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  1. 703121
    por Pfeffer, Daniel A., Ley, Benedikt, Howes, Rosalind E., Adu, Patrick, Alam, Mohammad Shafiul, Bansil, Pooja, Boum, Yap, Brito, Marcelo, Charoenkwan, Pimlak, Clements, Archie, Cui, Liwang, Deng, Zeshuai, Egesie, Ochaka Julie, Espino, Fe Esperanza, von Fricken, Michael E., Hamid, Muzamil Mahdi Abdel, He, Yongshu, Henriques, Gisela, Khan, Wasif Ali, Khim, Nimol, Kim, Saorin, Lacerda, Marcus, Lon, Chanthap, Mekuria, Asrat Hailu, Menard, Didier, Monteiro, Wuelton, Nosten, François, Oo, Nwe Nwe, Pal, Sampa, Palasuwan, Duangdao, Parikh, Sunil, Pitaloka Pasaribu, Ayodhia, Poespoprodjo, Jeanne Rini, Price, David J., Roca-Feltrer, Arantxa, Roh, Michelle E., Saunders, David L., Spring, Michele D., Sutanto, Inge, Ley-Thriemer, Kamala, Weppelmann, Thomas A., von Seidlein, Lorenz, Satyagraha, Ari Winasti, Bancone, Germana, Domingo, Gonzalo J., Price, Ric N.
    Publicado 2020
    “…Our ability to identify underlying factors associated with study-level heterogeneity was limited by the lack of availability of covariate data and diverse study contexts and methodologies. …”
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    Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis
  2. 703122
    “…Capacity for acute diagnosis via PCR testing was limited for individuals with mild to moderate SARS-CoV-2 infection in the early phase of the COVID-19 pandemic and a substantial proportion of health-care workers with suspected infection were not tested. …”
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    Point-of-care serological assays for delayed SARS-CoV-2 case identification among health-care workers in the UK: a prospective multicentre cohort study
  3. 703123
    por Hossain, Mohammad S., Commons, Robert J., Douglas, Nicholas M., Thriemer, Kamala, Alemayehu, Bereket H., Amaratunga, Chanaki, Anvikar, Anupkumar R., Ashley, Elizabeth A., Asih, Puji B. S., Carrara, Verena I., Lon, Chanthap, D’Alessandro, Umberto, Davis, Timothy M. E., Dondorp, Arjen M., Edstein, Michael D., Fairhurst, Rick M., Ferreira, Marcelo U., Hwang, Jimee, Janssens, Bart, Karunajeewa, Harin, Kiechel, Jean R., Ladeia-Andrade, Simone, Laman, Moses, Mayxay, Mayfong, McGready, Rose, Moore, Brioni R., Mueller, Ivo, Newton, Paul N., Thuy-Nhien, Nguyen T., Noedl, Harald, Nosten, Francois, Phyo, Aung P., Poespoprodjo, Jeanne R., Saunders, David L., Smithuis, Frank, Spring, Michele D., Stepniewska, Kasia, Suon, Seila, Suputtamongkol, Yupin, Syafruddin, Din, Tran, Hien T., Valecha, Neena, Van Herp, Michel, Van Vugt, Michele, White, Nicholas J., Guerin, Philippe J., Simpson, Julie A., Price, Ric N.
    Publicado 2020
    “…In multivariable analyses, the highest rate of P. vivax parasitaemia over 42 days of follow-up was in patients residing in areas of short relapse periodicity (adjusted hazard ratio [AHR] = 6.2, 95% CI 2.0–19.5; p = 0.002); patients treated with AL (AHR = 6.2, 95% CI 4.6–8.5; p < 0.001), AA (AHR = 2.3, 95% CI 1.4–3.7; p = 0.001), or AM (AHR = 1.4, 95% CI 1.0–1.9; p = 0.028) compared with DP; and patients who did not clear their initial parasitaemia within 2 days (AHR = 1.8, 95% CI 1.4–2.3; p < 0.001). The analysis was limited by heterogeneity between study populations and lack of data from very low transmission settings. …”
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    The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network
  4. 703124
    “…Il n’y a pas de différence significative du nombre de formes graves de COVID 19 selon que le patient soit en phase d’initiation ou d’entretien du traitement, test de Fisher p = 0,58, OR = 1,29 [95 %CI 0,03–13,4]. Les limites de cette étude sont l’absence de groupe contrôle et de confirmation par PCR de l’ensemble des cas probables. …”
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    Pas de sur-risque de forme grave de COVID-19 chez les patients sous traitement systémique ou biologique pour du psoriasis
  5. 703125
    “…BACKGROUND: Prevention interventions for coronavirus disease (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), are currently limited to non-pharmaceutical strategies. Observational and laboratory data suggested that hydroxychloroquine (HCQ) had biologic activity against SARS-CoV-2. …”
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    LB-17. Efficacy of Hydroxychloroquine (HCQ) for Post-exposure Prophylaxis to Prevent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: A Blinded, Randomized, Controlled Trial
  6. 703126
    “…The principal findings in our study were as follows: (1) the severe acute respiratory syndrome coronavirus 2 infection rate was 13.9 per 1000 deliveries in pregnant patients (95% confidence interval, 8.3–23.2) compared with 7.3 per 1000 (95% confidence interval, 7.2–7.4) in adults aged 20 to 39 years in Washington State (rate ratio, 1.7; 95% confidence interval, 1.3–2.3); (2) the severe acute respiratory syndrome coronavirus 2 infection rate reduced to 11.3 per 1000 deliveries (95% confidence interval, 6.3–20.3) when excluding 45 cases of severe acute respiratory syndrome coronavirus disease 2 detected through asymptomatic screening (rate ratio, 1.3; 95% confidence interval, 0.96–1.9); (3) the proportion of pregnant patients in non-White racial and ethnic groups with severe acute respiratory syndrome coronavirus disease 2 infection was 2- to 4-fold higher than the race and ethnicity distribution of women in Washington State who delivered live births in 2018; and (4) the proportion of pregnant patients with severe acute respiratory syndrome coronavirus 2 infection receiving medical care in a non-English language was higher than estimates of pregnant patients receiving care with limited English proficiency in Washington State (30.4% vs 7.6%). …”
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    Higher severe acute respiratory syndrome coronavirus 2 infection rate in pregnant patients
  7. 703127
    “…INTERPRETATION: There were substantial reductions in primary care contacts for acute physical and mental conditions following the introduction of restrictions, with limited recovery by July, 2020. Further research is needed to ascertain whether these reductions reflect changes in disease frequency or missed opportunities for care. …”
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    Indirect acute effects of the COVID-19 pandemic on physical and mental health in the UK: a population-based study
  8. 703128
    “…The heterologous schedules were considered non-inferior to the approved homologous schedules if the lower limit of the one-sided 97·5% CI of the GMR of these comparisons was greater than 0·63. …”
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    Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial
  9. 703129
    “…CONCLUSION: At presentation with symptomatic COVID-19, pregnant and recently postpartum women can be stratified into high- and low-risk for progression to critical disease, even where resources are limited. This can support the nature and place of care. …”
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    An internally validated prediction model for critical COVID-19 infection and intensive care unit admission in symptomatic pregnant women
  10. 703130
    “…In the other two cohorts, the upper limit of the 95% CI exceeded the 0·25 non-inferiority margin (ChAdOx1 plus MF59C adjuvanted, trivalent influenza vaccine 10·3%, −5·44 to 26·0; BNT162b2 plus recombinant quadrivalent influenza vaccine 6·75%, −11·8 to 25·3). …”
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    Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial
  11. 703131
    “…Though East African countries share the huge burden of global under-five mortality, there is limited evidence on the incidence and predictors of under-five mortality. …”
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    Incidence and predictors of under-five mortality in East Africa using multilevel Weibull regression modeling
  12. 703132
    “…Overall, health maintenance in older patients with hemophilia appears acceptable but can certainly be improved. Limitations of our study are small sample size and that most patients have mild to moderate hemophilia. …”
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    Hemophilia in Patients 50 Years or Older: Quality of Life, Health Maintenance, Cancer Screening and COVID19
  13. 703133
    “…The current study included 124 patients (HF: 46, COPD: 53 and HF + COPD: 25) that performed advanced pulmonary function tests, echocardiography, analysis of body composition by bioimpedance and symptom-limited incremental cardiopulmonary exercise testing (CPET) on a cycle ergometer. …”
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    Responses to incremental exercise and the impact of the coexistence of HF and COPD on exercise capacity: a follow-up study
  14. 703134
    “…Compared with the AP control group, significantly fewer patients in the TOLF group reported arm/hand swelling (P=.04), heaviness (P=.03), redness (P=.03), and limited movement in shoulder (P=.02) and arm (P=.03). …”
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    A Web- and Mobile-Based Intervention for Women Treated for Breast Cancer to Manage Chronic Pain and Symptoms Related to Lymphedema: Results of a Randomized Clinical Trial
  15. 703135
    “…In the open-label cohort, 1·0 × 10(7) plaque-forming units (PFU; low dose), 1·0 × 10(8) PFU (medium dose), and 2·5 × 10(8) PFU (high dose) of COH04S1 were administered by intramuscular injection on day 0 and 28 to sentinel participants using a queue-based statistical design to limit risk. In a randomised dose expansion cohort, additional participants were randomly assigned (3:3:1), using block size of seven, to receive two placebo vaccines (placebo group), one low-dose COH04S1 and one placebo vaccine (low-dose COH04S1 plus placebo group), or two low-dose COH04S1 vaccines (low-dose COH04S1 group). …”
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    Safety and immunogenicity of a synthetic multiantigen modified vaccinia virus Ankara-based COVID-19 vaccine (COH04S1): an open-label and randomised, phase 1 trial
  16. 703136
    “…To the contrary, a conscientious practitioner may responsibly adopt a course of action different from that set forth in the standards/guidelines when, in the reasonable judgment of the practitioner, such course of action is indicated by the condition of the patient, limitations of available resources or advances in knowledge or technology subsequent to publication of the guidelines/procedure standards. …”
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    Joint EANM/SNMMI/ANZSNM practice guidelines/procedure standards on recommended use of [(18)F]FDG PET/CT imaging during immunomodulatory treatments in patients with solid tumors version 1.0
  17. 703137
    “…To the contrary, a conscientious practitioner may responsibly adopt a course of action different from that set forth in the consensus document when, in the reasonable judgement of the practitioner, such course of action is indicated by the condition of the patient, limitations of available resources, or advances in knowledge or technology subsequent to publication of the consensus document. …”
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    Evidence-based guideline of the European Association of Nuclear Medicine (EANM) on imaging infection in vascular grafts
  18. 703138
    “…AIMS/HYPOTHESIS: Time-restricted eating (TRE) is suggested to improve metabolic health by limiting food intake to a defined time window, thereby prolonging the overnight fast. …”
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    Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial
  19. 703139
    “…Les stratégies thérapeutiques, validées en COPIL, ont été adaptées afin de préserver l’usage du propofol et de limiter les entrées itératives en chambre des infirmiers diplômés d’État (mise en place de la sédation inhalée par gaz halogénés, pousse-seringue électrique de midazolam/sufentanil double concentration) et d’offrir des alternatives de choix de matériel pour les administrations actives d’anti-infectieux. …”
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    Articulation des pharmaciens (cliniciens dans les services et à la pharmacie à usage intérieur) au service du patient de réanimation en période de pandémie à SARS-CoV-2
  20. 703140
    por Appel, Katharina S, Maier, Daniel, Hopff, Sina M, Mitrov, Lazar, Stecher, Melanie, Scherer, Margarete, Geisler, Ramsia, Hagen, Marina, Haas, Kirsten, Reese, Jens-Peter, Jiru-Hillmann, Steffi, Miljukov, Olga, Jakob, Carolin E M, Nunes de Miranda, Susana M, Meybohm, Patrick, Hanß, Sabine, Erber, Johanna, Winter, Christof, Tebbe, Johannes J, Stellbrink, Christoph, Khodamoradi, Yascha, Schmidt, Julia, Hanses, Frank, Scheer, Christian, Blaschke, Sabine, Göpel, Siri, Kluge, Stefan, Witzke, Oliver, Römmele, Christoph, Krawczyk, Marcin, Teufel, Andreas, Schmid, Jonas, Pape, Daniel, Schütte, Christian, Tausche, Kristin, Milovanovic, Milena, Krug, Natalie, Tepasse, Phil-Robin, Verket, Marlo, Hamprecht, Axel, Tasci, Selcuk, Hower, Martin, Jensen, Björn-Erik O, Sprinzl, Martin F, Zimmermann, Tim, Vehreschild, Jörg J
    Publicado 2022
    “…Any interpretations regarding the omicron stratum are limited due to the sample size. DISCLOSURES: Daniel Pape, Dr., Advanz Pharma Germany: Support for attending meetings and/or travel for ECCMID 2021 Martin Hower, n/a, MSD: Advisor/Consultant|Trogarzo: Advisor/Consultant|ViiV Healthcare: Advisor/Consultant Björn-Erik O. …”
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    1886. External Validation of the 4C Mortality Score and the qSOFA for Different Variants of Concerns of SARS-CoV-2 Using Data of the NAPKON Cross-Sectoral Cohort Platform (SUEP)
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