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  1. 401
    por Bomblies, Kirsten
    Publicado 2020
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    When everything changes at once: finding a new normal after genome duplication
  2. 402
    “…Given literature supporting efficacy of once-daily dosing (ODD) of 5 mg/kg for chorioamnionitis, University of Chicago Medicine made the change from three times daily dosing (TIDD) to ODD. …”
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    1314. Neonatal Serum Gentamicin Concentrations following Maternal Once-daily Gentamicin Dosing
  3. 403
    “…Concurrent chemoradiotherapy consisted of 60 Gy in 30 fractions with once-daily, orally administered S-1 exclusively within three to six hours prior to each irradiation. …”
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    Early glottic cancer treatment with concurrent chemoradiotherapy with once-daily orally administered S-1
  4. 404
    “…ONC212 is a fluorinated imipridone with preclinical efficacy against pancreatic and other malignancies. …”
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    ONC212 is a Novel Mitocan Acting Synergistically with Glycolysis Inhibition in Pancreatic Cancer
  5. 405
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    #JACCCardioOnc: Evolution of a Dedicated Social Media Strategy for JACC: CardioOncology
  6. 406
    “…METHODS: The safety, efficacy, maximum-tolerated dose (MTD) and recommended phase 2 dose (RP2D) of selinexor (80 or 100 mg) + carfilzomib (56 or 70 mg/m(2)) + dexamethasone (40 mg) (XKd) once weekly (QW) was evaluated in patients with relapsed refractory MM (RRMM) not refractory to carfilzomib. …”
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    Once weekly selinexor, carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients
  7. 407
    “…IGF-1 levels following treatment with long-acting growth hormones such as lonapegsomatropin (lonapegsomatropin-tcgd, TransCon hGH), a once-weekly somatropin prodrug, exhibit a characteristic profile over the dosing interval. …”
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    Average IGF-1 Prediction for Once-Weekly Lonapegsomatropin in Children With Growth Hormone Deficiency
  8. 408
    “…ONC201 demonstrated promising activity in patients with advanced endometrial cancer in a Phase I clinical trial. …”
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    Antitumorigenic effect of combination treatment with ONC201 and TRAIL in endometrial cancer in vitro and in vivo
  9. 409
    “…To analyze the molecular regulation mechanism of continuous flowering, comparative transcriptome data of once- and continuous-flowering roses in our previous study were used to conduct weighted gene co-expression network analysis (WGCNA) to obtain the candidate genes related to flowering transitions. …”
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    Differentially Expressed Genes Related to Flowering Transition between Once- and Continuous-Flowering Roses
  10. 410
    “…CONCLUSIONS: This study extends the knowledge of the somapacitan dose–IGF-I response and provides information on clinical dosing of once-weekly somapacitan in patients with AGHD.…”
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    Dose–exposure–IGF-I response of once-weekly somapacitan in adults with GH deficiency
  11. 411
    “…Trazodone is approved for the treatment of major depressive disorders, marketed as immediate release (IR), prolonged release, and once a day (OAD) formulation. The different formulations allow different administration schedules and may be useful to facilitate patients’ compliance to the antidepressant treatment. …”
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    Estimation of brain receptor occupancy for trazodone immediate release and once a day formulations
  12. 412
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    Water Desalination Using the Once-through Multi-Stage Flash Concept: Design and Modeling
  13. 413
    “…Aceclofenac controlled-release (CR) is a once-a-day tablet with 200 mg of aceclofenac, and is bioequivalent to conventional aceclofenac. …”
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    Safety and effectiveness of 4-week therapy with aceclofenac controlled release once a day
  14. 414
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    Enhanced You Only Look Once X for surface defect detection of strip steel
  15. 415
    “…AIMS/HYPOTHESIS: This study compared the frequency of hypoglycaemia, time to hypoglycaemia and recovery from hypoglycaemia after double or triple doses of once-weekly insulin icodec vs once-daily insulin glargine U100. …”
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    Hypoglycaemia frequency and physiological response after double or triple doses of once-weekly insulin icodec vs once-daily insulin glargine U100 in type 2 diabetes: a randomised crossover trial
  16. 416
    “…Somatrogon, a long-acting rhGH, requires less frequent, once-weekly, dosing. We describe physicians’ preference for, experiences, and satisfaction with once-weekly somatrogon vs once-daily rhGH. …”
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    Physician experience with once-weekly somatrogon versus once-daily rhGH regimen in pediatric patients with growth hormone deficiency: a cross-sectional survey of physicians from the global phase 3 study
  17. 417
    “…BACKGROUND: QVA149 is a once-daily (o.d.) inhaled dual bronchodilator containing a fixed-dose combination of the long-acting β(2)-agonist indacaterol and the long-acting muscarinic antagonist glycopyrronium for the treatment of COPD. …”
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    Efficacy and safety of once-daily QVA149 compared with the free combination of once-daily tiotropium plus twice-daily formoterol in patients with moderate-to-severe COPD (QUANTIFY): a randomised, non-inferiority study
  18. 418
    “…MATERIALS AND METHODS: In this single‐centre, double‐blind trial, we randomized 50 obese adults without diabetes (aged 18–70 years; body mass index 30–45 kg/m(2)) to oral dapagliflozin 10 mg once daily plus subcutaneous long‐acting exenatide 2 mg once weekly or placebo. …”
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    Dapagliflozin once‐daily and exenatide once‐weekly dual therapy: A 24‐week randomized, placebo‐controlled, phase II study examining effects on body weight and prediabetes in obese adults without diabetes
  19. 419
    “…SBP reductions were greater among patients with SBP ≥140 vs <140 mm Hg for exenatide once weekly plus dapagliflozin and exenatide once weekly. …”
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    Effects of exenatide once weekly plus dapagliflozin, exenatide once weekly, or dapagliflozin, added to metformin monotherapy, on body weight, systolic blood pressure, and triglycerides in patients with type 2 diabetes in the DURATION‐8 study
  20. 420
    “…OBJECTIVE: Insulin icodec (icodec) is a novel once-weekly basal insulin analog. This trial investigated two approaches for switching to icodec versus once-daily insulin glargine 100 units/mL (IGlar U100) in people with type 2 diabetes receiving daily basal insulin and one or more oral glucose-lowering medications. …”
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    Switching to Once-Weekly Insulin Icodec Versus Once-Daily Insulin Glargine U100 in Type 2 Diabetes Inadequately Controlled on Daily Basal Insulin: A Phase 2 Randomized Controlled Trial
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