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641por Chen, Kuan-Chou, Chen, Chang-Rong, Chen, Chang-Yu, Tzou, Kai-Yi, Peng, Chiung-Chi, Peng, Robert Y.“…Bic elicited mitochondrial swelling and reduced the mitochondrial potential, resulting in severe suppression of the oxygen consumption rate (OCR), maximum respiration and ATP production. The hypoxia-inducible factor (HIF)-1α transcriptional activity and messenger RNA were significantly upregulated in dose-dependent manners. …”
Publicado 2020
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642“…Importantly, the combined siRNA approach against Fis1 and Drp1 prevented HG-induced changes in the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR). …”
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643“…In addition, measurements of the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) indicated that PURα promoted the metabolism of ESCC cells. …”
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644Publicado 2021“…Methods and procedures: To reach this objective we: (1) preprocess the ECG records, which includes skew correction, background grid removal and linear filtering; (2) segment ECG signals using Connected Components Analysis (CCA); (3) implement Optical Character Recognition (OCR) for removal of overlapping ECG lead characters and for interfacing of patients’ demographic information with their research records or their electronic medical record (EMR). …”
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645“…Here, we show that after exposure to FB1 and AFB1, mitochondrial respiration significantly decreased by measuring the oxygen consumption rate (OCR), mitochondrial membrane potential (MMP) and reactive oxygen species (ROS). …”
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646“…Then, the endpoint of the gauge pointer is found to calculate the corresponding angles to the gauge’s center. Using OCR (optical character recognition), the corresponding dial values can be extracted to match with their scale marks. …”
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647“…Therefore, to disambiguate these features, we propose to implement a Ternion stream deep convolutional neural network (TSDCNN) over non-overlapping cameras and combine all key vehicle features such as shape, license plate number, and optical character recognition (OCR). Then jointly investigate the strategic analysis of visual vehicle information to find and identify vehicles in multiple non-overlapping views of algorithms. …”
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648por Li, Jin-Feng, Hu, Wen-Yu, Chang, Hai-Xia, Bao, Jin-Hao, Kong, Xiang-Xi, Ma, Hui, Li, Yun-Feng“…Behavioral tests were applied to evaluate the depression model; immunofluorescence and immunohistochemistry staining were used to explore morphological changes in astrocytes; astrocyte-specific RNA sequencing (RNA-Seq) analysis was performed to capture transcriptome wide alterations; and ATP and oxygen consumption rate (OCR) levels of primary astrocytes were measured, followed by YL-0919 incubation to appraise the alteration of energy metabolism and mitochondrial oxidative phosphorylation (OXPHOS). …”
Publicado 2023
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649“…Mitochondrial functional assessments specifically can detect dysfunction through oxygen consumption rate (OCR), spare respiratory capacity, and maximal respiration measurements, which, when coupled with disease activity scores could show potential as markers of disease activity. …”
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650por Akagi, Satoshi, Nakamura, Kazufumi, Kondo, Megumi, Hirohata, Satoshi, Udono, Heiichiro, Nishida, Mikako, Saito, Yukihiro, Yoshida, Masashi, Miyoshi, Toru, Ito, Hiroshi“…Methods: We investigated the enzymes involved in glycolysis and mitochondrial respiration, and studied the two major energy-yielding pathways (glycolysis and mitochondrial respiration) by measuring extracellular acidification rate (ECAR) and cellular oxygen consumption rate (OCR) using the Seahorse extracellular flux technology. …”
Publicado 2023
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651por Ramesh, SaiShyam, Cihalova, Daniela, Rajendran, Esther, Van Dooren, Giel G., Maier, Alexander G.“…This approach measures the O(2) consumption rate (OCR) of permeabilized P. falciparum parasites using a Seahorse XFe96 flux analyzer and can be used to screen compound libraries for the identification of ETC inhibitors and, in part, to determine the targets of those inhibitors. …”
Publicado 2023
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652“…RESULTS: The sample included abstracts on 326 controlled clinical trials (CCT), 336 other clinical research reports (OCR), and 174 basic science studies (BSS). 392 abstracts (47%) were published as full papers. …”
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653por Estrada, J C, Torres, Y, Benguría, A, Dopazo, A, Roche, E, Carrera-Quintanar, L, Pérez, R A, Enríquez, J A, Torres, R, Ramírez, J C, Samper, E, Bernad, A“…Overexpression of the telomerase catalytic subunit (human telomerase reverse transcriptase, hTERT) inhibited senescence, markedly reducing the levels of aneuploidy and preventing the dysregulation of ploidy-controlling genes. hMSC-replicative senescence was accompanied by an increase in oxygen consumption rate (OCR) and oxidative stress, but in long-term cultures that overexpress hTERT, these parameters were maintained at basal levels, comparable to unmodified hMSCs at initial passages. …”
Publicado 2013
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654A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migrationpor Yizhak, Keren, Le Dévédec, Sylvia E, Rogkoti, Vasiliki Maria, Baenke, Franziska, de Boer, Vincent C, Frezza, Christian, Schulze, Almut, van de Water, Bob, Ruppin, Eytan“…Furthermore, in accordance with the predictions, a significant reduction is observed in the ratio between experimentally measured ECAR and OCR levels following these perturbations. Inhibiting anti-migratory targets is a promising future avenue in treating cancer since it may decrease cytotoxic-related side effects that plague current anti-proliferative treatments. …”
Publicado 2014
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655por Braga, Tarcio Teodoro, Forni, Maria Fernanda, Correa-Costa, Matheus, Ramos, Rodrigo Nalio, Barbuto, Jose Alexandre, Branco, Paola, Castoldi, Angela, Hiyane, Meire Ioshie, Davanso, Mariana Rodrigues, Latz, Eicke, Franklin, Bernardo S., Kowaltowski, Alicia J., Camara, Niels Olsen Saraiva“…Nlrp3(−/−) macrophages presented a protected redox state, increased maximum and reserve oxygen consumption ratio (OCR) and higher VDAC protein levels when compared to WT and Myd88(−/−) cells. …”
Publicado 2017
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656por Liu, Qian, Wang, Qihan, Xu, Cheng, Shao, Wentao, Zhang, Chunlan, Liu, Hui, Jiang, Zhaoyan, Gu, Aihua“…Furthermore, MitoTracker Green fluorescence, ATP levels, mitochondrial membrane potential and OCR decreased in HepG2 cells exposed to OCPs. In conclusion, chronic exposure to OCPs at doses equivalent to internal exposures in humans impaired mitochondrial function, decreased fatty acid β-oxidation and aggravated disorders of fatty acid metabolism.…”
Publicado 2017
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657“…In cybrids there were generally higher rates of oxygen consumption (OCR) and extracellular acidification (ECAR), and lower mRNA expression levels of nuclear-encoded mitochondrial genes, potentially reflecting active energy metabolism and cellular stress resistance. …”
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658por Merzougui, Latifa, Marwen, Nedia, Barhoumi, Tarek, Ltaeifa, Afef Ben, Hannachi, Hajer, Jaballah, Roukaya, Fatnassi, Ridha“…The overall compliance rate (OCR) of partograph use in our audit was 55.9%. With regard to the first area, such as « La tenue du partogramme » (partograph use, PARTOten) the overall compliance rate was 88, 9%. …”
Publicado 2017
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659por Martorana, Francesca, Gaglio, Daniela, Bianco, Maria Rosaria, Aprea, Federica, Virtuoso, Assunta, Bonanomi, Marcella, Alberghina, Lilia, Papa, Michele, Colangelo, Anna Maria“…These molecular events correlate with modifications of energy and redox homeostasis, as determined by ATP and NADPH changes, higher oxygen consumption (OCR) and ROS production. Our data indicate that autophagy aims to clear out exhausted mitochondria, as determined by enhanced localization of p62 and Lysotracker-red to mitochondria. …”
Publicado 2018
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660por Khiatah, Bashar, Tucker, Amber, Chen, Kuan-Tsen, Perez, Rachel, Bilbao, Shiela, Valiente, Luis, Medrano, Leonard, Rawson, Jeffrey, Forouhar, Elena, Omori, Keiko, Kandeel, Fouad, Qi, Meirigeng, Al-Abdullah, Ismail H.“…The isolation outcomes were assessed by islet counting, viability, glucose-stimulated oxygen consumption rate (OCR), and successful graft-rate following transplantation in diabetic NOD scid mice. …”
Publicado 2018
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