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1461por Van Leuvenhaege, Chloé, Vandelannoote, Koen, Affolabi, Dissou, Portaels, Françoise, Sopoh, Ghislain, de Jong, Bouke C., Eddyani, Miriam, Meehan, Conor J.“…Our study proposes a pipeline for such studies and highlights several drawbacks that must be considered if microbiome analysis is to be utilized for neglected tropical diseases.…”
Publicado 2017
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1462por Piseddu, Toni, Brundu, Diego, Stegel, Giovanni, Loi, Federica, Rolesu, Sandro, Masu, Gabriella, Ledda, Salvatore, Masala, Giovanna“…BACKGROUND: Cystic echinococcosis (CE) is an important neglected zoonotic parasitic infection belonging to the subgroup of seven Neglected Zoonotic Disease (NZDs) included in the World Health Organization’s official list of 18 Neglected Tropical Diseases (NTDs). CE causes serious global human health concerns and leads to significant economic losses arising from the costs of medical treatment, morbidity, life impairments and fatality rates in human cases. …”
Publicado 2017
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1463por Holmström, Oscar, Linder, Nina, Ngasala, Billy, Mårtensson, Andreas, Linder, Ewert, Lundin, Mikael, Moilanen, Hannu, Suutala, Antti, Diwan, Vinod, Lundin, Johan“…Background: Microscopy remains the gold standard in the diagnosis of neglected tropical diseases. As resource limited, rural areas often lack laboratory equipment and trained personnel, new diagnostic techniques are needed. …”
Publicado 2017
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1464por Shiff, Clive“…With the increased availability of this drug, there has been an increasing interest in readdressing schistosomes as well as other neglected tropical diseases (NTDs). The strategic approach for this had been based almost exclusively on chemotherapy. …”
Publicado 2017
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1465por Deribe, Kebede, Cano, Jorge, Giorgi, Emanuele, Pigott, David M., Golding, Nick, Pullan, Rachel L., Noor, Abdisalan M., Cromwell, Elizabeth A., Osgood‐Zimmerman, Aaron, Enquselassie, Fikre, Hailu, Asrat, Murray, Christopher J. L., Newport, Melanie J., Brooker, Simon J., Hay, Simon I., Davey, Gail“…Background: In 2011, the World Health Organization recognized podoconiosis as one of the neglected tropical diseases. Nonetheless, the magnitude of podoconiosis and the geographical distribution of the disease is poorly understood. …”
Publicado 2017
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1466por González, Camila, León, Cielo, Paz, Andrea, López, Marla, Molina, Gisell, Toro, Diana, Ortiz, Mario, Cordovez, Juan Manuel, Atencia, María Claudia, Aguilera, Germán, Tovar, Catalina“…Leishmaniases are neglected tropical diseases exhibiting complex transmission cycles due to the number of parasite species circulating, sand fly species acting as vectors and infected mammals, including humans, which are defined in the New World as accidental hosts. …”
Publicado 2018
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1467por Cunningham, Lucas J., Odoom, John, Pratt, Deborah, Boatemaa, Linda, Asante-Ntim, Nana, Attiku, Keren, Banahene, Bismarck, Osei-Atweneboana, Mike, Verweij, Jaco J., Molyneux, David, Stothard, Russell J., Adams, Emily R.“…Here we explore collaborative opportunities with the GPLN to target two of the 18 diseases listed as a neglected tropical diseases (NTD) namely soil transmitted helminthiasis (STH) and Schistosomiasis (SCH). …”
Publicado 2018
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1468por Bennis, Issam, De Brouwere, Vincent, Belrhiti, Zakaria, Sahibi, Hamid, Boelaert, Marleen“…BACKGROUND: Cutaneous Leishmaniasis (CL) is a parasitic skin disease, linked to poverty, and belonging to the group of Neglected Tropical Diseases. Depending on the severity, the type of lesions or scars, and the context, CL can lead to self- and social stigma influencing the quality of life and psychological well-being of the patient. …”
Publicado 2018
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1469por Awah, Paschal Kum, Boock, Alphonse Um, Mou, Ferdinand, Koin, Joseph Tohnain, Anye, Evaristus Mbah, Noumen, Djeunga, Nichter, Mark“…CONCLUSION/ SIGNIFICANCE: Setting up lines of communication, and promoting collaboration and trust between community stakeholders and health staff is essential to the control of neglected tropical diseases. It is also essential to health system strengthening and emerging disease preparedness. …”
Publicado 2018
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1470por Tembei, Ayok M., Kengne-Ouaffo, Jonas A., Ngoh, Elvis A., John, Bonekeh, Nji, Theobald M., Deribe, Kebede, Enyong, Peter, Nkuo-Akenji, Theresa, Davey, Gail, Wanji, Samuel“…Leprosy and podoconiosis (podo) are neglected tropical diseases that cause severe disfigurement and disability, and may lead to catastrophic health expenditure and hinder economic development of affected persons and households. …”
Publicado 2018
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1471“…BACKGROUND: Schistosomiasis is one of the most disabling neglected tropical diseases, ranking second in terms of years lived with disability. …”
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1472por Khosravi, Ahmad, Sharifi, Iraj, Tavakkoli, Hadi, Derakhshanfar, Amin, Keyhani, Ali Reza, Salari, Zohreh, Mosallanejad, Seyedeh Saedeh, Bamorovat, Mehdi“…Leishmaniasis is one of the diverse and neglected tropical diseases. Embryo-toxicity of drugs has always been a major concern. …”
Publicado 2018
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1473por Atcheson, Erwan, Bauza, Karolis, Salman, Ahmed M., Alves, Eduardo, Blight, Joshua, Viveros-Sandoval, Martha Eva, Janse, Chris J., Khan, Shahid M., Hill, Adrian V. S., Reyes-Sandoval, Arturo“…Vivax malaria remains one of the most serious and neglected tropical diseases, with 132 to 391 million clinical cases per year and 2.5 billion people at risk of infection. …”
Publicado 2018
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1474por Thakur, Lovlesh, Singh, Kiran K., Shanker, Vinay, Negi, Ajeet, Jain, Aklank, Matlashewski, Greg, Jain, Manju“…BACKGROUND: Among the neglected tropical diseases, leishmaniasis continues to be prevalent in many tropical and subtropical countries despite international, national, and local efforts towards its control and elimination over the last decade. …”
Publicado 2018
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1475por Janes, Jeff, Young, Megan E., Chen, Emily, Rogers, Nicole H., Burgstaller-Muehlbacher, Sebastian, Hughes, Laura D., Love, Melissa S., Hull, Mitchell V., Kuhen, Kelli L., Woods, Ashley K., Joseph, Sean B., Petrassi, H. Michael, McNamara, Case W., Tremblay, Matthew S., Su, Andrew I., Schultz, Peter G., Chatterjee, Arnab K.“…The chemical diversity and known safety profiles of drugs previously tested in humans make them a valuable set of compounds to explore potential therapeutic utility in indications outside those originally targeted, especially neglected tropical diseases. This practice of “drug repurposing” has become commonplace in academic and other nonprofit drug-discovery efforts, with the appeal that significantly less time and resources are required to advance a candidate into the clinic. …”
Publicado 2018
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1476por Whiteland, Helen L., Chakroborty, Anand, Forde-Thomas, Josephine E., Crusco, Alessandra, Cookson, Alan, Hollinshead, Jackie, Fenn, Caroline A., Bartholomew, Barbara, Holdsworth, Peter A., Fisher, Maggie, Nash, Robert J., Hoffmann, Karl F.“…Two economically and biomedically important platyhelminth species, Fasciola hepatica (liver fluke) and Schistosoma mansoni (blood fluke), are responsible for the neglected tropical diseases (NTDs) fasciolosis and schistosomiasis. …”
Publicado 2018
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1477por Behrens, Anna-Janina, Duke, Rebecca M., Petralia, Laudine M. C., Lehoux, Sylvain, Carlow, Clotilde K. S., Taron, Christopher H., Foster, Jeremy M.“…D. immitis is closely related to Onchocerca volvulus, Wuchereria bancrofti and Brugia malayi, which cause onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) in humans and are neglected tropical diseases. Serum N-glycosylation is very sensitive to both pathological infections and changes in mammalian biology due to normal aging or lifestyle choices. …”
Publicado 2018
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1478“…The World Health Organization (WHO) and other international collaborating partners provided updates on the Product, Price and Procurement database, the prequalification of vaccines, the control of neglected tropical diseases, particularly the new rabies elimination initiative, and regulatory convergence proposals to accelerate vaccine registration in developing countries. …”
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1479por Kovářová, Julie, Nagar, Rupa, Faria, Joana, Ferguson, Michael A. J., Barrett, Michael P., Horn, David“…Indeed, the pathway has long been considered a potential therapeutic target to tackle the devastating and neglected tropical diseases caused by these parasites. However, plasma membrane glucose and glycerol transporters are both expressed by trypanosomes and these parasites can infiltrate tissues that contain glycerol. …”
Publicado 2018
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1480AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasispor Hong, W. David, Benayoud, Farid, Nixon, Gemma L., Ford, Louise, Johnston, Kelly L., Clare, Rachel H., Cassidy, Andrew, Cook, Darren A. N., Siu, Amy, Shiotani, Motohiro, Webborn, Peter J. H., Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J., Ehrens, Alexandra, Hübner, Marc P., Hoerauf, Achim, Roberts, Adam P., Hubbard, Alasdair T. M., Tate, Edward W., Serwa, Remigiusz A., Leung, Suet C., Qie, Li, Berry, Neil G., Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., O’Neill, Paul M.“…Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. …”
Publicado 2019
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