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841“…Here we describe the non-canonical control of gene expression in Leishmania, a single-cell parasite that is responsible for one of the major neglected tropical diseases. We discuss the lack of regulated RNA synthesis, the post-transcriptional gene regulation including RNA stability and regulated translation. …”
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842por Verrest, Luka, Wilthagen, Erica A., Beijnen, Jos H., Huitema, Alwin D. R., Dorlo, Thomas P. C.“…METHODS: A systematic review was performed on the effects of malnourishment on the pharmacokinetics of drugs to treat PRDs, including HIV, tuberculosis, malaria, and neglected tropical diseases. RESULTS: In 21/29 PRD drugs included in this review, pharmacokinetics were affected by malnutrition. …”
Publicado 2021
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843“…Cystic echinococcosis and human cysticercosis have recently been included in the list of “neglected tropical diseases” by the World Health Organization (WHO). …”
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844“…Chagas disease (infection by the protozoan Trypanosoma cruzi) is a major parasitic disease of the Americas and one of the main neglected tropical diseases. Although various routes of transmission sre recognized, the risk for transmission of the infection through breast-feeding has not clearly been established. …”
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845por Gilbert, Ian H.“…[Image: see text] Drug discovery for neglected tropical diseases is carried out using both target-based and phenotypic approaches. …”
Publicado 2013
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846“…Zoonotic trematode infections are an area of the neglected tropical diseases that have become of major interest to global and public health due to their associated morbidity. …”
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847“…With the inclusion of snakebite envenoming on the World Health Organization’s list of Neglected Tropical Diseases, an incentive has been established to promote research and development effort in novel snakebite antivenom therapies. …”
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848“…The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge. …”
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849por Leaver, David J.“…SDM has been demonstrated to be a valid drug target for antiprotozoal therapies, and much research has been focused on using SDM inhibitors to treat neglected tropical diseases such as human African trypanosomiasis (HAT), Chagas disease, and leishmaniasis. …”
Publicado 2018
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850por Pisarski, Konrad“…This unfortunately detracts attention from the many emerging zoonoses that fall under the radar as neglected tropical diseases (NTDs). This review considers the available literature and the attribution of burden of disease to the most insidious NTDs and recommends which five are deserving of policy prioritisation. …”
Publicado 2019
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851“…Leishmaniasis is one of eight neglected tropical diseases currently endemic in 102 countries/areas around the world. …”
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852por Squarre, David, Chambaro, Herman M., Hayashida, Kyoko, Moonga, Lavel C., Qiu, Yongjin, Goto, Yasuyuki, Oparaocha, Elizabeth, Mumba, Chisoni, Muleya, Walter, Bwalya, Patricia, Chizimu, Joseph, Chembensofu, Mwelwa, Simulundu, Edgar, Mwasinga, Wizaso, Banda, Nelly, Mwenda, Racheal, Yamagishi, Junya, Nalubamba, King S., Banda, Fredrick, Munyeme, Musso, Sawa, Hirofumi, Fandamu, Paul“…Leishmaniases are neglected tropical diseases of humans and animals. We detected Leishmania infantum in 3 mixed-breed dogs in Zambia that had no travel history outside the country. …”
Publicado 2022
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853por HAY, Roderick J.“…Along with common diseases such as pyodermas and fungal infections, a group of conditions known collectively as the neglected tropical diseases of the skin or Skin NTDs, which are the targets for worldwide control or elimination are also seen in health care facilities. …”
Publicado 2020
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854“…Filarial infections caused by nematodes are one of the major neglected tropical diseases with public health concern. Although there is significant decrease in microfilariae (mf) prevalence following mass drug administration (IVM/DEC/ALB administration), this is transient, in that there is reported microfilaria repopulation 6-12 months after treatment. …”
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855por Lakwo, Thomson, Ukety, Tony, Bakajika, Didier, Tukahebwa, Edridah, Awaca, Pitchouna, Amazigo, Uche“…This highlighted the need for multilateral organisations such as the Expanded Special Project for the Elimination of Neglected Tropical Diseases in cross-border activities for other Neglected Tropical Diseases. …”
Publicado 2018
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856“…Human African trypanosomiasis (HAT, or sleeping sickness) is a protozoan parasitic infection caused by Trypanosoma brucei rhodesiense or Trypanosoma brucei gambiense. These are neglected tropical diseases, and T.b. rhodesiense HAT is a zoonosis. …”
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857por Maltezou, Helena C.“…This illness was included by the World Health Organization in the list of neglected tropical diseases targeted for elimination by 2015. …”
Publicado 2010
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858por Pandey, Krishna, Sinha, Prabhat Kumar, Das, Vidyanand Ravi, Bimal, Sanjiva, Singh, Shubhankar K., Das., Pradeep“…Visceral leishmaniasis (VL) or Kala-azar is a protozoal disease, which was previously regarded as one of the most neglected tropical diseases. Management of this disease is quite difficult, because it is said to affect the poorest of the poor. …”
Publicado 2009
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859“…The findings from the review support the development of an LF-specific disability measurement tool and raise doubt about the suitability of generic disability tools to assess disability related to neglected tropical diseases (NTDs) globally.…”
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860por Zhou, Xiao-Nong“…Infectious diseases of poverty, a collective term coined for infections known to be particularly prevalent amongst poor populations, is increasingly used for neglected tropical diseases (NTDs) with special transmission routes, such as depending on vectors and/or intermediate hosts. …”
Publicado 2012
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