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441“…It has been estimated that 13% to 22% (depending on taxonomic group) of described species have only ever been observed once. Species that have only been observed at the time and place of their original description are referred to as oncers. …”
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442por Sliwa, Jennifer Kern, Bossie, Cynthia A, Fu, Dong-Jing, Turkoz, Ibrahim, Alphs, Larry“…BACKGROUND: A post hoc analysis from a multiphase trial with open-label transition and maintenance phases, a double-blind relapse prevention phase, and an optional open-label extension examined the long-term tolerability with continuous once-monthly injectable paliperidone palmitate 39, 78, 117, or 156 mg (25, 50, 75, or 100 mg equivalents [mg eq] of paliperidone) in subjects with recently diagnosed (≤5 years; n = 216) versus chronic illness (>5 years; n = 429) schizophrenia. …”
Publicado 2012
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443“…BACKGROUND: Type 2 diabetes mellitus is a progressive metabolic disease necessitating therapies with sustained efficacy and safety over time. Exenatide once weekly (ExQW), an extended-release formulation of the glucagon-like peptide-1 receptor agonist exenatide, has demonstrated improvements in glycemic and cardiometabolic measures from 30 weeks to 2 years of treatment. …”
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444
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445por Yun, Ji Young, Kim, Han-Joon, Lee, Jee-Young, Kim, Young Eun, Kim, Ji Seon, Kim, Jong-Min, Jeon, Beom S“…This study compares once-daily and twice-daily RPR in patients with Parkinson’s disease. …”
Publicado 2013
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446por Lee, Ji Hyun, Jee, Byung Chul, Suh, Chang Suk, Kim, Seok Hyun, Choi, Young Min, Kim, Jung Gu, Moon, Shin Yong“…OBJECTIVE: To assess the efficacies of once-weekly bisphosphonates on bone mineral density (BMD) gains in Korean women aged 50 years or more. …”
Publicado 2013
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447por Tanaka, Ikuko, Sato, Masayo, Sugihara, Tomoko, Faries, Douglas E., Nojiri, Shuko, Graham-Clarke, Peita, Flynn, Jennifer A., Burge, Russel T.“…Our findings suggest that real-world adherence and persistence with once-daily teriparatide in Japan are similar to that with once-daily teriparatide in other countries and with other osteoporosis medications.…”
Publicado 2013
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448por Onishi, Yukiko, Koshiyama, Hiroyuki, Imaoka, Takeshi, Haber, Harry, Scism‐Bacon, Jamie, Boardman, Marilyn K“…The aim of this study was to evaluate the safety of exenatide once weekly in Japanese patients, a subset of the initial patient population, who continued into this extension study for an additional 26 weeks of therapy on exenatide once weekly, followed by 10 weeks without exenatide once weekly. …”
Publicado 2012
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449por Thorat, Ashok, Chou, Hong-Shiue, Lee, Chen-Fang, Soong, Ruey-Shyang, Wu, Tsung-Han, Cheng, Chih-Hsien, Wu, Ting-Jung, Chan, Kun-Ming, Lee, Wei-Chen“…Prolonged-release tacrolimus is the once-daily formulation and may be more convenient for patients. …”
Publicado 2014
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450“…Neither Salofalk Granu-Stix(®), nor MMX 5-ASA, nor Pentasa(®) granules have initially been developed for once-daily (OD) dosing. A review of the achievements of 20 years of 5-ASA development has demonstrated that 5-ASA has equal efficacy compared with SASP at best, that there are no measurable differences in efficacy between various 5-ASA preparations, and that in a group of patients tolerating SASP, adverse event profiles of SASP and 5-ASA did not differ significantly, with SASP being the far cheaper substance. …”
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452por Tanaka, Sakae, Adachi, Taiji, Kuroda, Tatsuhiko, Nakamura, Toshitaka, Shiraki, Masataka, Sugimoto, Toshitsugu, Takeuchi, Yasuhiro, Saito, Mitsuru, Bilezikian, John P“…The aim of the present study was to explain changes in bone turnover markers using once-weekly teriparatide with a simulation model. …”
Publicado 2014
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453“…Loulu palms (Pritchardia spp.) once dominated many lowland ecosystems in Hawai‘i, and non-native rats (Rattus spp.), ungulates (e.g. pigs Sus scrofa, goats Capra hircus) and humans have been proposed as major causes of their decline. …”
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454por Dell’Atti, Lucio“…Group A (GA) counted 23 patients treated with IVI; Group B (GB) treated 19 patients with tadalafil 5 mg once a day, and Group C (GC) treated 17 patients with IVI and tadalafil for 3 months. …”
Publicado 2015
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455“…Since 2012, a new generation GLP-1 agent, exenatide once weekly (QW), has been available for patients with T2DM in the USA, but not as yet in the People’s Republic of China. …”
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456
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457
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458por Orechia, John, Pathak, Ameet, Shi, Yunling, Nawani, Aniket, Belozerov, Andrey, Fontes, Caitlin, Lakhiani, Camille, Jawale, Chetan, Patel, Chetansharan, Quinn, Daniel, Botvinnik, Dmitry, Mei, Eddie, Cotter, Elizabeth, Byleckie, James, Ullman-Cullere, Mollie, Chhetri, Padam, Chalasani, Poornima, Karnam, Purushotham, Beaudoin, Ronald, Sahu, Sandeep, Belozerova, Yelena, Mathew, Jomol P.“…In order to overcome these barriers, we developed an overarching enterprise informatics framework for translational research and personalized medicine called Synergistic Patient and Research Knowledge Systems (SPARKS) and a suite of tools called Oncology Data Retrieval Systems (OncDRS). OncDRS enables seamless data integration, secure and self-navigated query and extraction of clinical and genomic data from heterogeneous sources. …”
Publicado 2015
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460“…RESULTS: Although initially investigated for twice-daily dosing, early observations, including the finding that the pharmacodynamic effects of rivaroxaban last longer than the elimination half-life, suggested that once-daily dosing might be attainable and effective. …”
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