“…RKB extends a number of ontologies and contains basic terminology for nucleic acid composition along with context/model-specific structural features such as sugar conformations, base pairings and base stackings. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Gramene began with the addition of an Ensembl genome browser and has expanded in the last decade to become a robust resource for plant genomics hosting a wide array of data sets including quantitative trait loci (QTL), metabolic pathways, genetic diversity, genes, proteins, germplasm, literature, ontologies and a fully-structured markers and sequences database integrated with genome browsers and maps from various published studies (genetic, physical, bin, etc.). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: The identification of three gene signatures showing a relevant overlap of pathways and ontologies, increases the likelihood of finding potential marker genes for AD.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It was found that current ontological, model and data repository resources and integrative software tools are sufficient to create composite models from separate existing models and the example composite model developed here exhibits emergent behavior not predicted by the separate models.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Specifically, including hyponym-hypernym relations yields a new semantic dimension of the map labeled here “abstractness” (or ontological generality) that is not reducible to any dimensions represented by antonym pairs or to traditional affective space dimensions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We describe the coding schema and key system features as well as several development challenges, including data integration, development of a final data structure from three separate ontologies, and ways to develop consensus about codes among program staff.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Contrary to expectation, these molecular changes do not point to metabolic pathways but instead reside in broadly developmental ontologies. We propose that, rather than being adaptive, these changes may simply produce an inappropriate response to suboptimal environments; maladaptive phenotypes may be avoidable if postnatal nutrition is carefully controlled.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Pathway enrichment and ontological analysis were incorporated into the refined network to highlight the main molecular scheme of cerebellar wound healing. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, robust curating of bioassay data, establishment of ontologies enabling mining of large chemical biology datasets, and a wealth of public chemical biology information has made possible the establishment of highly annotated compound collections. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Phenotypes associated with engineered and natural genetic variation are widely recorded using phenotype ontologies in model organisms, as are signs and symptoms of human Mendelian diseases in databases such as OMIM and Orphanet. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Genes that were highly expressed in young iris significantly enriched electron transport chain, transcription, metabolism, and cell cycle gene ontologies, all of which are associated with lens regeneration. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this article, we review these challenges, and the ongoing efforts to address them, which are emerging from bioinformatics work on ontologies, evolutionary statistics, and data curation, with a focus on their implementation in the context of the development of our database Bgee (http://bgee.org). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We show that the schizophrenia loci are strongly linked to synaptic transmission (P (FWE) < .001) and ion transmembrane transport (P (FWE) = .03), but not to ontological categories previously found to be shared across psychiatric illnesses. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Unprincipled modeling decisions in large-domain ontologies, such as SNOMED CT, are problematic and might act as a barrier for their quality assurance and successful use in electronic health records. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Little is currently known about dynamic brain networks involved in high-level cognition and their ontological basis. Here we develop a novel Variational Bayesian Hidden Markov Model (VB-HMM) to investigate dynamic temporal properties of interactions between salience (SN), default mode (DMN), and central executive (CEN) networks—three brain systems that play a critical role in human cognition. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is unclear whether this lack of T cells is a consequence of an ontological defect, causing the thymus to generate and export T cells incapable of surviving in the periphery, or whether (alternatively or additionally) mature T cells intrinsically require GIMAP1 for survival. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Scientists explain uncertainty in autism research through discussion of epistemological uncertainties which suggest that diverse methods and techniques make results hard to reconcile, ontological uncertainties which suggest doubt over taxonomic coherence, but also through reference to autism’s indeterminacy which suggests that the condition is inherently heterogeneous. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We propose BioSearch — a semantic search engine that uses ontologies to enhance federated query construction and organize search results. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Fifty-seven articles comprising a topic assortment of algorithms, biomolecular networks, cancer and disease informatics, drug-target interactions and drug efficacy, gene regulation and expression, imaging, immunoinformatics, metagenomics, next generation sequencing for genomics and transcriptomics, ontologies, post-translational modification, and structural bioinformatics are the subject of this editorial for the InCoB2017 supplement issues in BMC Genomics, BMC Bioinformatics, BMC Systems Biology and BMC Medical Genomics. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To understand how infection by Mycobacterium tuberculosis (Mtb) is modulated by host cell phenotype, we characterized those host phagocytes that controlled or supported bacterial growth during early infection, focusing on the ontologically distinct alveolar macrophage (AM) and interstitial macrophage (IM) lineages. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso