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23821Biomarkers in patients with heart failure and central sleep apnoea: findings from the SERVE‐HF trialpor Ferreira, João Pedro, Duarte, Kévin, Woehrle, Holger, Cowie, Martin R., Wegscheider, Karl, Angermann, Christiane, d'Ortho, Marie‐Pia, Erdmann, Erland, Levy, Patrick, Simonds, Anita K., Somers, Virend K., Teschler, Helmut, Rossignol, Patrick, Koenig, Wolfgang, Zannad, Faiez“…METHODS AND RESULTS: Circulating protein‐biomarkers (n = 276) ontologically involved in CV pathways, were studied in 749 (57% of the trial population) patients (biomarker substudy), to investigate their association with the study outcomes (primary outcome, CV death and all‐cause death). …”
Publicado 2020
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23822por Zayed, Hatem“…Methods: The GSE43696 omnibus gene expression dataset, which contains 50 moderate cases, 38 severe cases, and 20 healthy controls, was used to investigate differentially expressed genes (DEGs), susceptible chromosomal loci, gene networks, pathways, gene ontologies, and protein–protein interactions (PPIs) using an intensive bioinformatics pipeline. …”
Publicado 2020
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23823“…Functional enrichment analysis of the affected genes revealed several enriched gene ontologies and KEGG pathways related to fat metabolism. …”
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23824por Voisin, Sarah, Harvey, Nicholas R., Haupt, Larisa M., Griffiths, Lyn R., Ashton, Kevin J., Coffey, Vernon G., Doering, Thomas M., Thompson, Jamie‐Lee M., Benedict, Christian, Cedernaes, Jonathan, Lindholm, Malene E., Craig, Jeffrey M., Rowlands, David S., Sharples, Adam P., Horvath, Steve, Eynon, Nir“…However, gene set enrichment analysis did not reveal any enrichment for gene ontologies. CONCLUSIONS: We have developed a muscle‐specific epigenetic clock that predicts age with better accuracy than the pan‐tissue clock. …”
Publicado 2020
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23825“…Enrichment analysis of top trans-eQTLs revealed high enrichment for gene categories and gene ontologies associated with genomic context and expression regulation. …”
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23826por Papadaki, Vasiliki, Asada, Ken, Watson, Julie K., Tamura, Toshiya, Leung, Alex, Hopkins, Jack, Dellett, Margaret, Sasai, Noriaki, Davaapil, Hongorzul, Nik-Zainal, Serena, Longbottom, Rebecca, Nakakido, Makoto, Torii, Ryo, Veerakumarasivam, Abhi, Kaneko, Syuzo, Sagoo, Mandeep S., Murphy, Gillian, Mitani, Akihisa, Tsumoto, Kohei, Kelly, John D., Hamamoto, Ryuji, Ohnuma, Shin-ichi“…On the other hand, we found that in the bladder epithelia, the knockout mice of OMD and/or PRELP gene caused partial EMT and a loss of tight junctions of the umbrella cells and resulted in formation of a bladder carcinoma in situ-like structure by spontaneous breakdowns of the umbrella cell layer. Furthermore, the ontological analysis of the expression profiling of an OMD knockout mouse bladder demonstrated very high similarity with those obtained from human bladder cancers. …”
Publicado 2020
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23827por Taylor, Laura W., French, John E., Robbins, Zachary G., Nylander-French, Leena A.“…We explored the functions of the genes that have been published in the literature and used GeneMANIA to investigate gene ontologies and predicted protein-interaction networks. …”
Publicado 2021
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23828por Pushparaj, Peter Natesan, Abdulkareem, Angham Abdulrahman, Naseer, Muhammad Imran“…Here, we used the raw RNA-seq reads (Single-End) in quadruplicates derived using Illumina Next Seq 500 from SARS-CoV-infected primary human bronchial epithelium (NHBE) and mock-treated NHBE cells obtained from the Gene Expression Omnibus (GEO) (GSE147507), and the quality control (QC) was evaluated using the CLC Genomics Workbench 20.0 (Qiagen, United States) before the RNA-seq analysis using BioJupies web tool and iPathwayGuide for gene ontologies (GO), pathways, upstream regulator genes, small molecules, and natural products. …”
Publicado 2021
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23829“…Four datasets (GSE42568, GSE45827, GSE54002 and GSE76124) were analyzed by bioinformatic methods and the differential expression genes (DEGs) between the AR positive TNBC tissues and normal tissues were firstly identified by limma package and Venn diagrams. Next, Gene Ontologies (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to explore the relationship between these DEGs. …”
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23830“…This is particularly in light of the hyper-real, otherworldly, and often ontologically challenging yet potentially transformative, nature of the experience, not least encounters with apparently non-self social agents. …”
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23831“…Genetic mapping with the phenotypic data we collected revealed three QTL across two chromosomes, two associated with TR(lim) traits and one associated with leaf temperature. Analysis of Gene Ontologies of genes within QTL regions identified several intriguing candidate genes, including one gene that when overexpressed had previously been shown to confer enhanced tolerance to abiotic stress. …”
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23832por Paape, Timothy, Heiniger, Benjamin, Santo Domingo, Miguel, Clear, Michael R., Lucas, M. Mercedes, Pueyo, José J.“…When plant genotypes with the most extreme phenotypes were compared, we found significant divergence in genomic regions using population genomics methods that contained metal transport and stress response gene ontologies. Several of these genomic regions show high linkage disequilibrium (LD) among candidate genes suggesting they have evolved together. …”
Publicado 2022
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23833por Frennert, Susanne, Erlingsdóttir, Gudbjörg, Muhic, Mirella, Rydenfält, Christofer, Milos Nymberg, Veronica, Ekman, Björn“…The analysis also revealed a theme of materiality that deviated from the NPT constructs, as NPT gives ontological priority to human actors and social structures. …”
Publicado 2022
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23834por Wang, Yuli, Fang, Yuan, Zhao, Fanchen, Gu, Jiefei, Lv, Xiang, Xu, Rongzhong, Zhang, Bo, Fang, Zhihong, Li, Yan“…Finally, we estimated enrichment of gene ontologies categories and relevant signaling pathways using GO annotations, KEGG, and GSEA pathway data. …”
Publicado 2022
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23835por Griesinger, Andrea, Riemondy, Kent, Eswaran, Nithyashri, Donson, Andrew, Willard, Nicholas, Paine, Simon, Bowes, Georgia, Rheaume, John, Chapman, Rebecca, Ramage, Judith, Jackson, Andrew, Grundy, Richard, Foreman, Nicholas, Ritzmann, Timothy“…A subpopulation of cells with wound healing ontologies and characterized by TREM1 expression, demonstrated features of myeloid derived suppressor cells, including IL6/STAT3 pathway activation. …”
Publicado 2022
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23836por Adams, Joselyn M, Valentine, Christina J, Karns, Rebekah A, Rogers, Lynette K, Murase, Masahiko, Fowler, Grace N, Nommsen-Rivers, Laurie A“…Transcripts were assessed for differential expression (false discovery rate adjusted P value <0.05) and clustering between EXP compared with STD groups. Ontological analysis of all differentially expressed genes (DEGs) was performed with Toppcluster. …”
Publicado 2022
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23837por Zhang, Zhongrong, Quan, Shaowen, Niu, Jianxin, Guo, Caihua, Kang, Chao, Liu, Jinming, Yuan, Xing“…The 88 JrbZIP genes were involved in DNA binding and nucleus and RNA biosynthetic processes of three ontological categories, molecular functions, cellular components and biological processes. …”
Publicado 2022
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23838por Chen, Yuanying, Sun, Qiqing, Hao, Chanjuan, Guo, Ruolan, Wang, Chentong, Yang, Weili, Zhang, Yaodong, Wang, Fangjie, Li, Wei, Guo, Jun“…DCM is a genetically heritable disease and more than 10 gene ontologies have been implicated in DCM. CDH2 encodes N-cadherin and belongs to a superfamily of transmembrane proteins that mediate cell–cell adhesion in a calcium-dependent manner. …”
Publicado 2022
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23839“…Patients were selected using HERON (Healthcare Enterprise Repository Ontological Narration) software. We compared age at diagnosis, type and size of the tumor, radioactive iodine (RAI) use, and DTC recurrence amongst patients with GD with non-GD patients. …”
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23840por Matthews, Michael R.“…This paper will document the book’s two fundamental errors: namely, its Kantian-influenced ontological idealism and its claims of incommensurability between competing paradigms. …”
Publicado 2022
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