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  1. 681
    “…These advances have increased the number and utility of medical devices available to the anesthesiologist. There is little doubt that these new tools have improved the practice of anesthesia. …”
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    Medical devices for the anesthetist: current perspectives
  2. 682
    por Gardner, David M
    Publicado 2014
    “…There is little doubt that undergraduate and post-graduate training of physicians, pharmacists, and nurses is insufficient to prepare them to use psychotropics safely and effectively, especially in the context of their expanded off-label uses. …”
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    Competent Psychopharmacology
  3. 683
    por Weigl, Peter D, Knowles, Travis W
    Publicado 2014
    “…The origin and persistence of these landscapes have been the focus of such controversy that in many areas their conservation is in doubt. In the USA some biologists have largely dismissed the grass balds of the Southern Appalachians as human artifacts or anomalous and transitory elements of regional geography, worthy of only limited preservation efforts. …”
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    Temperate mountain grasslands: a climate-herbivore hypothesis for origins and persistence
  4. 684
    “…Although Penile Mondor’s disease is typically a clinical diagnosis, Doppler ultrasound is the initial imaging modality of choice if there is question or doubt about the diagnosis. Accurate diagnosis and reassurance about the condition’s benign and self-limiting nature assuages most patients’ fears. …”
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    A common presentation to an uncommon disease. Penile Mondor’s disease: a case report and literature review
  5. 685
    por Boag, Simon
    Publicado 2011
    “…However, certain conceptual and logical issues cast doubt upon the adequacy of traits as coherent explanatory constructs. …”
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    Explanation in personality psychology: “Verbal magic” and the five-factor model
  6. 686
    por Singer, Richard F.
    Publicado 2011
    “…This series suggests high doses of cholecalciferol over a prolonged period of time are necessary to achieve recommended calcidiol levels; however, the lack of an impact on PTH casts doubt on the suitability of the calcidiol target, in patients with heavy proteinuria.…”
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    Long-term high-dose cholecalciferol in patients with heavy proteinuria
  7. 687
    por Simberloff, Daniel
    Publicado 2015
    “…Amidst this research progress, a group of critics has attempted to cast doubt on the extent of damaging impacts caused by non-native invasive species, the feasibility of counteracting them and restoring ecosystems, and the motives of scientists engaged in such endeavors. …”
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    Non-native invasive species and novel ecosystems
  8. 688
    “…The good news is that existing and emerging technology and treatment planning systems as will without doubt lead in the forthcoming future to practical solutions to tackle intra-fraction motion in proton therapy. …”
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    Tumour Movement in Proton Therapy: Solutions and Remaining Questions: A Review
  9. 689
    “…One additional and, without doubt, highly impressive aspect is the recently identified key function of selected nuclear envelope components in driving meiotic chromosome dynamics, which in turn is essential for accurate recombination and segregation of the homologous chromosomes. …”
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    Structural and functional adaptations of the mammalian nuclear envelope to meet the meiotic requirements
  10. 690
    “…These findings create doubt about the interpretation of data on prostaglandin biosynthesis in intrauterine tissues from pregnant women especially in the presence of an infection. …”
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    Differential Regulation of Eicosanoid and Endocannabinoid Production by Inflammatory Mediators in Human Choriodecidua
  11. 691
    por Ikehara, Kenji
    Publicado 2016
    “…It is no doubt quite difficult to solve the riddle of the origin of life. …”
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    Evolutionary Steps in the Emergence of Life Deduced from the Bottom-Up Approach and GADV Hypothesis (Top-Down Approach)
  12. 692
    por Middleton, Hugh
    Publicado 2016
    “…This framework challenges conventional healthcare policies and practices, but in ways that offer insights into how patient-centred approaches to chronic illness and disability might be better conceived and enabled. It also throws into doubt the rectitude of an economic model built around services and products designed to provide easy access to sources of immediate gratification.…”
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    Flourishing and Posttraumatic Growth. An Empirical Take on Ancient Wisdoms
  13. 693
    “…The clinician should be aware of all the possible pathological etiologies of white lesions. If there is any doubt about the nature or management of a usual oral lesion, a referral to an appropriate specialist is mandatory.…”
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    Lichenoid reaction associated with silver amalgam restoration in a Bombay blood group patient: A case report
  14. 694
    “…The vascular smooth muscle cells have an extraordinary capacity to undergo osteoblastic phenotypical differentiation. There is no doubt that the role of these factors, as well as the elements of genomics and proteomics, could be a vital strategic point in prevention and treatment. …”
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    Vascular calcification: pathophysiology and clinical implications
  15. 695
    por Slovin, Susan F
    Publicado 2013
    “…While melanoma is leading the field towards these ends, there is some doubt that not all of the recent successes with immune therapies, for example, checkpoint inhibitors, will be effective for every cancer, and that the toxicities may also be different depending on the malignancy. …”
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    Emerging treatments in management of prostate cancer: biomarker validation and endpoints for immunotherapy clinical trial design
  16. 696
    “…The latest studies using metagenomic methods are casting doubt on the assumption of microbial equivalence between periodontal and peri-implant crevices. …”
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    Peri-implant disease: what we know and what we need to know
  17. 697
    por Kumazaki, Tsutomu
    Publicado 2013
    “…Thus, this paper casts doubt on the common opinion that Jaspers was under the profound influence of Husserl or Dilthey.…”
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    The theoretical root of Karl Jaspers’ General Psychopathology. Part 1: Reconsidering the influence of phenomenology and hermeneutics
  18. 698
    por Stencel, Adrian
    Publicado 2016
    “…If there is a single discipline of science calling the basic concepts of biology into question, it is without doubt microbiology. Indeed, developments in microbiology have recently forced us to rethink such fundamental concepts as the organism, individual, and genome. …”
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    The relativity of Darwinian populations and the ecology of endosymbiosis
  19. 699
    por Fisher, Robert P.
    Publicado 2016
    “…Recent work has revealed molecular mechanisms underlying this decision-making process in both yeast and mammalian cells but also cast doubt on the nature and timing of cell-cycle commitment in multicellular organisms. …”
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    Getting to S: CDK functions and targets on the path to cell-cycle commitment
  20. 700
    “…Due to the extremely short sequence and the high variability in both sequence and structure, no unambiguous candidates were found. These results cast doubt on putative U7 homologs in even more distant organisms that are reported in the most recent release of the Rfam database.…”
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    U7 snRNAs: A Computational Survey
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