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  1. 261
    “…The liver, spleen, kidneys, and red marrow dose per administered activity (AD/A admin) values were calculated with the Medical Internal Radiation Dose (MIRD) formalism and the residence times (Dosimetry toolkit® application) using standard and CT imaging-based organ masses (OLINDA/EXM® V1.0 software). RESULTS: Sensitivity factors of 6.11 ± 0.01 and 5.67 ± 0.08 counts/s/MBq were obtained with planar and SPECT/CT acquisitions, respectively. …”
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    Implementation of patient dosimetry in the clinical practice after targeted radiotherapy using [(177)Lu-[DOTA0, Tyr3]-octreotate
  2. 262
    “…Time-activity curves of different source organs were obtained from the image sequence to adjust the biokinetic models. The OLINDA/EXM code was employed to calculate the equivalent and effective radiation doses. …”
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    (99m)Tc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans
  3. 263
    “…Full body distribution of [(18)F]FNDP was studied in CD-1 mice, and the human effective dose was estimated using OLINDA/EXM software. RESULTS: [(18)F]FNDP exhibited high and rapid brain uptake in baboons. …”
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    PET imaging of soluble epoxide hydrolase in non-human primate brain with [(18)F]FNDP
  4. 264
    “…Human dosimetry was estimated using OLINDA software. RESULTS: The mean decay-corrected yields of [(18)F]MC225 at end of synthesis were 13%, with > 99% radiochemical purity, > 1000 GBq/μmol molar activity, and ≤ 1.5 μg/185 MBq of total chemical contents. …”
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    Automated synthesis, preclinical toxicity, and radiation dosimetry of [(18)F]MC225 for clinical use: a tracer for measuring P-glycoprotein function at the blood-brain barrier
  5. 265
    “…Sequential whole-body planar images were acquired 0.5–1, 16–24, 36–48, and 120 h post-injection. (177)Lu time-activity curves were corrected for (225)Ac physical decay and assumed in equilibrium for all daughters. The OLINDA/EXM spherical model was used for dose estimation of the parotid and submandibular glands. …”
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    Targeted Alpha Therapy in mCRPC (Metastatic Castration-Resistant Prostate Cancer) Patients: Predictive Dosimetry and Toxicity Modeling of (225)Ac-PSMA (Prostate-Specific Membrane Antigen)
  6. 266
    “…Dosimetry estimates for risk organs were determined using a combined linear-monoexponential model, and by applying (18)F S-values and reference target masses for the ICRP89 adult male or female (OLINDA 2.0). Tumour-to-background ratios were compared quantitatively and visually between different scan times. …”
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    Dosimetry and optimal scan time of [(18)F]SiTATE-PET/CT in patients with neuroendocrine tumours
  7. 267
    “…Estimates of the absorbed radiation dose in humans were calculated with OLINDA/EXM 1.1 using the adult male reference model. …”
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    Target occupancy study and whole-body dosimetry with a MAGL PET ligand [(11)C]PF-06809247 in non-human primates
  8. 268
    “…Mean organ-absorbed doses and effective doses were calculated using the OLINDA software. Tracer bioactivity was evaluated via cell-binding assays, and metabolites from human blood samples were analyzed with analytic radio–high-performance liquid chromatography. …”
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    First-in-Humans Evaluation of Safety and Dosimetry of (64)Cu-LLP2A for PET Imaging
  9. 269
    “…Such data were processed to calculate the parameters Δp(in)(NOR) = (DR(in)(max)- DR(in)(mean))/DR(in)(max) and ΔR(t) = (DR(in)(t) − DR(con)(t)), where DR(in)(max) is the maximum DR value, DR(in)(mean) is the average DR value in the injected arm. OLINDA software allowed dosimetric estimation of the dose in the extravasation region. …”
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    Safety injections of nuclear medicine radiotracers: towards a new modality for a real-time detection of extravasation events and (18)F-FDG SUV data correction
  10. 270
    “…Finally, combined with the OLINDA/EXM software, effective doses of the different tracers and individual organ doses were calculated. …”
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    Biodistribution and radiation dosimetry of multiple tracers on total-body positron emission tomography/computed tomography
  11. 271
    “…Volumes of interest were defined for tumor lesions and normal organs at each time point followed by dose calculations using the OLINDA/EXM software. Twenty-eight men with mCRPC were treated with a single cycle of (131)I-MIP-1095 (mean activity: 4.8 GBq, range 2 to 7.2 GBq) and followed for safety and efficacy. …”
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    Radiation dosimetry and first therapy results with a (124)I/(131)I-labeled small molecule (MIP-1095) targeting PSMA for prostate cancer therapy
  12. 272
    “…The time–activity curves of source organs were extrapolated from (203)Pb to (212)Pb and the calculated residence times of (212)Pb were forwarded to its unstable daughter nuclides. QDOSE and OLINDA were used for dosimetry calculations. RESULTS: In vitro, all ligands showed low nanomolar binding affinities for PSMA. …”
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    Development and dosimetry of (203)Pb/(212)Pb-labelled PSMA ligands: bringing “the lead” into PSMA-targeted alpha therapy?
  13. 273
    “…The whole-body mean effective dose of [(18)F]DiFA estimated by using the medical internal radiation dose (MIRD) schema with organ level internal dose assessment/exponential modeling (OLINDA/EXM) computer software 1.1 was 14.4 ± 0.7 μSv/MBq. …”
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    Biodistribution and radiation dosimetry of the novel hypoxia PET probe [(18)F]DiFA and comparison with [(18)F]FMISO
  14. 274
    “…The absorbed dose of the salivary glands was determined using the spherical model of OLINDA 1.1. PSMA-positive lesions were evaluated separately. …”
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    Biodistribution and radiation dosimetry of [(18)F]-JK-PSMA-7 as a novel prostate-specific membrane antigen-specific ligand for PET/CT imaging of prostate cancer
  15. 275
    “…Regions of interest were defined to derive individual and mean organ residence times; effective dose was calculated using OLINDA 1.1. RESULTS: All subjects tolerated (18)F-FPIA with no adverse events. …”
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    Clinical translation of (18)F-fluoropivalate – a PET tracer for imaging short-chain fatty acid metabolism: safety, biodistribution, and dosimetry in fed and fasted healthy volunteers
  16. 276
    “…Radiation dosimetry was estimated from the integrated TACs using OLINDA software. Safety assessments included measuring vital signs immediately before and after the scan, monitoring for adverse events, and obtaining a comprehensive metabolic panel and electrocardiogram within 30 days before and after the scan. …”
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    Human biodistribution and radiation dosimetry of the demyelination tracer [(18)F]3F4AP
  17. 277
    “…Absorbed and effective dose coefficients for each patient were assessed with OLINDA/EXM for the provided newborn and 1-year-old model. …”
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    Biokinetics, dosimetry, and radiation risk in infants after (99m)Tc-MAG3 scans
  18. 278
    “…Dosimetry calculations were performed with OLINDA software. ProBOMB1 and the nonradioactive Ga-ProBOMB were obtained in 1.1 and 67% yield, respectively. …”
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    Positron Emission Tomography Imaging of the Gastrin-Releasing Peptide Receptor with a Novel Bombesin Analogue
  19. 279
    “…Dosimetry was calculated based on biodistribution data using the mouse and human phantoms included in OLINDA. Acute toxicity was assessed in Sprague-Dawley rats at the dose of 0.742 mg/kg [(19)F]AmBF(3)-TATE, with a 14-day observation/recovery period. …”
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    Pharmacokinetics, radiation dosimetry, acute toxicity and automated synthesis of [(18)F]AmBF(3)-TATE
  20. 280
    “…Moreover, the internal radiation dosimetry was calculated using the OLINDA/EXM software. Safety was assessed based on feedback regarding adverse reactions and safety-related issues within 1 month after (64)Cu-NOTA-Trastuzumab administration. …”
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    A preliminary clinical trial to evaluate (64)Cu-NOTA-Trastuzumab as a positron emission tomography imaging agent in patients with breast cancer
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