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20521por Chen, Tong, Tian, Linlin, Chen, Jianglong, Zhao, Xiuhao, Zhou, Jing, Guo, Ting, Sheng, Qingfeng, Zhu, Linlin, Liu, Jiangbin, Lv, Zhibao“…The intersection of target genes of respective hub miRNAs and corresponding DE-mRNAs contributed to 250 downregulated candidate genes and 202 upregulated candidate genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses demonstrated the upregulated candidate genes mainly enriched in the terms and pathways relating to the cell cycle. …”
Publicado 2021
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20522por Tu, Yi, Wu, Quanli, He, Jiarui, Xu, Jiasheng, Yu, Shasha, Wang, Qingfei, Cheng, Yunqi, Yang, Qijun, Xu, Shan, Cao, Yi“…Protein–protein interaction analysis and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed on target genes. …”
Publicado 2021
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20523“…Then, an integrated analysis of these genes was performed, including gene ontology (GO) and KEGG pathway enrichment analysis in DAVID database, protein–protein interaction (PPI) network construction evaluated by the online database STRING, Transcription Factors (TFs) forecasting based on the Cytoscape plugin iRegulon, and their expression in varied organs in The Human Protein Atlas. …”
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20524por Zhou, Xueliang, Dou, Mengmeng, Liu, Zaoqu, Jiao, Dechao, Li, Zhaonan, Chen, Jianjian, Li, Jing, Yao, Yuan, Li, Lifeng, Li, Yahua, Han, Xinwei“…DE mRNAs were used to perform Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. …”
Publicado 2021
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20525“…Gene set enrichment analysis of DEGs was conducted to reveal the Gene Ontology (GO) biological process in each period. Dynamic molecular networks were constructed by DyNet to illustrate the common and distinct progression of health- or obesity-derived NAFLD. …”
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20526“…RESULTS: A total of 2491 DEGs with the false discovery rate less than 0.05(> 1.5-fold, P < 0.05 change) were identified, including 443 upregulated genes and 2048 downregulated genes. The Gene Ontology enrichment analysis showed that 26 out of the 2491 DEGs identified were associated with cardiovascular diseases. …”
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20527“…According to the differentially expressed (DE) miRNAs, putative target genes were predicted. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes enrichment analysis and DEmiRNA interaction network analysis were performed. …”
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20528“…Protein–protein interaction (PPI) network, gene ontology, and Kyoto Encyclopedia of Genes and Genomes enrichment analysis were performed to predict the function of the DEmRNAs. …”
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20529por Chen, Cheng, Guo, Qiang, Tang, Yang, Qu, Wendong, Zuo, Jiebin, Ke, Xixian, Song, Yongxiang“…The biological functions and signaling mechanisms of the differential immune genes were explored via Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis. …”
Publicado 2021
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20530por Dong, Yankai, Tao, Bo, Xue, Xing, Feng, Caixia, Ren, Yating, Ma, Hengyu, Zhang, Junli, Si, Yufang, Zhang, Sisi, Liu, Si, Li, Hui, Zhou, Jiahao, Li, Ge, Wang, Zhifei, Xie, Juanping, Zhu, Zhongliang“…The key targets of Epicedium for treating depression were IL6, VEGFA, AKT1, and EGF. According to gene ontology functional enrichment analysis, 22 items of biological process (BP), 13 items of cell composition (CC) and 9 items of molecular function (MF) were obtained. …”
Publicado 2021
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20531por Chang, Liang, Yao, Hao, Yao, Zhi, Ho, Kevin Ki-Wai, Ong, Michael Tim-Yun, Dai, Bingyang, Tong, Wenxue, Xu, Jiankun, Qin, Ling“…Venn diagram analyses were performed to identify the overlapping DEGs (overlapping DEGs) that expressed in at least two types of tissues mentioned above. Gene Ontology (GO) enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, protein-protein interaction (PPI) analysis, and module analysis were conducted. …”
Publicado 2021
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20532por Wang, Yanping, Wang, Jiying, Hu, Hongmei, Wang, Huaizhong, Wang, Cheng, Lin, Haichao, Zhao, Xueyan“…DEGs in cluster I displayed a pattern of decreasing to a nadir, and then a rise, and the significantly enriched gene ontology (GO) terms detected using them were involved in multiple processes, of which the cell cycle, immunocyte activation and proliferation, as well as actin cytoskeleton organization, were the top three overrepresented processes based on the GO terms functional classification. …”
Publicado 2021
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20533por Zou, Miao, Su, Xiaoyun, Wang, Luoying, Yi, Xingcheng, Qiu, Yue, Yin, Xirui, Zhou, Xuan, Niu, Xinhui, Wang, Liuli, Su, Manman“…First, gene expression profiles were downloaded from the gene expression omnibus database (GSE161200), and a TO-GCN was constructed using the breadth-first search (BFS) algorithm to infer the pattern of changes in the different organs over time. Second, Gene Ontology enrichment analysis was used to analyze the main biological processes related to COVID-19. …”
Publicado 2021
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20534“…Differentially expressed lncRNA (DElncRNAs) and DEmRNAs were identified from CAD and normal samples, and weighted gene co-expression network analysis (WGCNA) was conducted. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to investigate the principal functions of significantly dysregulated genes. …”
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20535por Zhao, Si-Jia, Jia, Hong, Xu, Xiu-Lian, Bu, Wen-Bo, Zhang, Qian, Chen, Xi, Ji, Juan, Sun, Jian-Fang“…Next, the key pathways were obtained by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. …”
Publicado 2021
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20536“…The bioinformatics analysis of these identified protein targets of polyphemusin-I in gene ontology (GO) enrichment category of molecular function revealed significant enrichment in nucleic acid related GO terms i.e., “RNA binding”, “nucleotide binding”, “nuclease activities”, “uracil DNA N-glycosylase activities” and others. …”
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20537“…METHODS: 13 genes related m[superscript 6]A from all the gene expressions in The Cancer Genome Atlas (TCGA) were screened. Gene Ontology (GO) and KEGG analysis were applied to explore the functions of genes identified in study. …”
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20538“…Further, we used the online Search Tool for the Retrieval of Interacting Genes/Proteins website, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes to conduct enrichment analysis and identify the predictive signaling pathways. …”
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20539“…For targeted mRNA functional analysis, gene ontology (GO) analyses and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were subsequently conducted. qRT-PCR validation and luciferase reporter assays were performed. …”
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20540por Yuan, Lingyun, Zheng, Yushan, Nie, Libing, Zhang, Liting, Wu, Ying, Zhu, Shidong, Hou, Jinfeng, Shan, Guo Lei, Liu, Tong Kun, Chen, Guohu, Tang, Xiaoyan, Wang, Chenggang“…The Kyoto Encyclopedia of Genes and Genomes and Gene Ontology annotations indicated the importance of the photosynthesis and photosynthetic-antenna protein pathways. …”
Publicado 2021
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