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21361“…When applied to a quantitative proteomics analysis of different molecular subtypes of breast cancer, PIGNON detects Gene Ontology terms that are both significantly clustered in a protein–protein interaction network and differentially expressed across different breast cancer subtypes. …”
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21362“…DAVID database was used for gene ontology (GO) and Kyoto encyclopedia of genes and genomes enrichment analysis. …”
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21363“…Next, co-expression analysis-based functional annotation revealed their association with gene ontology (GO) terms for ‘response to stress’, ‘response to biotic stimulus’, ‘immune system process’, etc. …”
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21364por Xiong, Qiuhong, Song, Ning, Li, Ping, Fischer, Sarah, Konertz, Roman, Wagle, Prerana, Glöckner, Gernot, Wu, Changxin, Eichinger, Ludwig“…Comparison of RNA(seq) and proteomic data further revealed, that only a small proportion of the transcriptional changes were reflected on the protein level. Gene ontology (GO) analysis revealed an enrichment of DEPs involved in lipid metabolism and oxidative phosphorylation. …”
Publicado 2021
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21365por Wang, Yan, Zhang, Yunwu, Wang, Yujia, Shu, Xinyao, Lu, Chaorui, Shao, Shiliang, Liu, Xingting, Yang, Cheng, Luo, Jingsong, Du, Quanyu“…R software was used to analyze the Gene Ontology biological processes (BPs) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. …”
Publicado 2021
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21366“…A total of 906 differentially expressed (DE) lncRNAs and 2,139 DE mRNAs were found in the CMV group. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to determine the biological functions or pathways of these DE mRNAs. …”
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21367“…Transcriptome profiling with further gene ontology certified biological processes investigated in vitro and indicated groups of genes consisting of AP-2 targets and molecules worth investigation as biomarkers. …”
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21368por Zhang, Leisheng, Chi, Ying, Wei, Yimeng, Zhang, Wenxia, Wang, Fuxu, Zhang, Lei, Zou, Linglin, Song, Baoquan, Zhao, Xing, Han, Zhongchao“…Subsequently, we systematically compared the potential similarities and discrepancy both at the cellular and molecular levels via flow cytometry, multilineage differentiation, chromosome karyotyping, cytokine quantification, and transcriptome sequencing and bioinformatic analysis including single-nucleotide polymorphism (SNP), gene ontology (GO), HeatMap, principal component analysis (PCA), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis (GSEA). …”
Publicado 2021
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21369“…Subsequently, differentially expressed genes (DEGs) analysis, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway functional enrichment analyses were performed, and protein–protein interaction (PPI) networks created for each phase. …”
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21370por Shadabi, Shahrzad, Delrish, Nargess, Norouzi, Mehdi, Ehteshami, Maryam, Habibian-Sezavar, Fariba, Pourrezaei, Samira, Madihi, Mobina, Ostadali, Mohammadreza, Akhgar, Foruhar, Shayeghpour, Ali, Razavi Pashabayg, Cobra, Aghajanian, Sepehr, Mozhgani, Sayed-Hamidreza, Jazayeri, Seyed-Mohammad“…The target gene hubs were subjected to further analysis to demonstrate significantly enriched gene ontology terms and signaling pathways. Quantitative reverse transcription Polymerase Chain Reaction (RTqPCR) was performed on major genes in certain pathways identified by network analysis to highlight gene expression alterations. …”
Publicado 2021
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21371por Xu, Qianhui, Xu, Hao, Deng, Rongshan, Wang, Zijie, Li, Nanjun, Qi, Zhixuan, Zhao, Jiaxin, Huang, Wen“…Differential analysis was performed between different level of TMB subgroups employing R package “limma”. Gene ontology (GO) enrichment analysis was implemented with “clusterProfiler”, “enrichplot” and “ggplot2” packages. …”
Publicado 2021
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21372“…GSE29718 and GSE9624 were sorted and 68 common differentially expressed genes (DEG) with fold change 1.5 upregulation or downregulation (cutoff |logFC|≥0.58496) were obtained. Gene ontology and functional enrichment and protein-protein interaction (PPI) network for the DEG were analyzed in Search Tool for the Retrieval of Interacting Genes (STRING), which revealed 37 biological processes, 3 cellular components, and 1 molecular function to be significantly associated. …”
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21373por Huang, Jialyu, Song, Ning, Xia, Leizhen, Tian, Lifeng, Tan, Jun, Chen, Qianqian, Zhu, Jing, Wu, Qiongfang“…Functional enrichment analyses of gene modules were conducted using Gene Ontology classification and Kyoto Encyclopedia of Genes and Genomes pathway. …”
Publicado 2021
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21374por Ma, Weijie, Yao, Ye, Xu, Gang, Wu, Xiaoling, Li, Jinghua, Wang, Ganggang, Chen, Xi, Wang, Kunlei, Chen, Yirang, Guo, Yonghua, Li, Yongsheng, Tan, Deli, Guo, Hui, Liu, Zhisu, Yuan, Yufeng, Claret, Francois X.“…Functional enrichment analysis by Gene Ontology (GO) showed that these seven prognostic lncRNAs exhibit oncogenic properties and are associated with prominent hallmarks of cancer. …”
Publicado 2021
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21375por Tong, Yuyang, Sun, Peixuan, Yong, Juanjuan, Zhang, Hongbo, Huang, Yunxia, Guo, Yi, Yu, Jinhua, Zhou, Shichong, Wang, Yulong, Wang, Yu, Ji, Qinghai, Wang, Yuanyuan, Chang, Cai“…Genes in modules related to metastasis were extracted for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, and a protein-protein interaction (PPI) network was built to identify the hub genes in the modules. …”
Publicado 2021
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21376por Quan, Jing, Bai, Yuchen, Yang, Yunbei, Han, Er Lei, Bai, Hong, Zhang, Qi, Zhang, Dahong“…The potential functions of identified DEGs were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). …”
Publicado 2021
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21377“…We used the R software screen the differentially expressed genes (DEGs). Gene ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway were analyzed by using the DAVID online tool. …”
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21378“…We further conducted protein-protein interaction analysis, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, gene set enrichment analysis, and gene-gene interaction analysis to explore the function and regulation networks of ERCC6 and ERCC8 in GC. …”
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21379“…Kyoto Encyclopedia of Genes and Genomes, Gene Ontology and Gene Set Enrichment Analyses were performed to explore differential cellular processes and signaling pathways between the two groups based on risk signature. …”
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21380por Chang, Zih-Ting, Huang, Yu-Feng, Chen, Yue-Wen, Yen, Ming-Ren, Hsu, Po-Ya, Chen, Tzu-Han, Li, Yi-Hsuan, Chiu, Kuo-Ping, Nai, Yu-Shin“…Of these DEGs, 168 genes were downregulated, and 87 genes were upregulated. Gene Ontology (GO) analysis showed that 141 DEGs (55.3%) were categorized into molecular functions, cellular components and biological processes. …”
Publicado 2021
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