“…Better understanding of these events will no doubt provide new approaches for biomarkers of diagnosis and effective therapeutic targeting of gastric cancer.…”
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“…We should control the wound closure with suture when in doubt.…”
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“…TNF inhibitors are currently considered both effective and cost-effective in patients with active rheumatoid arthritis (RA), particularly in patients who have not responded fully to methotrexate. There is substantial doubt about the cost-effectiveness of TNF inhibitors as initial treatment for active RA. …”
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“…In view of these disagreements, our proposal is to distinguish epithelial hyperplasia, lobular carcinoma in situ and ductal carcinoma in situ, and to abandon the use of poorly reproducible categories, such as atypical ductal hyperplasia or ductal intraepithelial neoplasia, followed by a number to indicate the degree of proliferation and atypia, as these are not practical for clinical decision making, nor for studies aimed at improving the understanding of breast cancer development. If there is doubt about the classification of an intraductal proliferation, a differential diagnosis and the reason for and degree of uncertainty should be given, rather than categorizing a proliferation as atypical.…”
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“…The purpose of this article is to remove the myths and black art surrounding electronic imaging and prove beyond doubt that any mind competent in the workings of the human body is capable of producing good on-screen images from adequate equipment. …”
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“…While evidence for causality remains elusive, there is no doubt that patients who develop delirium are left with new functional and cognitive impairment. …”
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“…Early in his life there is no doubt that he suffered from a series of infective diseases which were common in 18th century Europe, and died of an acute epidemic illness. …”
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“…Reviews of previous editions have characterized it as "an essential source of psychoacoustic knowledge," "a major landmark ," and a book that "without doubt will have a long-lasting effect on the standing and future evolution of this scientific domain."…”
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“…Many commentators however doubt the scientific rigor of these forecasts, rejecting them as speculative and unfounded. …”
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“…This volume presents the work of leading scientists from Russia, Georgia, Estonia, Lithuania, Israel, and the USA, revealing major insights long unknown to the scientific community. Without any doubt their work will provide a springboard for further research in anticipation. …”
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“…Whether you consider “IoT” as a real thing or a buzzword, there’s no doubt that connected devices, data analysis and automation are transforming industry. …”
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“…However, amplification of the cognate gene is observed rarely, leaving the responsible mechanism(s) and its importance in tumorigenesis in doubt. In a recent report, Steve Reed's lab demonstrates that hCdc4/Fbw7 targets cyclin E for ubiquitin-mediated proteolysis and is mutant in a breast cancer cell line with high cyclin E levels. …”
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“…Ultraviolet absorption spectra, pK values of the phenol group, solubility measurements, and partition coefficients were so nearly identical for the two materials that there is now no reason to doubt that the product from pepsin is 3-iodotyrosine.…”
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“…Although the action of TGFβ as a canonical tumor suppressor in breast is without a doubt, there is compelling evidence that TGFβ is frequently subverted in a malignant plexus that drives breast cancer. …”
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“…Two frequently applied genetic Bacteroidetes markers for total fecal pollution (AllBac and BacUni) were found in high numbers in pristine soil samples of two alpine catchment areas casting doubt on their value as fecal indicators. This finding underlines the necessity to evaluate assays locally and against non-intestinal samples before application.…”
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“…The present method is no doubt an improvised procedure for estimating directly caffeine content from the tea extracts. …”
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“…Data from recent studies cast doubt on former recommendations on diagnosis and management of Barrett’s esophagus. …”
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“…Another study casts doubt on the value of early treatment and treatment interruptions. …”
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“…Implant option for surgical management is also in doubt. We would like to share our experience in treating a patient with bilateral clavicle fracture surgically. …”
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