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  1. 421
    por Drumm, Mitchell L
    Publicado 2001
    “…In the meantime, while thousands of polymorphisms are cataloged and other genomic resources become more available, the number of association studies with candidate genes will no doubt increase. To make sense of these studies, the choice of gene and phenotype must be carefully considered.…”
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    Modifier genes and variation in cystic fibrosis
  2. 422
    por Cameron, D. A.
    Publicado 1961
    “…The arrangement of the cell organelles does not seem to be related to the formation of collagen, but correlation of the fine structures of the cells with the histochemical and cytochemical findings in these cells reported by other workers leaves no doubt that they are directly concerned in the production of the organic matrix. …”
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    THE FINE STRUCTURE OF OSTEOBLASTS IN THE METAPHYSIS OF THE TIBIA OF THE YOUNG RAT
  3. 423
    por Esiri, Margaret M
    Publicado 2010
    “…Recent advances in the clinical diagnostic instruments for diagnosing Alzheimer's disease (AD) and in neuroimaging may cast doubt in the minds of some practitioners about the continued need for neuropathology to provide the ultimate diagnosis. …”
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    Pro: Can neuropathology really confirm the exact diagnosis?
  4. 424
    “…After completion of the “human genome project” and with the availability of high-resolution genotyping, genetic susceptibility to hypersensitivity for certain drugs has been proved beyond doubt though the trend is ethnicity and phenotype dependent. …”
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    CUTANEOUS DRUG HYPERSENSITIVITY: IMMUNOLOGICAL AND GENETIC PERSPECTIVE
  5. 425
    “…The role of silver additives is examined in the context of gold-mediated functionalisation of aromatic C–H bonds. Doubt is cast on the commonly cited route of halide abstraction from gold and evidence of substrate activation is given.…”
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    The role of silver additives in gold-mediated C–H functionalisation
  6. 426
    por Klimesch, Wolfgang
    Publicado 2012
    “…Nonetheless, there is little doubt that alpha-band oscillations also play an active role in information processing. …”
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    Alpha-band oscillations, attention, and controlled access to stored information
  7. 427
    “…Our analysis thus casts doubt on the degree to which quantum discord is necessary for ghost imaging.…”
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    Ghost Imaging without Discord
  8. 428
    “…Nonexercise activity thermogenesis (NEAT) and physical activity, that is crucial for weight control, may be important in the physiology of weight change. An intriguing doubt that remains unresolved is whether changes in nutrient intake or body composition secondarily affect the spontaneous physical activity.…”
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    Physical Activity: An Important Adaptative Mechanism for Body-Weight Control
  9. 429
    “…People over 75 years of age represent a specific group of patients for which the clinician is often in doubt about what to do, whether additional diagnostic workup is helpful or a primary medical approach would suffice. …”
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    Coronary CT angiography in the elderly
  10. 430
    “…Conclusions: Although the usefulness of the microvascular anastomotic coupler in microsurgical flap reconstruction is not in doubt, as described previously, we believe that it is necessary to remember that use of a microvascular anastomotic coupler involves potential risks of exposure and anastomosed vessel disruption.…”
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    Exposure of a Microvascular Anastomotic Coupler in Head and Neck Reconstruction: A Case Report
  11. 431
    por Bae, Jong-Myon
    Publicado 2014
    “…However, the curves of incidence by age group cast doubt on the birth cohort effect hypothesis. To explain the curves, here I suggest two alternative hypotheses of breast density and viral infection based on pre-existing evidences. …”
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    Two hypotheses of dense breasts and viral infection for explaining incidence of breast cancer by age group in Korean women
  12. 432
    “…Venous thromboembolism at lower age groups and in the absence of other known risk factors should raise doubt of underlying genetic disorders and thombophilia. …”
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    Cavernous Sinus and Generalized Venous Thrombosis Following Rhinoplasty in a Young Patient
  13. 433
    “…Although some authors doubt the existence of the paraneoplastic Leser-Trélat syndrome, we present a case of sudden eruption of seborrheic keratoses connected with a newly diagnosed renal cell carcinoma. …”
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    A Case of Leser-Trélat Syndrome Associated with a Renal Cell Carcinoma
  14. 434
    por Artlett, Carol M
    Publicado 2014
    “…Without doubt, animal models have provided significant insights into our understanding of the rheumatological diseases; however, no model has accurately replicated all aspects of any autoimmune disease. …”
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    Animal models of systemic sclerosis: their utility and limitations
  15. 435
    por Benn, Christine Stabell
    Publicado 2017
    “…The justification for using VAS is to reduce child mortality, but there is now doubt that VAS has any effect on overall child mortality. …”
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    We Need Studies of the Mortality Effect of Vitamin A Supplementation, Not Surveys of Vitamin A Deficiency
  16. 436
    “…Imaging techniques, in particular Ultrasound, play a key role in case of diagnostic doubt, especially when the hernia occurs in a context of oscillating testicles because this may mimic a torsion of the spermatic cord. …”
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    Hernie inguinale étranglée compliquée d’ischémie testiculaire sur perméabilité du canal peritonéo-vaginal
  17. 437
    “…The RNA-to-cDNA conversion step in transcriptomics experiments is widely recognised as inefficient and variable, casting doubt on the ability to do quantitative transcriptomics analyses. …”
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    Shedding light: The importance of reverse transcription efficiency standards in data interpretation
  18. 438
    por Melchior, Guido
    Publicado 2020
    “…I will argue that when we doubt the reliability of a source, bootstrapping is not a persuasive method for coming to believe that the source is reliable. …”
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    The persuasiveness puzzle about bootstrapping
  19. 439
    “…The absolute configurations of the natural products (+)-cycloillicinone and (−)-illicarborene A have been determined, and our results cast doubt on the enantiopurity of the natural samples.…”
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    Enantioselective para-Claisen Rearrangement for the Synthesis of Illicium-Derived Prenylated Phenylpropanoids
  20. 440
    por Norris, Dennis, Cutler, Anne
    Publicado 2021
    “…Cognition, this journal, came into being some 45 years ago as an attempt to lay one such period to rest; without doubt, it has helped create the current cognitive science climate in which theory is decidedly welcome. …”
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    More why, less how: What we need from models of cognition()
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