“…METHODS: The study population included older adults previously diagnosed with MDD and a cohort of never-depressed older adults, both of whom have been enrolled in the N-BOLD study at the University of Connecticut Health Center. …”
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“…Through InnoCentive, a platform that leverages the ability to connect to a whole planet of people through the Internet, organizations can access individuals – problem solvers – who might never have been found. Alph spent more than 25 years with Eli Lilly and Company, and offers deep experience in pharmaceutical research and development, research acquisitions and collaborations, and R&D strategic planning. …”
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“…CASE DESCRIPTION: A 31-year-old woman, with a background of seropositive (anti-CCP 261 and RF 30), non-erosive rheumatoid arthritis (RA) diagnosed 6 years ago and recent onset of subcutaneous nodules presented with a large right sided spontaneous pneumothorax. She was a never smoker and had no significant family history. …”
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“…She stressed “as a patient never give up hope that you will be able to recover something that you feared lost.” …”
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“…Mean(SD) TED duration was 5.2(1.8) yrs. 87.1% were never/former smokers. At BL, mean(SD) proptosis was 24.4(2.94) mm, mean CAS was 0.4, and 29% (teprotumumab, n=14, PBO, n=4) had diplopia with a mean score ∼2. 93%(39) of teprotumumab pts completed the study. …”
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“…The gross appearance of the lesion produced even by a virulent streptococcus is, as a rule, that of a lobular pneumonia and is practically never accompanied by pleurisy. In the few instances in which large quantities of the streptococcus were given and the outward appearance of the lungs approached that of a lobar pneumonia, it was found that on section of the consolidated lung the solid foci proved to be separated by lighter areas of aerated, congested lung. …”
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“…It is true that we have never succeeded in producing acute toxic symptoms either in the whole animal or in the isolated uterus with serum from animals acutely ill. …”
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“…Cultures found to contain Staphylococcus albus have never been judged significant. Margolis and Dorsey (11) have excluded Gram-positive bacilli from their series, but have included diphtheroids. …”
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“…And last but not least, it is a golden chance for penniless PhD students to spend a couple of extra days visiting a foreign country (this motivation will of course never be voiced to supervisors). The network of participating institutes has a three-nation core, made up of the Netherlands Cancer Institute, the Italian European School of Molecular Medicine (SEMM) and five UK Cancer Research Institutes (The London Research Institute, The Cambridge Research Institute, The Beatson Institute for Cancer Research in Glasgow, The Patterson Institute for Cancer Research in Manchester and the MRC Gray Institute for Radiation Oncology and Biology in Oxford). …”
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“…The evidence from all 117 clusters showed that no cases of Ebola virus disease occurred 10 days or more after randomisation among all immediately vaccinated contacts and contacts of contacts versus 23 cases (11 clusters affected) among all eligible contacts and contacts of contacts in delayed plus all eligible contacts and contacts of contacts never vaccinated in immediate clusters. The estimated vaccine efficacy here was 100% (95% CI 79·3–100·0, p=0·0033). 52% of contacts and contacts of contacts assigned to immediate vaccination and in non-randomised clusters received the vaccine immediately; vaccination protected both vaccinated and unvaccinated people in those clusters. 5837 individuals in total received the vaccine (5643 adults and 194 children), and all vaccinees were followed up for 84 days. 3149 (53·9%) of 5837 individuals reported at least one adverse event in the 14 days after vaccination; these were typically mild (87·5% of all 7211 adverse events). …”
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“…Quitting smoking is associated with an increased risk of developing ulcerative colitis. Therefore, never initiating smoking can mitigate the risk for IBD. …”
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“…ECM-based bioscaffolds placed at sites of neoplastic tissue resection in humans have never been reported to facilitate cancer recurrence. …”
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“…Stronger associations with infection death than with non-infection death were observed for advancing age (age 65 years vs 45 years: 7·59, 95% CI 5·92–9·73, for infection death vs 5·21, 4·97–5·48, for non-infection death), current smoking (vs never smoking: 3·69, 3·19–4·26, vs 2·52, 2·44–2·61), socioeconomic deprivation (most vs least deprived quintile: 2·13, 1·78–2·56, vs 1·38, 1·33–1·43), class 3 obesity (vs non-obese: 2·21, 1·74–2·82, vs 1·55, 1·44–1·66), hypertension (1·36, 1·22–1·53, vs 1·15, 1·12–1·18), respiratory disease (2·21, 1·96–2·50, vs 1·28, 1·24–1·32), chronic kidney disease (5·04, 4·28–7·31, vs 2·50, 2·20–2·84), psychiatric disease (1·56, 1·30–1·86, vs 1·23, 1·18–1·29), and chronic inflammatory and autoimmune rheumatological disease (2·45, 1·99–3·02, vs 1·41, 1·32–1·51). …”
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“…This fibrinolysis shutdown was never observed in clots from healthy controls and COVID-19 ward patients. …”
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“…Regarding treatment, pts were divided into two subgroups, 78% of them received anticancer therapy at least once in their lives, while 22% of them have never been on treatment, mainly pts with CLL and indolent NHL. 62% of the first subgroup manifested moderate/severe COVID-19 infection requiring hospitalization with 28% death rate, while the same rates in the 2 (nd) subgroup were 30% and 10% respectively. …”
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“…We defined overdiagnosis as the identification of high risk in individuals who, if not screened, would never have known that they were at risk and would never have experienced a fragility fracture. …”
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“…This phase has been labelled by some as ‘pre-clinical RA’, particularly when there are associated symptoms such as arthralgia or fatigue; however, some will never go on to develop clinical RA. In our patient who had evidence of inflammatory arthritis atypical for RA, the significance of her anti-CCP positivity is unclear. …”
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“…Controls were healthy volunteers who have never traveled to Southeast Asia (N=7). We measured IFN-γ release from: 1) rMp1p-stimulated whole blood using the enzyme linked immunosorbent assay (ELISA) and 2) rMp1p-stimulated peripheral blood mononuclear cells (PBMCs) using the enzyme-linked immunosorbent spot (ELISpot) method. …”
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