Christian R, Loukas, Alex, McCarthy, James S“…METHODS: This was a two-part clinical trial done at Q-Pharm in Brisbane (QLD, Australia) using a live ultraviolet C (UVC)-attenuated Necator americanus larvae vaccine. Part one was an open-label, dose-finding study using 50 L3 larvae suspended in water to a volume of 200 μL, attenuated with UVC exposure of 700 μJ (L3–700) or 1000 μJ (L3–1000). …”
Publicado 2021
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38por Asojo, Oluwatoyin A., Loukas, Alex, Inan, Mehmet, Barent, Rick, Huang, Jicai, Plantz, Brad, Swanson, Amber, Gouthro, Mark, Meagher, Michael M., Hotez, Peter J.Enlace del recurso
Publicado 2010
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40por Rey-Burusco, M. Florencia, Ibañez-Shimabukuro, Marina, Cooper, Alan, Kennedy, Malcolm W., Córsico, Betina, Smith, Brian O.“…Na-FAR-1 is from the parasitic nematode Necator americanus, an intestinal blood-feeding parasite of humans. …”
Publicado 2012
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