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  1. 661
    por Kugler, Anne J, Thiman, Michael L
    Publicado 2018
    “…Dulaglutide is a once-weekly glucagon-like peptide-1 receptor agonist, which has been on the market in the USA since 2014. …”
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    Efficacy and safety profile of once-weekly dulaglutide in type 2 diabetes: a report on the emerging new data
  2. 662
    “…Changes in glycaemic measures in response to treatment with once‐weekly dulaglutide were evaluated in each HOMA2‐%B tertile. …”
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    Effect of once weekly dulaglutide by baseline beta‐cell function in people with type 2 diabetes in the AWARD programme
  3. 663
    “…Accordingly, unlike the mono-ferrocenylalkyl-substituted products, the compounds containing two ferrocenylalkyl substituents in the opposite regions of the impiridone core display a much more pronounced long-term cytotoxic effect against A-2058 cell line than do the organic impiridones including ONC201 and ONC212. Furthermore, the prepared bis-metallocene derivatives also present substantial activity against COLO-205- and EBC-1 cell lines.…”
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    Ferrocene-Containing Impiridone (ONC201) Hybrids: Synthesis, DFT Modelling, In Vitro Evaluation, and Structure–Activity Relationships
  4. 664
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    HIV virologic response better with single-tablet once daily regimens compared to multiple-tablet daily regimens
  5. 665
    “…The aim of this study is to evaluate the efficacy of once-daily 5 mg tadalafil in pain control and improving quality of life in patients affected by CP/CPPS. …”
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    Once-daily 5 mg tadalafil oral treatment for patients with chronic prostatitis/chronic pelvic pain syndrome
  6. 666
    “…This experiment aimed to investigate the efficacy of twice‐daily, nonconsecutive heat acclimation (TDHA) in comparison to once‐daily heat acclimation (ODHA) and work matched once‐ or twice‐daily temperate exercise (ODTEMP, TDTEMP) for inducing heat adaptations, improved exercise tolerance, and cytokine (immune) responses. …”
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    Once‐ and twice‐daily heat acclimation confer similar heat adaptations, inflammatory responses and exercise tolerance improvements
  7. 667
    “…METHODS: We compared outcomes of patients 70 years of age or older versus younger patients within the Concurrent Once-daily Versus twice-daily RadioTherapy (CONVERT) trial. …”
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    Compliance and Outcome of Elderly Patients Treated in the Concurrent Once-Daily Versus Twice-Daily Radiotherapy (CONVERT) Trial
  8. 668
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    Multifocal pulmonary mucinous cystic neoplasm with ovarian-like stroma: Once in a blue moon-case report
  9. 669
    “…Objective: Ertugliflozin is approved in the US and European Union as a stand-alone product for adults with type 2 diabetes mellitus as once daily (QD) dosing. The approved fixed-dose combination (FDC) of ertugliflozin and immediate-release metformin is dosed twice daily (BID). …”
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    A PK/PD study comparing twice-daily to once-daily dosing regimens of ertugliflozin in healthy subjects
  10. 670
    “…OBJECTIVE: To evaluate the effect of aripiprazole once-monthly 400 mg (AOM 400; Abilify Maintena(®)) on personal and social functioning in patients with schizophrenia in both the acute treatment and maintenance therapy settings. …”
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    The effect of aripiprazole once-monthly on personal and social functioning: post hoc analyses of acute and long-term studies
  11. 671
    “…The formulations may be used to reduce the oral dose frequency from daily to once weekly in order to treat uncomplicated TB.…”
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    Spray-Dried, Nanoencapsulated, Multi-Drug Anti-Tuberculosis Therapy Aimed at Once Weekly Administration for the Duration of Treatment
  12. 672
    “…INTRODUCTION: While a 56.5-μg once-weekly regimen of teriparatide has high efficacy for osteoporosis, treatment continuation rates are low, with one of the major causes being adverse drug reactions such as nausea or vomiting. …”
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    Study of twice-weekly injections of Teriparatide by comparing efficacy with once-weekly injections in osteoporosis patients: the TWICE study
  13. 673
    “…We present the protocol for the ongoing INTREPID (INvestigation of TRelegy Effectiveness: usual PractIce Design; ClinicalTrials.gov identifier: NCT03467425) study, a randomised, open-label, 24-week effectiveness study of once-daily fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI; Trelegy) delivered by the ELLIPTA inhaler versus non-ELLIPTA multiple-inhaler triple therapy in patients with chronic obstructive pulmonary disease (COPD) in usual practice settings. …”
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    Clinical effectiveness of once-daily fluticasone furoate/umeclidinium/vilanterol in usual practice: the COPD INTREPID study design
  14. 674
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    Long‐term efficacy and safety of once‐monthly pasireotide in Cushing's disease: A Phase III extension study
  15. 675
    “…INTERVENTIONS: Patients were randomized 2:2:1 to once-weekly somapacitan, daily GH, or once-weekly placebo for 34 weeks (main period). …”
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    Once-weekly Somapacitan is Effective and Well Tolerated in Adults with GH Deficiency: A Randomized Phase 3 Trial
  16. 676
    “…OBJECTIVE: To investigate the feasibility and efficacy of the Ambu® AuraOnce™ laryngeal mask (LMA) compared with endotracheal intubation (ETI) during supratentorial tumor resection in the right lateral decubitus position. …”
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    Comparative study of the Ambu® AuraOnce™ laryngeal mask and endotracheal intubation in anesthesia airway management during neurosurgery
  17. 677
    por Guimarães, F., Winck, J.C.
    Publicado 2020
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    COVID-19: Once upon a time in Portugal: A brief atlas of ongoing pandemic Portuguese research
  18. 678
    “…Over periods of treatment up to 78 weeks, oral semaglutide 7 and 14 mg once daily reduced HbA1c and body weight across the spectrum of T2D, and improved other diabetes‐related endpoints, such as fasting plasma glucose. …”
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    Efficacy, safety and cardiovascular outcomes of once‐daily oral semaglutide in patients with type 2 diabetes: The PIONEER programme
  19. 679
    “…The aim of this article is to illustrate how regulatory guidance is implemented during the clinical development of generic immunosuppressants, using a generic, once-daily prolonged-release formulation of tacrolimus as an example.…”
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    Meeting Regulatory Requirements for Drugs with a Narrow Therapeutic Index: Bioequivalence Studies of Generic Once-Daily Tacrolimus
  20. 680
    por Patel, Dhiren
    Publicado 2020
    “…In the robust head‐to‐head trials of QW versus QW GLP‐1 RAs, semaglutide s.c. was superior to both dulaglutide and exenatide ER regarding HbA(1c) and body weight; however, QW versus once‐daily GLP‐1 RA trials had mixed results depending on the comparators. …”
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    Glycaemic and non‐glycaemic efficacy of once‐weekly GLP‐1 receptor agonists in people with type 2 diabetes
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