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441por Fessel, Jeffrey“…A paradox regarding Alzheimer’s dementia (AD) and mild cognitive impairment (MCI) is thats spontaneous cure of AD has never been reported, whereas spontaneous cure for MCI occurs fequently. …”
Publicado 2023
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442por Hamouz, Mohammad, Hammouz, Raneem Y., Bajwa, Muhammad Ahmed, Alsayed, Abdelrahman Waleed, Orzechowska, Magdalena, Bednarek, Andrzej K.“…There is currently a dearth of information regarding lung cancer in never smokers (LCINS). Additionally, there is a difference in somatic mutations, tumour mutational burden, and chromosomal aberrations between smokers and never smokers (NS), insinuating a different disease entity in LCINS. …”
Publicado 2023
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443por Choi, Eunji, Su, Chloe C., Wu, Julie T., Aredo, Jacqueline V., Neal, Joel W., Leung, Ann N., Backhus, Leah M., Lui, Natalie S., Le Marchand, Loïc, Stram, Daniel O., Liang, Su-Ying, Cheng, Iona, Wakelee, Heather A., Han, Summer S.“…As smoking rates continue to decline in the US, it is critical to examine more closely the epidemiology of lung cancer among patients who never smoked, including their risk for SPLC. OBJECTIVE: To estimate and compare the cumulative SPLC incidence among lung cancer survivors who have never smoked vs those who have ever smoked. …”
Publicado 2023
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444por Crispo, A, Brennan, P, Jöckel, K-H, Schaffrath-Rosario, A, Wichmann, H-E, Nyberg, F, Simonato, L, Merletti, F, Forastiere, F, Boffetta, P, Darby, SEnlace del recurso
Publicado 2004
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445por Minervini, Giovanni, Evangelista, Giuseppe, Polticelli, Fabio, Piwowar, Monika, Kochanczyk, Marek, Flis, Lukasz, Malawski, Maciej, Szepieniec, Tomasz, Wiśniowski, Zdzisław, Matczyńska, Ewa, Prymula, Katarzyna, Roterman, Irena“…The number of natural proteins although large is significantly smaller than the theoretical number of proteins that can be obtained combining the 20 natural amino acids, the so-called “never born proteins” (NBPs). The study of the structure and properties of these proteins allows to investigate the sources of the natural proteins being of unique characteristics or special properties. …”
Publicado 2008
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447por Santoro, Ilka Lopes, Ramos, Roberta Pulcheri, Franceschini, Juliana, Jamnik, Sergio, Fernandes, Ana Luisa Godoy“…OBJECTIVES: It has been recognized that patients with non-small cell lung cancer who are lifelong never-smokers constitute a distinct clinical entity. …”
Publicado 2011
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448por Li, Chenguang, Fang, Rong, Sun, Yihua, Han, Xiangkun, Li, Fei, Gao, Bin, Iafrate, A. John, Liu, Xin-Yuan, Pao, William, Chen, Haiquan, Ji, Hongbin“…PURPOSE: We previously showed that 90% (47 of 52; 95% CI, 0.79 to 0.96) of lung adenocarcinomas from East Asian never-smokers harbored well-known oncogenic mutations in just four genes: EGFR, HER2, ALK, and KRAS. …”
Publicado 2011
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449por Thirthalli, Jagadisha, Channaveerachari, Naveen Kumar, Subbakrishna, Doddaballapura K., Cottler, Linda B., Varghese, Mathew, Gangadhar, Bangalore N.“…AIM: The aim was to evaluate the association between DUP and outcome of never-treated schizophrenia patients. SETTING AND DESIGN: This study was conducted at the National Institute of Mental Health and Neurosciences, Bangalore, using a prospective cohort design. …”
Publicado 2011
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450“…In never-abducted children, more mental health problems were associated with experiencing physical harm, witnessing the killings of other people, and being forced to engage in sexual contact.…”
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451por Wang, Teresa W, Campbell, Josh D, Luo, Lingqi, Liu, Gang, Xiao, Ji, Lenburg, Marc E, Belinsky, Steven A, Spira, AvrumEnlace del recurso
Publicado 2012
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452por Mohammadpoorasl, Asghar, Nedjat, Saharnaz, Yazdani, Kamran, Fakhari, Ali, Foroushani, Abbas Rahimi, Fotouhi, Akbar“…The results showed that 95.0% of students were in committer stage (students who had never smoked and were sure never start smoking). …”
Publicado 2012
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454por Kim, Sang Cheol, Jung, Yeonjoo, Park, Jinah, Cho, Sooyoung, Seo, Chaehwa, Kim, Jaesang, Kim, Pora, Park, Jehwan, Seo, Jihae, Kim, Jiwoong, Park, Seongjin, Jang, Insu, Kim, Namshin, Yang, Jin Ok, Lee, Byungwook, Rho, Kyoohyoung, Jung, Yeonhwa, Keum, Juhee, Lee, Jinseon, Han, Jungho, Kang, Sangeun, Bae, Sujin, Choi, So-Jung, Kim, Sujin, Lee, Jong-Eun, Kim, Wankyu, Kim, Jhingook, Lee, Sanghyuk“…RESULTS: Here, we describe a high-throughput, multi-dimensional sequencing study of primary lung adenocarcinoma tumors and adjacent normal tissues of six Korean female never-smoker patients. Our data encompass results from exome-seq, RNA-seq, small RNA-seq, and MeDIP-seq. …”
Publicado 2013
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456por Reichrath, JörgEnlace del recurso
Publicado 2013
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457por Misailidi, Maria, Tzatzarakis, Manolis N., Kavvalakis, Mathaios P., Koutedakis, Yiannis, Tsatsakis, Aristidis M., Flouris, Andreas D.“…The objectives of this study were to: (i) to develop questionnaires that can identify never-smoking children and adults experiencing increased exposure to secondhand smoke (SHS+), (ii) to determine their validity against hair nicotine, and (iii) assess their reliability. …”
Publicado 2014
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458por Sierra, Amanda, Beccari, Sol, Diaz-Aparicio, Irune, Encinas, Juan M., Comeau, Samuel, Tremblay, Marie-ÈveEnlace del recurso
Publicado 2014
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459por Ahn, Jin Woo, Kim, Han Sang, Yoon, Jung-Ki, Jang, Hoon, Han, Soo Min, Eun, Sungho, Shim, Hyo Sup, Kim, Hyun-Jung, Kim, Dae Joon, Lee, Jin Gu, Lee, Chang Young, Bae, Mi Kyung, Chung, Kyung Young, Jung, Ji Ye, Kim, Eun Young, Kim, Se Kyu, Chang, Joon, Kim, Hye Ryun, Kim, Joo Hang, Lee, Min Goo, Cho, Byoung Chul, Lee, Ji Hyun, Bang, Duhee“…CONCLUSIONS: The genomic makeup of EGFR/KRAS/ALK-negative lung adenocarcinomas in never-smokers is remarkably diverse. Genes involved in cell cycle regulation/DNA repair are implicated in tumorigenesis and represent potential therapeutic targets.…”
Publicado 2014
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460“…An alternative strategy targets gene mutations that are never observed. Because up or down regulation of these genes unconditionally reduces cellular fitness, they are eliminated by evolutionary triage but can be exploited for targeted therapy.…”
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