“…An ELISA plate IC(50) inhibition assay and surface plasma resonance (SPR) binding assay of structurally well-defined HS oligosaccharides showed that 6-O-sulfation (6-O-S) and 6-O-phosphorylation (6-O-P) of HS tetrasaccharides significantly enhanced EGFR cognate growth factor binding. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso

“…In the presence of Cu(ii) and Zn(ii) the frequency shifts of PO(2)(−), C–O–C and C–O–P vibrations indicate metal binding to nucleic acids, carbohydrates and polysaccharides. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: The ratio of partial pressure of arterial oxygen (PaO(2)) to fraction of inspired oxygen (FiO(2)) increased from T(0 )to T(OLP )(120 ± 59 versus 146 ± 64 mmHg, P < 0.005), as did dynamic respiratory compliance (23 ± 5 versus 27 ± 6 ml/cmH(2)O, P < 0.005). At constant PEEP (14 ± 3 cmH(2)O) and tidal volumes, peak inspiratory pressure decreased (32 ± 3 versus 29 ± 3 cmH(2)O, P < 0.005), although partial pressure of arterial carbon dioxide (PaCO(2)) was unchanged (58 ± 22 versus 53 ± 18 mmHg). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The SHAM group's pre to post-training maximal inspiratory pressure (MIP) change was not significant (-43.5 ± 17.8 vs. -45.1 ± 19.5 cm H(2)O, P = 0.39), while the IMST group's MIP increased (-44.4 ± 18.4 vs. -54.1 ± 17.8 cm H(2)O, P < 0.0001). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the 45 upregulated genes for the P8-O/P8-N group, enriched genes were mainly related to cytoskeleton formation, whereas the 62 upregulated genes for P13-O/P13-N participated in various pathological processes. …”
Enlace del recurso
Enlace del recurso

“…Comparison of ventilation characteristics found statistically significant differences in median (pre v post): PIP (26 ± 6 v 21 ± 6 cmH2O,p < .001), Delta P (24 ± 6 v 19 ± 6 cmH2O, p < .001), Vt (588 ± 139 v 562 ± 121 ml, p < 0.001; 9.3 ± 2.2 v 9.0 ± 1.9 ml/kg predicted body weight, p < .001), FiO2 (0.57 ± 0.17 v 0.52 ± 0.18, p < .001). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We observed significant differences in VT (7.3 versus 5.4 mlKg(−1), P = 0.002) and Pplat values (30 versus 35 cmH2O, P = 0.001) between the Pplat-group and SI-group respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There was a decrease in HR (12.2 ± 9.5 beats/min; p = 0.04), CVP (4.6 ± 2.3 mmHg; p = 0.022), PCWP (5.8 ± 2.3 mmHg; p = 0.029), and PIP (10.1 ± 3.9 cmH(2)O; p < 0.001) and a mean increase in P/F ratio (70.4 ± 49.4; p < 0.001) and UO (95.3 ± 105.3 ml/h; p < 0.001). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mean PTS was significantly higher in the OSD group (11.6º ± 2.9º) compared to the control group (9.3º ± 2.7º, p<0.0001). In the OSD group, 46% of knees had a PTS ≥12º and in the control group, 19% knees had a PTS >12º (p<0.001). …”
Enlace del recurso
Enlace del recurso

“…Changes from baseline in MEP at week 8 on reldesemtiv 150 and 450 mg were significantly greater than those on placebo (LS mean differences, 11.7 [p = 0.038] and 13.2 cm H(2)O [p = 0.03], respectively). For 6MWD and MEP, significant changes from placebo were seen in the highest reldesemtiv peak plasma concentration quartile (C(max) > 3.29 μg/mL; LS mean differences, 43.3 m [p = 0.010] and 28.8 cm H(2)O [p = 0.0002], respectively). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…After the LRM, patients with high recruitability (R/I ratio ≥ 0.62) presented an improvement in the P(a)O(2)/F(i)O(2) ratio, due to significant increase in respiratory system compliance (33 [27–42] vs. 42 [35–60] mL/cmH(2)O; p < 0.001). In low recruitability patients (R/I < 0.62), the increase in P(a)O(2)/F(i)O(2) ratio was associated with a significant decrease in pulse pressure as a surrogate of cardiac output (70 [55–85] vs. 50 [51–67] mmHg; p = 0.01) but not with a significant change in respiratory system compliance (33 [24–47] vs. 35 [25–47] mL/cmH(2)O; p = 0.74). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Five minutes of ECC reduced DP from baseline 14.2 ± 1.3 to 12.3 ± 1.3 cmH(2)O (P < 0.001), explained by an improved lung compliance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Four hours after PEEP titration, median PEEP increased from 12 to 20 cm H(2)O (p < 0.0001) with a corresponding decrease in median DP from 15 to 13 cm H(2)O (p = 0.002). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In Trendelenburg position with capnoperitoneum, Open-Lung-PEEP was 18 (18–20) cmH (2) O (p < 0.0001 vs supine position) with 1.8 (0.5–3.9)% of overdistension and 0 (0–1.2)% of collapse and Best-Compromise-PEEP was 18 (16–20) cmH(2)O (p < 0.0001 vs supine position) with 1.5 (0.7–3.0)% of overdistension and 0.2 (0–2.7)% of collapse. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We make use of our findings to explain the low energy behavior of the S-factors related to some notorious capture reactions: 7Be(p, gamma)8B, 14N(p,gamma)15O, 16O}(p,gamma)17F, 20Ne(p, gamma)21Na and 22Mg(p, gamma)23Al.…”
Enlace del recurso
Enlace del recurso

“…Here we present the modelling of the kinetics of the hydroxide-promoted hydrolysis of phosphoric diesters. (2) Method: the theoretical–computational procedure involves a hybrid quantum/classical approach based on the perturbed matrix method (PMM) in conjunction with molecular mechanics. (3) Results: the presented study reproduces the experimental data both in the rate constants and in the mechanistic aspects (C–O bond vs. O–P bond reactivity). The study suggests that the basic hydrolysis of phosphodiesters occurs through a concerted [Formula: see text] mechanism, with no formation of penta-coordinated species as reaction intermediates. (4) Conclusions: the presented approach, despite the approximations, is potentially applicable to a large number of bimolecular transformations in solution and therefore leads the way to a fast and general method to predict the rate constants and reactivities/selectivities in complex environments.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this manuscript, we describe a novel and practical phosphorylating reaction under transition metal-free reaction conditions that can selectively convert carboxylic acids into the P–C–O–P motif-containing compounds through bisphosphorylation, and the benzyl phosphorus compounds through deoxyphosphorylation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The obtained hybrids have complex 3D structures and form organic–inorganic networks containing Zr-O-Zr, Zr-O-P and Zr-O-B bridges. Such organic–inorganic networks are also expected to form supramolecular structures and to have many potential applications in different fields of great interest such as catalysis, medicine, agriculture, energy storage, fuel cells, sensors, electrochemical devices and supramolecular chemistry.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A new compound, dipotassium holmium(III) phosphate(V) tungstate(VI), K(2)Ho(PO(4))(WO(4)), has been obtained during investigation of the K(2)O–P(2)O(5)–WO(3)–HoF(3) phase system using the flux technique. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso