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  1. 702721
    por Berndt, Sonja I., Camp, Nicola J., Skibola, Christine F., Vijai, Joseph, Wang, Zhaoming, Gu, Jian, Nieters, Alexandra, Kelly, Rachel S., Smedby, Karin E., Monnereau, Alain, Cozen, Wendy, Cox, Angela, Wang, Sophia S., Lan, Qing, Teras, Lauren R., Machado, Moara, Yeager, Meredith, Brooks-Wilson, Angela R., Hartge, Patricia, Purdue, Mark P., Birmann, Brenda M., Vajdic, Claire M., Cocco, Pierluigi, Zhang, Yawei, Giles, Graham G., Zeleniuch-Jacquotte, Anne, Lawrence, Charles, Montalvan, Rebecca, Burdett, Laurie, Hutchinson, Amy, Ye, Yuanqing, Call, Timothy G., Shanafelt, Tait D., Novak, Anne J., Kay, Neil E., Liebow, Mark, Cunningham, Julie M., Allmer, Cristine, Hjalgrim, Henrik, Adami, Hans-Olov, Melbye, Mads, Glimelius, Bengt, Chang, Ellen T., Glenn, Martha, Curtin, Karen, Cannon-Albright, Lisa A., Diver, W Ryan, Link, Brian K., Weiner, George J., Conde, Lucia, Bracci, Paige M., Riby, Jacques, Arnett, Donna K., Zhi, Degui, Leach, Justin M., Holly, Elizabeth A., Jackson, Rebecca D., Tinker, Lesley F., Benavente, Yolanda, Sala, Núria, Casabonne, Delphine, Becker, Nikolaus, Boffetta, Paolo, Brennan, Paul, Foretova, Lenka, Maynadie, Marc, McKay, James, Staines, Anthony, Chaffee, Kari G., Achenbach, Sara J., Vachon, Celine M., Goldin, Lynn R., Strom, Sara S., Leis, Jose F., Weinberg, J. Brice, Caporaso, Neil E., Norman, Aaron D., De Roos, Anneclaire J., Morton, Lindsay M., Severson, Richard K., Riboli, Elio, Vineis, Paolo, Kaaks, Rudolph, Masala, Giovanna, Weiderpass, Elisabete, Chirlaque, María- Dolores, Vermeulen, Roel C. H., Travis, Ruth C., Southey, Melissa C., Milne, Roger L., Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Clavel, Jacqueline, Zheng, Tongzhang, Holford, Theodore R., Villano, Danylo J., Maria, Ann, Spinelli, John J., Gascoyne, Randy D., Connors, Joseph M., Bertrand, Kimberly A., Giovannucci, Edward, Kraft, Peter, Kricker, Anne, Turner, Jenny, Ennas, Maria Grazia, Ferri, Giovanni M., Miligi, Lucia, Liang, Liming, Ma, Baoshan, Huang, Jinyan, Crouch, Simon, Park, Ju-Hyun, Chatterjee, Nilanjan, North, Kari E., Snowden, John A., Wright, Josh, Fraumeni, Joseph F., Offit, Kenneth, Wu, Xifeng, de Sanjose, Silvia, Cerhan, James R., Chanock, Stephen J., Rothman, Nathaniel, Slager, Susan L.
    Publicado 2016
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    Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia
  2. 702722
    por Fan, Qiao, Verhoeven, Virginie J. M., Wojciechowski, Robert, Barathi, Veluchamy A., Hysi, Pirro G., Guggenheim, Jeremy A., Höhn, René, Vitart, Veronique, Khawaja, Anthony P., Yamashiro, Kenji, Hosseini, S Mohsen, Lehtimäki, Terho, Lu, Yi, Haller, Toomas, Xie, Jing, Delcourt, Cécile, Pirastu, Mario, Wedenoja, Juho, Gharahkhani, Puya, Venturini, Cristina, Miyake, Masahiro, Hewitt, Alex W., Guo, Xiaobo, Mazur, Johanna, Huffman, Jenifer E., Williams, Katie M., Polasek, Ozren, Campbell, Harry, Rudan, Igor, Vatavuk, Zoran, Wilson, James F., Joshi, Peter K., McMahon, George, St Pourcain, Beate, Evans, David M., Simpson, Claire L., Schwantes-An, Tae-Hwi, Igo, Robert P., Mirshahi, Alireza, Cougnard-Gregoire, Audrey, Bellenguez, Céline, Blettner, Maria, Raitakari, Olli, Kähönen, Mika, Seppala, Ilkka, Zeller, Tanja, Meitinger, Thomas, Ried, Janina S., Gieger, Christian, Portas, Laura, van Leeuwen, Elisabeth M., Amin, Najaf, Uitterlinden, André G., Rivadeneira, Fernando, Hofman, Albert, Vingerling, Johannes R., Wang, Ya Xing, Wang, Xu, Tai-Hui Boh, Eileen, Ikram, M. Kamran, Sabanayagam, Charumathi, Gupta, Preeti, Tan, Vincent, Zhou, Lei, Ho, Candice E. H., Lim, Wan'e, Beuerman, Roger W., Siantar, Rosalynn, Tai, E-Shyong, Vithana, Eranga, Mihailov, Evelin, Khor, Chiea-Chuen, Hayward, Caroline, Luben, Robert N., Foster, Paul J., Klein, Barbara E. K., Klein, Ronald, Wong, Hoi-Suen, Mitchell, Paul, Metspalu, Andres, Aung, Tin, Young, Terri L., He, Mingguang, Pärssinen, Olavi, van Duijn, Cornelia M., Jin Wang, Jie, Williams, Cathy, Jonas, Jost B., Teo, Yik-Ying, Mackey, David A., Oexle, Konrad, Yoshimura, Nagahisa, Paterson, Andrew D., Pfeiffer, Norbert, Wong, Tien-Yin, Baird, Paul N., Stambolian, Dwight, Wilson, Joan E. Bailey, Cheng, Ching-Yu, Hammond, Christopher J., Klaver, Caroline C. W., Saw, Seang-Mei, Rahi, Jugnoo S., Korobelnik, Jean-François, Kemp, John P., Timpson, Nicholas J., Smith, George Davey, Craig, Jamie E., Burdon, Kathryn P., Fogarty, Rhys D., Iyengar, Sudha K., Chew, Emily, Janmahasatian, Sarayut, Martin, Nicholas G., MacGregor, Stuart, Xu, Liang, Schache, Maria, Nangia, Vinay, Panda-Jonas, Songhomitra, Wright, Alan F., Fondran, Jeremy R., Lass, Jonathan H., Feng, Sheng, Zhao, Jing Hua, Khaw, Kay-Tee, Wareham, Nick J., Rantanen, Taina, Kaprio, Jaakko, Pang, Chi Pui, Chen, Li Jia, Tam, Pancy O., Jhanji, Vishal, Young, Alvin L., Döring, Angela, Raffel, Leslie J., Cotch, Mary-Frances, Li, Xiaohui, Yip, Shea Ping, Yap, Maurice K.H., Biino, Ginevra, Vaccargiu, Simona, Fossarello, Maurizio, Fleck, Brian, Yazar, Seyhan, Tideman, Jan Willem L., Tedja, Milly, Deangelis, Margaret M., Morrison, Margaux, Farrer, Lindsay, Zhou, Xiangtian, Chen, Wei, Mizuki, Nobuhisa, Meguro, Akira, Mäkelä, Kari Matti
    Publicado 2016
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    Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
  3. 702723
    por Yang, Guosheng, Qiu, Xiaofo
    Publicado 2016
    “…(i) Efficacy of the lithotripsy: group RIRS of patients with calculi one-time clearance rate was 87.5% (35/40), two cases of renal calyx calculi patients need DURL and had a successful treatment, one case of renal calyx diverticulum for the flexible ureteroscope rotation angle limit had failed to lithotripsy. The total clearance rate of renal calculi was 97.5% (39/40); group PCNL of patients with calculi one-time clearance rate was 85% (34/40), two cases of patients after the 2(nd) phase PCNL succeed, two cases with residual stone more than 2 mm. …”
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    AB199. Investigation of flexible ureteroscope and percutaneous nephrolithotomy in treatment of renal calculi (1–2 cm) on the effects of inflammatory reaction
  4. 702724
    “…Spermatozoa with electrophysiological abnormities (conductance and V(m)) responded normally to progesterone with elevation of [Ca(2+)](i) and penetration of viscous medium, indicating retention of cation channel of sperm (CatSper) channel function. LIMITATIONS, REASONS FOR CAUTION: For practical, technical, ethical and logistical reasons, we could not obtain sufficient additional semen samples from men with conductance abnormalities to establish the cause of the conductance defects. …”
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    Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF
  5. 702725
    “…CONCLUSIONS: Even if both ICS/LABA combinations were checked over a limited period of time, they seem characterized by a different profile in terms of effect on lung function and economic impact on mild-to-moderate asthma. …”
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    Fluticasone furoate/Vilanterol 92/22 μg once-a-day vs Beclomethasone dipropionate/ Formoterol 100/6 μg b.i.d.: a 12-week cost analysis in mild-to-moderate asthma
  6. 702726
    “…AUTHORS' CONCLUSIONS: Iron treatment does not increase the risk of clinical malaria when regular malaria prevention or management services are provided. Where resources are limited, iron can be administered without screening for anaemia or for iron deficiency, as long as malaria prevention or management services are provided efficiently. 12 April 2019 No update planned Other There is high‐certainty evidence that oral iron supplements do not adversely affect children living in malaria‐endemic areas, meaning further research is unlikely to change our confidence in the estimate of effect. …”
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    Oral iron supplements for children in malaria‐endemic areas
  7. 702727
    “…In an external cohort, the new system achieved a concordance index of 0.79 (95% CI 0.75–0.84) for predicting PCSM versus 0.66 (95% CI 0.63–0.69) (p < 0.0001) for the current NICE risk stratification system. The main limitations of the study were that it was registry based and that follow-up was relatively short. …”
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    Improving Clinical Risk Stratification at Diagnosis in Primary Prostate Cancer: A Prognostic Modelling Study
  8. 702728
    “…As atrial fibrillation and a rapid heart rate have been closely linked to mortality, detection of atrial fibrillation should be considered systematically.The limited use of nitrates in DeFSSICA may be related to the median SBP of 140 (121–160) mmHg. …”
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    Management of suspected acute heart failure dyspnea in the emergency department: results from the French prospective multicenter DeFSSICA survey
  9. 702729
    “…No serious adverse effects were recorded during study follow-up. The key study limitation was that only a single infant sample was collected to minimize venipunctures for the children. …”
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    Pre-exposure Prophylaxis Use by Breastfeeding HIV-Uninfected Women: A Prospective Short-Term Study of Antiretroviral Excretion in Breast Milk and Infant Absorption
  10. 702730
    “…When prepubertal ovaries were treated with SN38, no effect was seen on germ cell number, apoptosis or cell proliferation, even after exposure to the highest drug concentrations. LIMITATIONS REASONS FOR CAUTION: As with any study using in vitro experiments with an experimental animal model, caution is required when extrapolating the present findings to humans. …”
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    Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice
  11. 702731
    “…While a single parameter is of limited value for calculating the target age of 18 years, combining several findings, that can be determined on a standard radiography, may potentially be a more reliable diagnostic tool for estimating the target age in both sexes. …”
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    Predictive values derived from lower wisdom teeth developmental stages on orthopantomograms to calculate the chronological age in adolescence and young adults as a prerequisite to obtain age-adjusted informed patient consent prior to elective surgical procedures in young patients with incomplete or mismatched personal data
  12. 702732
    “…In addition, the proportions of overweight (or obese) patients and patients suffering from a chronic disease were significantly increased in almost all of the patient subgroups. LIMITATIONS REASONS FOR CAUTION: The study included only subjects with reduced total spermatozoa counts. …”
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    Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts
  13. 702733
    “…Therefore, combining these inhibitors with steroid treatment may enhance steroid sensitivity in patients with ALL. The main limitation of our study was the modest cohort size, owing to the very low incidence of T-ALL. …”
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    IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study
  14. 702734
    “…Lastly, higher lean mass does appear to benefit sprint skiers’ performance, with no clear advantage conferred via body height and mass. LIMITATIONS: Generalization of findings from one study to the next is challenging considering the array of experimental tasks, variables defining performance, fundamental differences between skiing techniques, and evolution of sprint skiing competitions. …”
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    Factors that Influence the Performance of Elite Sprint Cross-Country Skiers
  15. 702735
    “…BACKGROUND: The industrial workhorse fungus, Trichoderma reesei, is typically exploited for its ability to produce cellulase enzymes, whereas use of this fungus for over-expression of other proteins (homologous and heterologous) is still very limited. Identifying transformants expressing target protein is a tedious task due to low transformation efficiency, combined with highly variable expression levels between transformants. …”
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    A versatile 2A peptide-based bicistronic protein expressing platform for the industrial cellulase producing fungus, Trichoderma reesei
  16. 702736
    “…The toxic elements were found to be within the permissible limit. Glutamic acid (19.37%), glycine (14.53%) and lysine (17.08%) were found as the major amino acids. …”
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    Chemical composition and pharmacological significance of Anethum Sowa L. Root
  17. 702737
    “…Controlling for sex, maternal genotype, and indices of socioeconomic adversity (housing, employment, education, electricity, water) did not change these results. A limitation of this study is that we were only able to reenroll 49% of the original sample randomized to the intervention and control conditions. …”
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    Serotonin transporter gene (SLC6A4) polymorphism and susceptibility to a home-visiting maternal-infant attachment intervention delivered by community health workers in South Africa: Reanalysis of a randomized controlled trial
  18. 702738
    “…FUNDING: Cancer Research UK, MRC Clinical Trials Unit at University College London, and F Hoffmann-La Roche Limited.…”
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    Peri-operative chemotherapy with or without bevacizumab in operable oesophagogastric adenocarcinoma (UK Medical Research Council ST03): primary analysis results of a multicentre, open-label, randomised phase 2–3 trial
  19. 702739
    “…INTERPRETATION: Despite the limitations imposed by the suspension of the HPV vaccination, our findings lend support to the WHO recommendation of two doses, at least 6 months apart, for routine vaccination of young girls. …”
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    Immunogenicity and HPV infection after one, two, and three doses of quadrivalent HPV vaccine in girls in India: a multicentre prospective cohort study
  20. 702740
    “…In a subset of the same cohort, dose of DR15 was also associated with higher baseline levels of chemokine CC-4, a biomarker of inflammation (p = 0.005, β ± standard error = 0.08 ± 0.03). The main study limitations are that the results represent only individuals of European-ancestry and clinically diagnosed individuals, and that our study used imputed genotypes for a subset of HLA genes. …”
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    Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study
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