“…Objectives: There are limited data on head-to-head comparative risk of stroke between sodium-glucose cotransporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA). …”
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“…Early initiation of glucagon-like peptide-1 receptor agonist (GLP-1 RA) therapy is associated with improved glycemic outcomes among people with type 2 diabetes (T2D). However, there is limited real-world evidence suggesting a similar impact on weight reduction. …”
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“…Germline variants (GVs) in patients with ACC have been identified mainly in pediatric patients and in family cases, while data on GVs in adult patients with sporadic ACC are limited. Methods: We analyzed germline DNA from 150 adult patients with sporadic ACC sequentially referred to our centers between 1998 and 2019. …”
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“…To overcome such a limitation, existing researchers need to conduct collaborative joint planning and research centered on particular themes through cooperation. …”
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“…AIMS: Limited real-world data show that rivaroxaban following dosage criteria from either ROCKET AF [20 mg/day or 15 mg/day if creatinine clearance (CrCl) < 50 mL/min] or J-ROCKET AF (15 mg/day or 10 mg/day if CrCl < 50 mL/min) is associated with comparable risks of thromboembolism and bleeding with each other in patients with non-valvular atrial fibrillation (NVAF). …”
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“…However, evidence on this syndrome related to individual antidepressants is limited, as well as about individual risk factors for severe reactions. …”
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“…This difference, although not statistically significant due to the limited patient number in this study, suggests that quantitative assessment of HER2-targeted PET/CT can be used for accurate response evaluation after NAT. …”
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“…Kaplan-Meir analysis was utilized to determine the association of 5hmC signatures with progression-free survival. RESULTS AND LIMITATIONS: 5hmC-sequencing generated an average of 18.6 (range 6.03 to 42.43) million reads per sample with 98% (95–99%) mappable rate. …”
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“…Multivariable logistic regression revealed that only moderate/high stress with motherhood/children (adjusted odds ratio (OR) 3.31, 95% CI 1.60–6.85) and history of infertility (adjusted OR 9.67, 95% CI 5.02–18.64) were significantly associated with active pregnancy planning in women with PCOS. LIMITATIONS, REASONS FOR CAUTION: The findings were based on self-reported data. …”
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“…Regarding patient’s baseline tests, we found certain markers could help predict final engraftment success: for lactate dehydrogenase (LDH) levels, 34.1% (140/411) of tumors derived from patients with baseline blood LDH levels above the upper limit of normality (ULN) achieved growth, against 30.7% (47/153) with normal LDH (p = 0.047). …”
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“…In addition, we aim to identify and discuss the main gaps, challenges, and limitations in the current research on VR exergaming for CP rehabilitation. …”
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“…BACKGROUND: Isavuconazole (ISC) is considered first-line therapy for the treatment of invasive aspergillosis (IA). There is limited data on antifungal susceptibility testing of clinically relevant non-fumigatus (non-AFM) and cryptic species of Aspergillus (cryAsp) causing IA. …”
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“…Annual influenza vaccination is recommended for all children ≥ 6 months and can protect against severe influenza. Limited studies have examined if vaccine effectiveness (VE) against influenza illness differs in children with underlying conditions compared to those without. …”
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“…. **: p = 0.0022, ns = not significant, tested via Mann-Whitney U-test. L. o. D., limit of detection. VE707_LBP = VE707 produced via monoculture of each strain in the consortia. …”
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“…BACKGROUND: Predicting, preventing, and treating post-COVID condition (PCC; “Long COVID) is challenging due to a limited understanding of PCC mechanisms. To address this, we analyzed whole blood transcriptomic data using machine learning to identify candidate gene and gene expression pathways associated with the development of PCC. …”
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“…The activity of recently approved BLIs varied broadly among regions and were very limited in E-EU and APAC. DISCLOSURES: Helio S. Sader, MD, PhD, FIDSA, AbbVie: Grant/Research Support|Basilea: Grant/Research Support|Cipla: Grant/Research Support|Paratek: Grant/Research Support|Pfizer: Grant/Research Support|Shionogi: Grant/Research Support Mariana Castanheira, PhD, AbbVie: Grant/Research Support|Basilea: Grant/Research Support|bioMerieux: Grant/Research Support|Cipla: Grant/Research Support|CorMedix: Grant/Research Support|Entasis: Grant/Research Support|Melinta: Grant/Research Support|Paratek: Grant/Research Support|Pfizer: Grant/Research Support|Shionogi: Grant/Research Support Leonard R. …”
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“…BACKGROUND: Treatment options for mucocutaneous herpes simplex virus infections (HSV) refractory or resistant (r/r) to acyclovir (ACV) are limited. High-dose ACV continuous infusion, foscarnet (FCN), cidofovir (CDV), and/or topical agents have been used. …”
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“…BACKGROUND: There is growing evidence that people with tuberculosis (TB) are at higher risk of mortality even after treatment completion. However, there are limited data on post-TB treatment mortality rates and causes of death in the United States (U.S.). …”
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“…BACKGROUND: Limited data exist worldwide regarding the genetic epidemiology of mixed G and/or P Rotavirus group A (RVA) strains and their association with demographic and clinical characteristics in children with acute gastroenteritis (AGE). …”
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“…The distribution of variants among these cases were as follows: 39 Alpha (6.6%), 2 Beta (0.3%), 307 Delta (51.9%), 9 Gamma (1.5%), 5 Mu (0.8%), and 230 Omicron (38.9%). When analysis was limited to participants with Alpha, Delta, or Omicron, those with Omicron were significantly older, white, female, and had underlying comorbidities. …”
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