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581“…Development of software has been carried out for the rapid capture of curatorial data, and optical character recognition (OCR) software is being used to increase the efficiency of capturing label data and supplementary data. …”
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582“…This sensory and circuit-mediated regulation of chemoreceptor gene expression is dependent on cell-autonomous pathways acting in ADL, e.g. KIN-29, DAF-2, OCR-2 and calcium signaling, and circuit inputs from RMG mediated by NPR-1. …”
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583por Kogot-Levin, Aviram, Saada, Ann, Leibowitz, Gil, Soiferman, Devorah, Douiev, Liza, Raz, Itamar, Weksler-Zangen, Sarah“…Surprisingly, cellular ATP content, oxygen consumption rate (OCR) and the extracellular acidification rate (ECAR) were unchanged. …”
Publicado 2016
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584por Zhang, Xiaolong, Lan, Linhua, Niu, Lili, Lu, Juping, Li, Changxi, Guo, Miaomiao, Mo, Shouyong, Lu, Jing, Liu, Yongzhang, Lu, Bin“…We further found that TE-1 cells treated with CoCl(2), a hypoxia-mimicking reagent, dramatically reduced the oxygen consumption rate (OCR) and increased the extracellular acidification rate (ECAR). …”
Publicado 2017
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585por Peng, Yanyan, Shinde, Deepali N, Valencia, C Alexander, Mo, Jun-Song, Rosenfeld, Jill, Truitt Cho, Megan, Chamberlin, Adam, Li, Zhuo, Liu, Jie, Gui, Baoheng, Brockhage, Rachel, Basinger, Alice, Alvarez-Leon, Brenda, Heydemann, Peter, Magoulas, Pilar L, Lewis, Andrea M, Scaglia, Fernando, Gril, Solange, Chong, Shuk Ching, Bower, Matthew, Monaghan, Kristin G, Willaert, Rebecca, Plona, Maria-Renee, Dineen, Rich, Milan, Francisca, Hoganson, George, Powis, Zoe, Helbig, Katherine L, Keller-Ramey, Jennifer, Harris, Belinda, Anderson, Laura C, Green, Torrian, Sukoff Rizzo, Stacey J, Kaylor, Julie, Chen, Jiani, Guan, Min-Xin, Sellars, Elizabeth, Sparagana, Steven P, Gibson, James B, Reinholdt, Laura G, Tang, Sha, Huang, Taosheng“…In vitro enzymatic assays in patient fibroblast cells showed deficient ferredoxin NADP reductase activity and mitochondrial dysfunction evidenced by low oxygen consumption rates (OCRs), complex activities, ATP production and increased reactive oxygen species (ROS). …”
Publicado 2017
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586por Liu, Hao, Wang, Jikun, Wang, Dan, Kong, Minghua, Ning, Chao, Zhang, Xing, Xiao, Jinlong, Zhang, Xin, Liu, Jianfeng, Zhao, Xingbo“…Referring to mitotypes, the cybrids with prolific mitotypes presented significantly higher oxygen consumption rate (OCR) productions, mtDNA transcriptions and copy numbers than those with common mitotypes, while both mRNA and protein expressions of PPARA, TFAM, ER1, ER2, and ESRRG in prolific cybrids were significantly higher than those with common mitotypes. …”
Publicado 2020
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587por Ye, Liang, Zhang, Xinyuan, Zhou, Qin, Tan, Bin, Xu, Hao, Yi, Qin, Yan, Liang, Xie, Min, Zhang, Yin, Tian, Jie, Zhu, Jing“…We found that activation of AMPK improved mitochondrial oxidative phosphorylation (OxPhos) and the oxygen consumption rate (OCR). Additionally, our data demonstrated that activation of AMPK increased mitochondrial fusion to promote the maturation of mitochondrial structure and function. …”
Publicado 2021
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588por Kim, Bokyung, Lee, Jae-Jin, Shin, Ji Soo, Suh, Ji-Wan, Jung, Sunhee, Hwang, Geum-Sook, Lee, Hee-Yoon, Lee, Kong-Joo“…NMac1 causes significant activation of AMPK by decreasing ATP synthesis, lowers mitochondrial membrane potential (MMP, ΔΨm), and inhibits oxygen consumption rate (OCR) under glucose starvation. These effects of NMac1 are provoked by a consequence of OXPHOS complex I inhibition. …”
Publicado 2021
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589por Bao, Keting, Liu, Wenwen, Song, Zhouzhi, Feng, Jiali, Mao, Zhifan, Bao, Lingyuan, Sun, Tianyue, Hu, Zelan, Li, Jian“…Besides, JM03 improves the ability of nematode to resist oxidative stress and hypertonic stress through OSM-9, but not osm-9/capsaicin receptor related-2 (OCR-2). Then the inhibition of OSM-9 by JM03 reduces the aggregation of Q35 in C. elegans via upregulating the genes associated with proteostasis. …”
Publicado 2022
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590“…Consistently, Aβ induced the senescence-associated mitochondrial dysfunctions such as repression of ATP production, oxygen consumption rate (OCR), and mitochondrial membrane potential and enhancement of ROS production. …”
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591por Hernandez-Cravero, Bruno, Gallino, Sofia, Florman, Jeremy, Vranych, Cecilia, Diaz, Philippe, Elgoyhen, Ana Belén, Alkema, Mark J., de Mendoza, Diego“…Here we show that mutations in the ocr-2 and osm-9 genes, coding for transient receptors potential V (TRPV) ion channels, dramatically reduce the effect of 2-AG in cholesterol mobilization. …”
Publicado 2022
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592por Zhu, Jiebo, Lee, Min Joung, An, Jong Hun, Oh, Eungseok, Chung, Woosuk, Heo, Jun Young“…This increase was accompanied by a concurrent decrease in oxygen consumption rate (OCR) and mitochondrial membrane potential (MMP), in association with the up-regulation of the UPRmt. …”
Publicado 2023
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593por Liang, Beibei, Jiang, Yuan, Song, Shaohua, Jing, Wei, Yang, Hao, Zhao, Li, Chen, Ya, Tang, Qiqi, Li, Xuhui, Zhang, Lisha, Bao, Haili, Huang, Gang, Zhao, Jian“…In this study, we report that the haploinsufficient tumour suppressor ASPP2, can inhibit HCC growth and stemness characteristics by regulating the Warburg effect through the WNT/β‐catenin pathway. we performed glucose uptake, lactate production, pyruvate production, ECAR and OCR assays to verify ASPP2 can inhibit glycolysis in HCC cells. …”
Publicado 2023
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594por Lizneva, Daria, Gumerova, Anisa, Ievleva, Kseniia, Barak, Orly, Korkmaz, Funda, Roig, Judit Gimenez, Frolinger, Tal, Pevnev, Georgii, Sultana, Farhath, Kramskiy, Natan, Wizman, Soleil, Orloff, Michelle, Pallapati, Anusha Rani, Rojekar, Satish, Ryu, Vitaly, Moldavski, Ofer, Yuen, Tony, Zaidi, Mone“…To study whether, in addition to reducing adipocyte differentiation, LHCGR agonism also enhanced thermogenesis, 3T3-L1 adipocytes were pretreated with ORG43553 for 1 hour before measuring oxygen consumption rate (OCR) on a Seahorse Xf96 Analyzer. ORG43553 increased OCR at baseline and upon oligomycin exposure, indicating mitochondria proton leak (thermogenesis). …”
Publicado 2023
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595por Rostom, Hussam, Meng, Xin, Humphrey, Robert, Fry, Alexandria, Elajnaf, Taha, Hannan, Fadil“…Akt regulates oxidative phosphorylation, which we assessed by measuring oxygen consumption rate (OCR) and ATP synthesis. HMECs treated with 10nM T3 for ≤8hrs showed a 2-fold increase in OCR (p<0.05, n=4) without any change in cellular ATP. …”
Publicado 2023
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596por Hasheminasab, Seyed Sajjad, Conejeros, Iván, D. Velásquez, Zahady, Borggrefe, Tilman, Gärtner, Ulrich, Kamena, Faustin, Taubert, Anja, Hermosilla, Carlos“…Extracellular acidification rates (ECAR) and oxygen consumption rates (OCR) were not increased in C. parvum-exposed cells, according to measurements of PMN energetic state. …”
Publicado 2022
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597por Dong, Yuanlin, Vipin, Vidyadharan Alukkal, Blesson, Chellakkan Selvanesan, Yallampalli, Chandrasekhar“…In this study we demonstrated that: (1) Increasing doses of glucose and ADM inhibit human adipocyte mRNA expressions of mitochondrial DNA (mtDNA)-encoded subunits of electron transport chain (ETC), including nicotinamide adenine dinucleotide dehydrogenase (ND) 1 and 2, cytochrome (CYT) b, as well as ATPase 6; (2) ADM significantly increases human adipocyte mitochondrial reactive oxygen species (ROS) generation and this increase is reversed by ADM antagonist, ADM22–52, but does not significantly affect adipocyte mitochondrial contents; (3) Adipocyte basal and maximal oxygen consumption rate (OCR) are dose-dependently suppressed by ADM, and results in impaired mitochondrial respiratory capacity. …”
Publicado 2023
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598por Giovarelli, Matteo, Serati, Anais, Zecchini, Silvia, Guelfi, Fabiola, Clementi, Emilio, Mandò, Chiara“…CONCLUSIONS: By this protocol, Oxygen Consumption Rate (OCR) measurements of fresh and cryopreserved placental specimens are comparable whereas snap frozen procedure impairs mitochondrial activity. …”
Publicado 2023
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599por Mukherjee, Sandip, Chakraborty, Molee, Haubner, Jake, Ernst, Glen, DePasquale, Michael, Carpenter, Danielle, Barrow, James C., Chakraborty, Anutosh“…Furthermore, LI-2242 enhances the mitochondrial oxygen consumption rate (OCR) and insulin signaling in adipocytes and hepatocytes in vitro. …”
Publicado 2023
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600por Nashimoto, Yuji, Shishido, Shotaro, Onuma, Kunishige, Ino, Kosuke, Inoue, Masahiro, Shiku, Hitoshi“…Scanning electrochemical microscopy measurements enabled the analysis of the oxygen consumption rate (OCR) for individual organoids as small as 100 µm in diameter and could detect the heterogeneity amongst studied subpopulations, which was not observed in conventional colorectal cancer cell lines. …”
Publicado 2023
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