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  1. 181
    “…The molecular induction of TRAIL-mediated apoptosis using agonistic small molecule, ONC201 in vitro cell-based proliferation assay and in vivo novel orthotopic xenograft animal models of DSRCT, was able to inhibit cell proliferation that was associated with caspase activation, and tumor growth, indicating that a cell-based delivery of an apoptosis-inducing factor could be relevant therapeutic agent to control DSRCT.…”
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    Efficacy of ONC201 in Desmoplastic Small Round Cell Tumor()
  2. 182
    “…Oritavancin, a lipoglycopeptide antibiotic was FDA-approved in 2014 as a single dose regimen for treatment of ABSSSI and may be useful for the treatment of osteomyelitis where once-weekly therapy presents logistical advantages over vancomycin. …”
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    1420. Successful Treatment of Acute Osteomyelitis with Once-Weekly Oritavancin
  3. 183
    “…An open-label prospective study to compare once-weekly thyroxine (OWT) with standard daily thyroxine (SDT) was undertaken. …”
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    Efficacy and Safety of Once-Weekly Thyroxine for Thyroxine-Resistant Hypothyroidism
  4. 184
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    Once Burnt, Twice Burnt: The Vulnerability of Insensate Flap Reconstructions
  5. 185
    por Eichengreen, Barry
    Publicado 2020
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    Coronavirus Pandemic: Europe Is Once Again Forged in a Crisis
  6. 186
    “…ONC201 was originally discovered as TNF-Related Apoptosis Inducing Ligand (TRAIL)-inducing compound TIC10. …”
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    ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
  7. 187
    por Burns, Jane C.
    Publicado 2020
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    Revisiting Once Again Steroids for the Treatment of Acute Kawasaki Disease
  8. 188
    “…Basal insulin Fc (BIF, LY3209590) is an insulin Fc-fusion protein in clinical testing as a once weekly treatment for type 1 and type 2 diabetes mellitus (T1DM, T2DM). …”
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    Preclinical Characterization of Once Weekly Basal Insulin Fc (BIF)
  9. 189
    “…A primary goal of our work is to determine if DIPG are uniquely sensitive to ONC201 and if so, whether ONC201 itself can be used as a tool to illuminate novel vulnerabilities in DIPG. …”
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    HGG-44. REVEALING VULNERABILITIES IN DIPG THROUGH ONC201
  10. 190
    por Kim, Taehyung, Mok, Jiwon, Lee, Euichul
    Publicado 2021
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    Detecting Facial Region and Landmarks at Once via Deep Network †
  11. 191
    por Yoo, Jin-Hong
    Publicado 2022
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    Once Bitten, Twice Shy: Our Attitude Towards Monkeypox
  12. 192
    por Lieberman, J.
    Publicado 2022
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    A Once Malignant Malady: the Story of Schizophrenia and the Path to Prevention
  13. 193
    por Plotnitsky, Arkady
    Publicado 2022
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    “Yet Once More”: The Double-Slit Experiment and Quantum Discontinuity
  14. 194
    “…AIMS: This study aims to evaluate the effectiveness and tolerability of once-weekly glucagon-like peptide receptor agonists (OW GLP-1RAs) and to assess the clinical benefits of switching from one GLP-1RA to another (switchers) in a routine clinical setting. …”
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    Effectiveness and Tolerability of Once-Weekly GLP-1 Receptor Agonists in Clinical Practice: A Focus on Switching Between Once-Weekly Molecules in Type 2 Diabetes
  15. 195
    “…EXTEND is an observational study assessing the effectiveness of DA administered once biweekly (Q2W) or monthly (QM) in a general CKD-NoD population. …”
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    An observational cohort study of extended dosing (once every 2 weeks or once monthly) regimens with darbepoetin alfa in patients with chronic kidney disease not on dialysis: the EXTEND study
  16. 196
    “…MATERIALS AND METHODS: Obese adults without diabetes (N = 50; aged 18‐70 years; body mass index, 30‐45 kg/m(2)) were initially randomized to double‐blind oral dapagliflozin 10 mg once daily plus subcutaneous long‐acting exenatide 2 mg once weekly or to placebo. …”
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    Dapagliflozin once daily plus exenatide once weekly in obese adults without diabetes: Sustained reductions in body weight, glycaemia and blood pressure over 1 year
  17. 197
    “…The BEmONC implementation strength index can be potentially used to monitor the implementation of BEmONC interventions. …”
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    The effect of implementation strength of basic emergency obstetric and newborn care (BEmONC) on facility deliveries and the met need for BEmONC at the primary health care level in Ethiopia
  18. 198
    “…We compared the efficacy and safety of once‐weekly alendronate oral jelly with once‐weekly alendronate tablet formulations in the context of primary osteoporosis. …”
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    Treatment with once‐weekly alendronate oral jelly compared with once‐weekly alendronate oral tablet for Japanese patients with primary osteoporosis: An open‐label, prospective, observational study
  19. 199
    “…METHODS: Adults (age ≥18 years) with type 2 diabetes, HbA(1c) 53–91 mmol/mol (7.0–10.5%), on a stable daily dose of metformin (≥1500 mg or maximum tolerated dose) and with an eGFR ≥60 ml min(−1) [1.73 m](−2) were randomised 1:1 to semaglutide 1.0 mg once weekly and canagliflozin placebo once daily, or canagliflozin 300 mg once daily and semaglutide placebo once weekly. …”
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    Effects of once-weekly semaglutide vs once-daily canagliflozin on body composition in type 2 diabetes: a substudy of the SUSTAIN 8 randomised controlled clinical trial
  20. 200
    “…[Image: see text] Insulin icodec (icodec) is a once-weekly basal insulin in development. This post hoc analysis used data from the NCT03951805 trial to investigate CGM-derived time in, above, below range (TIR, TAR, TBR) and glycemic variability measured as coefficient of variation (CV%). …”
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    Abstract 3: CGM-derived parameters for once-weekly insulin icodec versus once-daily insulin glargine U100 in insulin-Naïve patients with T2D
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